Biomedical subjects
B Mancini
Publications and source records attributed to B Mancini.
Immunopathology of the Lens. III. The effect of experimental allergic uveitis on the cation balance in the lens.
Rabbit lenses from eyes suffering from experimental allergic uveitis showed a clear enhancement in the 86Rb efflux as compared to the lenses from the fellow normal eyes. Intracellular K+ was also significantly decreased and Na+ significantly increased after several relapses of inflammation.
Immunopathology of the lens. II. 86Rb efflux and protein leakage from normal lenses exposed to antilens and antiuveoretina antibodies.
Normal rabbit lenses exposed in vitro to heterologous antilens and antiuveoretina antibodies lose control of the intracellular 86Rb and this effect is followed by a late leakage of lenticular proteins; both phenomena take place only in the presence of complement. This antibody-induced complement-dependent membrane damage might be involved in the pathogenesis of complicated cataracts in uveitis and in the self-maintenance of recurrent uveal inflammations.
Immunopathology of the lens. I 86Rb efflux and protein leakage from normal lenses exposed to unrelated antigen-antibody interactions.
Normal rabbit lenses exposed in vitro to heterologous antibody (Ab)--antigen (Ag) interactions lose control of the intracellular 86Rb; this membrane damage, which seems to be related to the quantitative ratio Ab/Ag, is relatively complement independent and is followed by a subsequent leakage of lenticular proteins. A possible implication of these findings in the development of complicated cataracts in uveitis (as 'permeability cataracts') and in the self-maintenance of recurrent uveal inflammation is shortly discussed.
Release of protein and cations from the lens in the presence of different antigen-antibody interactions.
Rabbit lenses exposed to unrelated Ag/Ab interactions and to heterologous anti-lens and anti-uveo-retinal antibodies show alterations of their permeability with loss of Rb+ followed by efflux of macromolecular intracellular constituents; these phenomena take place also without complement when the ratio of the unrelated Ag/ab is in Ag excess, while complement is strictly required for the action of anti-tissue antibodies. The possible role of these findings as regards the pathogenesis of complicated cataracts in uveitis and the self-maintenance of recurrent uveitis is briefly discussed.