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Biomedical subjects

B Mathias

Publications and source records attributed to B Mathias.

8 recordsLinked to original sources
PubMed1993

Immune thrombocytopenia associated with hemorrhagic diathesis due to ibuprofen administration.

Acute thrombocytopenic purpura temporally related to the oral administration of ibuprofen developed in a patient with ankylosing spondylitis. Clinical manifestations, with sudden onset occurring within 12 h of drug ingestion and rapid increase of platelet counts following discontinuation of the drug, were characteristic of an antibody-mediated immune pathomechanism. Immunological studies demonstrated IgM and IgG antibodies in the patient's serum that were capable of binding to allogenic platelets in the presence of a metabolite preparation. This finding suggested that an ibuprofen metabolite, rather then the drug itself, was the antigenic agent responsible for the immune reaction. Despite its widespread therapeutic use, ibuprofen has not been described previously as causing immune-mediated thrombocytopenia.

Aged↗
PubMed1989

[Oral contraceptives: undesirable effects in internal medicine].

Eight instructive clinical case reports on younger women demonstrate the actual problem of severe adverse reactions (ADR) associated with oral contraceptives. Complications consisted of cerebral arterial thrombosis, peripheral arterial thrombosis, cerebral embolism, pelvic vein thrombosis, pulmonary embolism, thrombosis of the sinus sagittalis, recurrent pancreatitis and focal nodular hyperplasia of the liver. Contraindications of hormonal contraception (i.e. heavy smoking) were not always taken seriously by the prescribing physician. The data bank of the Medicines Commission of the German Medical Association contributed 648 cases to draw an ADR frequency profile, according to age, doses, duration of prescription and deaths. 25 deaths in close connection to oral contraception intake were reported, mostly caused by arterial or venous thromboembolism. Deaths predominantly were reported in women less than or equal to 30 years old, mostly following exposition to low-dose-preparations and after relatively short duration of intake (less than or equal to 3 years). These non-representative observations call for strict consideration of contraindications and use of low-dose-preparations, even in younger women.

Adult↗
PubMed1988

[Adverse effects of antihistaminics].

Of most antihistamines more or less pronounced sedative effects are known. In recently developed substances this effect is said to be less or absent. After some days of application the sedative effect may decrease, but it can be enhanced by simultaneous intake of psychotropic drugs, sedatives or alcohol. There are important interindividual differences. The Drug Commission of the German Medical Profession (AKdA) received reports concerning tiredness, somnolence (even with new antihistamines), CNS-stimulation, nervousness, insomnia and paroniria have also been observed. Furthermore cases of dyskinesia have been reported, which are already described in the literature after long term intake, as well as anticholinergic reactions. Despite of their use as antiallergic drugs, reports on hypersensitivity reactions due to antihistamines, up to anaphylactic reaction have been not infrequently received by the AKdA. In rare cases disturbances of blood cell formation have been reported besides observations of gastrointestinal disorders, increase of appetite and weight. Abuse of antihistamine containing drugs was reported mainly for combinations with psychotropic agents.

Histamine Antagonists↗
PubMed1986

[Thiobarbituric acid positive substances as indicators of lipid peroxidation].

Polyenic acids of particularly membrane-bound lipids can be disintegrated non-enzymatically by oxygen radicals or enzymatically by peroxidation. Final products of the lipid peroxidation are malon dialdehyde, n-alcanes, n-alcanales, hydroxyalcanales, 2-alcenales. Alca-2,4-dienales. Hydroxyalcenales and ketones. Products of lipid peroxidation can react with proteins and glycosaminoglycans. Thus receptor binding of the LDL, enzyme activities, DNA- and protein synthesis can be inhibited. Of the peroxidation products malon dialdehyde is relatively specifically recognizable by the reaction of the thiobarbituric acid. Size and clinical significance of processes of lipid peroxidation are up to now only little known in several diseases, but they might be of great importance for numerous pathological processes.

Chemical Phenomena↗