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Biomedical subjects

B Mehić

Publications and source records attributed to B Mehić.

12 recordsLinked to original sources
PubMed2001

[Frequency of tobacco smoking in groups of patients with pulmonary diseases].

UNLABELLED: The importance of active smoking on respiratory health has been demonstrated in both cross-sectional and longitudinal studies. There is a time lag of cca 20 yrs between initiation of smoking and the appearance of disease symptoms. PROBLEM: Data about tobacco smoking and duration of smoking are very important in patients with lung diseases. AIMS: To evaluate the frequency of smokers and duration in some groups of patients with lung diseases. Also to determinate Statistically Significant Difference (P < 0.01) in average duration of smoking and average number of cigarettes per day between the observed groups. PATIENTS AND METHODS: We analyzed a randomized clinical sample from 6 groups of patients according to lung diseases. In every group we analyzed percentage of smokers, age, the frequency of male and female smokers, average duration of smoking and average number of cigarettes per day. RESULTS: Some of the results shown in tables and graphs. CONCLUSIONS: The highest percentage of smokers was at the group of patients with Lung cancer, the longest average duration of smoking was in the group of smokers with COPD, the highest average number of smoked cigarettes was in the group of smokers with pulmonary embolism etc.

Adult↗
PubMed2001

[Nicotine addiction].

According to the WHO reports from 1997, Bosnia and Herzegovina takes a disgraceful first place in smoking prevalence in Europe. 53% of smokers over 15, then 22% of women, 67% of men are percentages that are not achieved by countries at a much lower development level than B&H. The mortality rate of men (aged 35-64) as a result of tobacco varies from 11% to 45% from country to country. In 11 European countries it is > or = 40% and they are all in the eastern part of the region: Belarus, the Czech Republic, Hungary, Kazakhstan, Lithuania, Poland, Russia, Slovenia, Ukraine, B&H. Tobacco addiction, like other drug addictions, is basically a neurobiological mediated brain disease. In the same way, the discontinuation of drug taking, in this case nicotine, is a very important addiction component and one of its clearest manifestations. So, the symptoms of iving up smoking are in fact the symptoms mediated by noradrenalien (excitement, tension, long-lasting desire, distraction, insomnia, increase in appetite, putting on weight, etc). According to the Diagnostic and Statistical Manual for Mental Disorders-4th Edition (DSM-IV), both toxicomanic nicotine addiction and the discontinuation of smoking are classified as diseases. The smokers who give up smoking before they are 50 decrease their mortality risk by 50% over the next 15 years compared to those who continue smoking. This risk decrease is related to the incidence decrease and mortality rate from specific, smoking-related diseases, including: coronary heart disease, strokes, peripheral vascular diseases, COPD and lung cancer. The assistance to addict to give up of smoking is duty of professionals.

Adult↗
PubMed2000

[Sarcoidosis activity in a comparison of the tuberculin test and the endoscopic picture in a randomized clinical sample].

The study population consisted of 100 patients with sarcoidosis, selected by method of accidental selection. According to clinical form of sarcoidosis, the sample was divided, in three groups: group of patients with chronic form of sarcoidosis (SHFS)--36 patients, group of patients with acute form of sarcoidosis (SAFS)--46 patients, and group of patients with asymptomatic form of sarcoidosis (SAsFS)--18 patients. The aim of study was to determine whether there were statistically significant differences between the groups of different sarcoidosis clinical forms in diagnosis time in connection with tuberculin reaction, endoscopic picture and index of sarcoidosis activity? Which level of correlation was between index of sarcoidosis activity and tuberculin reaction, respectively endoscopic picture on observed groups of sarcoidosis patients? On the basis of our results we reached the following conclusions: there was significant correlation between magnitude of tuberculin reaction and index of sarcoidosis activity in SAsFS, in SAFS correlation there was no significance and in SHFS there was no correlation. In all of three groups the most frequent was endoscopic picture of enlarged and irregularly arranged capillaries with yellowish plaques on bronchial mucous with average index of activity (6.7).

Adult↗
PubMed1999

[Approach to the evaluation and management of pleural effusions].

A pleural effusions arise as a complication of many different diseases basically they could be divided to: nonmalignant, malignant, and paramalignant effusions. This article is actually a review of etiological moments, pathogenesis, clinical presentation, the characteristics of pleural fluid, diagnosis, prognosis and treatment of pleural effusions. The aim of the article was to point to the clear principals which should be respected in situations of making the diagnosis, evaluation of prognosis and making plans for the treatment of pleural effusions, particular in cases of malignant pleural effusions.

Humans↗
PubMed1999

[An addition to the clinical algorithm for treatment of patients with community-acquired pneumonia in Bosnia-Herzegovina: a multicenter prospective study in Sarajevo].

UNLABELLED: The Patient Pneumonia Outcomes Research Team (PORT) has developed a scoring system that allows the severity of illness to be quantitatively measured. Using an algorithm, the patient can be classified as to risk. The total number of points assigned to the patient increases risk of poor outcome. Patients in risk classes I, II and III have an expected mortality (< 5%) and should be managed as outpatients. Patients with risk class IV and V have mortality rates of 8-29% and should be admitted to the hospital. Patients with risk class V will usually require intensive care. AIM: We started a multicenter prospective study in Sarajevo, to investigate some differences in demographic factors, comorbid diseases, physical examination findings, laboratory findings, the duration, complications and mortality in our population with CAP, than in recommended algorithm. MATERIAL AND METHODS: We recorded the cases of 163 patients (100 male, 63 female) with mean age 58.6 years (17-91). The sample was statistical elaborated with tests of distribution frequency and hi square test. RESULTS: Between demographic factors, as significant, beside age, there was nicotine abuse in 53% (for our CAP population). In comorbid diseases as significant disease beside preexisting cancer (10.5%), chronic liver disease (4%), renal disease (13%), congestive hearth failure (27%), cerebrovascular disease (5%), there was COPD (31%) and diabetes mellitus (9%). Some differences were in physical examination findings, and laboratory findings. The duration of illness, complications and mortality in our CAP population was like in other studies. CONCLUSIONS: This work speaks us that our CAP population has some differences in observed characteristics of scoring system. But, without regard to all this, patients with following characteristics should also be admitted to an intensive-care unit and would be classified as patients with severe pneumonia: hypotensia (systolic blood pressure < 90 mm Hg), impending respiratory failure that may require mechanical ventilation, hypoxaemia (pO2 < 60 mm Hg), hemodynamic instability, heart failure, diabetes mellitus (tip I), COPD, poor dental hygiene (anaerobes--necrotizing pneumonia, empyema, abscess).

Adolescent↗
PubMed1997

[Truths and misconceptions about human diseases, medicine and therapy].

The relationship between the truth an misconceptions, which was applied in diagnosis an therapy has been discussed in this work. Concept of the truth and misconceptions has been discussed through the relationship doctor-patient, and the question whether tell the truth about serious, incurable patient's in context of Hippocrates Code and the rules of the religion of Islam.

Humans↗
PubMed1995

[Smoking as a risk factor in the onset of bronchial carcinoma].

With regard to proved fact that smoking plays very important role in appearance of the lung cancer, prevention of the lung cancer goes together with fight against smoking. Since smoking is narcotism, prevention of smoking is the only solution of the problem of smoking, respectively that is the only prevention of bronche-cancer. For those who continue smoking, there is some suggestions, such as: not to smoke the last third of cigarette, do not inhale smoke deeply, to reduce number of consumed cigarette, and to have regularly examinations, i.e. to have X-ray examination of the lung on the six months basis.

Carcinoma, Bronchogenic↗
PubMed1995

[Evaluation of polychemotherapy of small cell lung carcinoma].

Small cell carcinoma of the lung is a separate clinical and pathological entity with characteristics of early and wide dissemination, and also great sensitivity on chemotherapy and radiotherapy. We evaluated results of therapy of patients with pathohistological verification of small cell carcinoma of the lung with use two polychemotherapy regimes (VCAV and CAP) particular or in combination with radiotherapy. We achieved the best results with application VCAV regime alone (local response 100%, complete response 78.6%, partial response 21.4%) or, in combination with radiotherapy in relation on CAP regime. Our results, when compared to experiences of foreign authors, though we evaluated it on minority series, also demonstrated better results when both regimes of polychemotherapy were used.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1993

[Analysis of the results of bronchoalveolar lavage (BALF) in patients with pulmonary sarcoidosis].

Bronchoalveolar lavage is a relatively new method in pulmonology. Treatment of broncho-alveolar fluid-washing/BALF/obtained after the procedure of broncho-alveolar lavage/BAL/enables obtaining of samples for investigation of inflammatory and immune cells, so-called alveolar, which, treated by different laboratory procedures, represent the source for different informations at many lung diseases. Analysis of BALF is significant in the differential diagnosis of interstitial lung changes, in the estimate of process activity as well in analysis of therapy with glucocorticosteroids, as well as in the estimate of immune cells state, particularly T abd B lymphocyte subpopulations. We have analysed BALF in 161 patients with lung sarcoidosis with the purpose of analysing the process activity and according to activity of lymphocyte alveolitis in relation to total lymphocyte number in BALF cytogram and by identification of T and B lymphocytes and their subpopulations/CD4, CD8, CD11/as well as by the index CD4/CD8. We have determined the CD4, CD8, CD11 values as well as B lymphocytes by monoclonal antibodies, manufactured by ORTHO-mune/USA/, signed by the manufacturer as OKT4, OKT8, OKT11, OKT22, conjugated by gost antimice IgG antibodies. The working procedure we have done according to instructions of the manufacturer by immunofluorescent technic.

Adolescent↗
PubMed1993

[Characteristics of the pneumonia syndrome in adults during the war in Sarajevo 1992-1993].

We have compared some vital statistics and symptoms as well as clinical findings of the patients hospitalised due to primary non specific lung inflammation in the previous period of aggression at Bosnia and Herzegovina with those in patients hospitalised before the aggression at Bosnia and Herzegovina. The frequency of hospitalisation due to bronchopneumoniae and pleuropneumoniae has been more frequent during the war about three times, while the frequency of treatment from pneumoniae has been the same as before the war. The war population of hospitalised is distinguished in aged persons and persons suffering from chronic diseases, in particular alcoholism, chronic hepatitis and so on. Generally observing, symptoms and physical signs has been more significantly expressed in the war than in the pre-war hospitalised population. The remarkable fact is that clinical findings of values drop of alpha 1 globulins is expressed as well as erythrocytes and the slow increase of leucocytes value in the war in relation to pre-war population of hospitalised from the non specific lung inflammation. The significantly prolonged is the treatment duration, the time of roentgenologic regression of the findings as well as the period of normalisation of haematologic findings with more frequent finding of acute complications (abscess, empyema) in the war than in the pre-war population.

Adult↗
PubMedDate not supplied

[Evidence of the harmful effects of eosinophils in bronchial asthma].

Fifteen asthmatic patients were prospectively selected. If they had more than 450 eosinophils in peripheral blood on admission to hospital treatment and if before BAL had been performed they were not treated by corticosteroids. No associated disease was found which could cause the increased number of eosinophils in peripheral blood except bronchial asthma. BAL was performed when the subjects tested had no dyspnea, usually 1-3 days after the hospital admission. In contrast to blood eosinophilia, increase of eosinophils number in BAL was found to correlate to impairment of clinically measured parameters such as: ventilation level of blood gases and duration of hospitalisation. On the contrary there was no correlation between the level of blood eosinophilia and gas disturbance and duration of hospitalisation. Eosinophilic proteins (MBP, ECP, EPX, EPO) are not the only that harmfully effect the lung cells in the asthmatic attack but the fact that their level in lavage fluid correlates to eosinophilia degree in BAL is evident so the correlation between the number of eosinophils in BAL and impairment of clinically measured parameters is clear.

Asthma↗