Biomedical subjects

B Mende

Publications and source records attributed to B Mende.

7 recordsLinked to original sources

PubMed2000

Sonographic markers of exencephaly at 9 + 3 weeks of gestation.

Following the introduction of transvaginal sonography, several first trimester diagnoses of the exencephaly anencephaly sequence have been reported, with the earliest being described at 10 weeks of gestation. We report a case with a high index of suspicion for exencephaly at 9 weeks and 3 days because of three sonographic features: the cranial pole of the embryo was smaller than the chest, the cranial pole bulged dorsally and the surface of the cranium was irregular. The diagnosis was confirmed by a repeat ultrasound examination at 11 + 4 weeks and by autopsy after termination of pregnancy.

Adult↗

PubMed1991

[Bacteriologic findings before and in transcervical chorionic villi biopsy and their clinical relevance].

Between August 1987 and May 1989, bacteriological examinations of smears from the cervical canal was performed in 358 pregnant women, who underwent transcervical sampling of chorionic villi. The outcome of 349 of these pregnancies is documented. 12 of these patients (3.5%) had an artificial abortion for genetic reasons. In 12 other patients, the pregnancy ended before 28 weeks (one child surviving). Microbiological examinations showed that in 187 women (52%), it was possible to culture one or more microorganisms from the cervical canal. The most frequently detected pathogen was Chlamydia trachomatis (111 women, 31%). In pregnancies, where more than one microorganism could be cultured, the risk of following abortion was 8.9 times higher than in those, where no pathogens could be found. In only two of the 12 women with a subsequent spontaneous abortion (16.6%), no microorganism could be found. The bacterial contamination of the cervical canal during TC-CVS seems to be a risk factor for subsequent abortion. Therefore, a bacteriological examination of cervical flora should be performed before as well as during TC-CVS, and antibiotic therapy should be initiated in case of positive results.

Abortion, Septic↗

PubMed1987

[Treatment of keloids by cryotherapy].

Cryotherapy was performed on 7 patients with 35 keloids of different pathogenesis. In 5 out of these patients, prior treatment with creams, radiotherapy, or excision followed by radiotherapy had failed. The keloids were frozen several times by contact with liquid nitrogen (40 to 90 sec). After bullous local reactions and crusted healing, the lesions gradually leveled down. Atrophic scars resulted after 1 to 8 treatments. Old keloids (2 to 8-year-old) showed good therapeutic response. No relapses were registered during the follow-up period of 3 month up to a year. Only one patient discontinued therapy, and a 10-year-old boy could not stand the initial pain of freezing. On account of our encouraging results and the low complication rate, we recommend cryotherapy in the treatment of old keloids.

Cryosurgery↗

PubMed1987

[Hypotrichosis congenita hereditaria Marie Unna with Ehlers-Danlos syndrome and atopy].

A family suffering from hypotrichosis congenita hereditaria Marie Unna is reported (16 members affected in five generations). The typical symptoms of this autosomal dominant syndrome were found: pili torti, canaliculi et trianguli, inborn generalized hypotrichosis, later on resulting in alopecia of the androgenetic type. A 19-year-old female patient with hyperandrogenemia was treated with cyproterone acetate and ethinyl estradiol. Furthermore, hypotrichosis was associated with Ehlers-Danlos syndrome and atopic symptoms in the last three generations of the family. There does not seem to be any genetic connection between the syndromes however.

Adult↗

PubMed1985

[Failure to form wrinkles on the finger tips in the warm water test in lepromatous nerve damage].

In order to estimate the extent of nerval defects, we recommend the soaking test which may reveal affected areas indicated by the loss of wrinkling at the finger-tips after soaking the hands in warm water for half an hour. Thus we found impairment in the formation of wrinkles in 6 out of 7 tested patients suffering from different types of leprosy. In order to study the significance of the soaking test with regard to acute nerval signs and symptoms, one patient was reexaminated when he showed acute painful swelling of the right n. ulnaris. There was normal wrinkling observed at the affected hand, which did not differ from the outcome of the preceding test. This finding indicates that the soaking test is only appropriate to the examination of chronic nerval lesions in leprosy.

Adolescent↗

PubMed1985

[Bone changes in Hansen's disease].

Bone lesion is a frequent organic manifestation in leprosy. Osseal destructions caused by granulomatous process induced by M. leprae are so-called specific lesions in contrast to non-specific lesions based on nerval or arterial diseases. The specific osseal alterations are characterized by cystic brightenings in roentgenograms while non-specific osseal changes show absorption to bone structure as akroosterolysis and osteoporosis. Typical radiologic findings in different stages of mutilation are demonstrated.

Bone Diseases↗

PubMed1985

[Osteitis leprosa multiplex cystica--an early symptom of lepromatous leprosy].

Bone lesions of the finger in a 20-year-old leprosy patient are described to show their diagnostic value. The aetiological differences between specific (caused by Mycobacterium leprae itself) and unspecific osseal changes are morphologically noticeable in morbus Hansen. The X-ray picture shows cystic lightening by granulomatous destruction and distal absorption of the bone. These lesions are typical, and radiological investigations might be the first step in the diagnosis of leprosy. In our case, ostitis leprosa multiplex cystica, an early, specific bone lesion, was predominant.

Adult↗