Biomedical subjects
Publications and source records attributed to B Mendelson.
A follow-up study of 12 patients who had preformed silicone implants inserted for correction of body contour deformities (8 for pectus excavatum and 4 for soft-tissue deformities of the shoulder and pectoral region) has demonstrated the safety of this technique and its lack of significant early or late complications. No implants have been removed, and 10 of the 12 patients regarded the overall results as good or excellent.
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Exposure to ethanol is known to alter the development of the serotonergic system. However, previous studies have examined large populations of cells and have not determined the effects of ethanol on individual serotonergic neurons. In the present study, the effects of various concentrations of ethanol on the development of single serotonergic neurons in the chick embryo spinal cord were determined using immunohistochemical techniques. Between embryonic day 7 (E7) and E14, ethanol administrations produced in ovo alcohol concentrations of: a) low dose, 30-60 mg/dl, b) medium dose, 150-200 mg/dl or c) high dose, 240-300 mg/dl. In animals exposed to the medium and high ethanol doses, the normal developmental increase in cross-sectional area of the somata was not observed. At all stages examined, the numbers of primary and nonprimary processes were significantly lower in ethanol-treated groups compared to controls. These data indicate that ethanol exposure induces dose-dependent alterations in the development of identified spinal cord neurons. The ethanol-induced changes may be involved in the motor dysfunction observed after embryonic ethanol exposure.