PubMed Health⌕ Search

Biomedical subjects

B Mesarić

Publications and source records attributed to B Mesarić.

6 recordsLinked to original sources

[Cytomegalovirus retinitis in patients with human immunodeficiency virus infection].

Cytomegalovirus retinitis (CMVR) is a common opportunistic infection and a major cause of blindness in patients with AIDS. The aim of this study was to determine the frequency, clinical course and outcome of CMVR in patients treated at the University Hospital of Infectious Diseases "Dr. Fran Mihaljević" in Zagreb in the period from January 1995 to April 1996. CMVR was diagnosed in 8 (27.5%) of 29 patients with AIDS. The median CD4 lymphocyte count in patients with CMVR was 44 per mm3, six patients had less than 50 per mm3. Five patients died during the study period, the mean survival being 5.5 months. CMVR was present in both eyes in 5 (62.5%) patients at the time of diagnosis. Blindness in both eyes developed in 3 (37.5%) patients. In order to recognize and promptly treat CMVR frequent ophthalmologic examinations should be performed in patients with advanced HIV disease.

AIDS-Related Opportunistic Infections↗

A contribution to the knowledge about autoimmune eye diseases.

In this paper the autoimmune eye disease complex is presented in detail. The problems of autoagressivity in the light of new conceptions based on modern microchemical, chemical and immunological methods of analysis that allow better insight in the nature of these diseases are discussed. The basic concepts of immunological mechanisms and autoimmunity are explained, with special attention given to those occurring in the eye. Attention is directed towards the importance of various intra- and extraocular factors, as well as to the regulatory mechanisms that influence the autoimmune eye disease's development. In the conclusion the authors analyze the abilities and aims of further investigations of this field of ophthalmoimmunopathology.

Autoimmune Diseases↗