Biomedical subjects

B Mirtl

Publications and source records attributed to B Mirtl.

4 recordsLinked to original sources

PubMed1982

[Comprehensive review of the possibilities and limits of drug therapy of rheumatic diseases].

Practically 10-20% of all patients registered with a General Practitioner complains of symptoms in some way associated with rheumatism. Incidences of this disorder are distributed in such a way as to form a pattern whereby 55% is troubled with extra-articulary rheumatism, 38% with arthrosis and spondylarthrosis and 7% with rheumatoid arthritis. It is of most importance that the General Practitioner identifies these patients during the early stages of their disorder, and that he commerces the necessary treatment immediately. With the exception of streptococcus-rheumatism and gout, the pathogenesis of rheumatics eludes us to this day. As far as individual measures are concerned therefore, it is merely a question of selecting some kind of treatment, ranging from the symptomatic to the semi-causal, which can be used alongside the recommended form of therapy. The author describes various kinds of treatment including NSTAR, Glucocorticoids, Antisuppressives and basic therapy such as Chloroquin, gold and D-Penicillamin.

Adrenal Cortex Hormones↗

PubMed1975

[The value of pyrophosphate scintigraphy for the assessment of the activity of spondylarthritis ankylopoietica (author's transl)].

Seriological and scintigraphic activity was compared in 29 patients with spondylarthritis ankylopoietica (Bechterew's disease). Among our cases, 11 serologically active patients also had positive scans. the details being: cervical vertebral column in 5, thoracic vertebral column in 7 cases and the lumbar vertebral column and iliosacral joint in all 11 patients. In the group of 16 serologically inactive patients, 12 cases could be confirmed radiologically, in the remaining 4 early detection of ankylosing spondylarthritis was possible from the scintigraphic findings in combination with the clinical symptoms. The clinically suspected diagnosis of an incipient Bechterew's disease could not be justified in the remaining 2 patients who had no positive scintigraphic or serological results.

Adolescent↗

PubMedDate not supplied

[Joint scintigraphy using 99mTc pyrophosphate].

Joint scintigraphy was performed in 85 patients suffering from a variety of rheumatic diseases, using a gamma camera and line scanner. Tc-pyrophosphate was the radio nuclide employed; it accumulates selectively in the juxta-articular parts of the bone. The method provides an objective demonstration of inflammatory and degenerative rheumatic joint changes. More over scintigraphic changes can be demonstrated in joint disease which is too early to be clinically apparant or before there are any corresponding changes in serological parameters. The method is useful both in the localisation and staging of disease, in the evaluation of treatment and as an objective control of clinical skills.

Arthritis, Infectious↗

PubMedDate not supplied

[Clinical effectiveness and tolerance of auranofin in patients with chronic polyarthritis. Results of a multicenter long-term study].

In an open multicenter trial, 90 patients with rheumatoid arthritis were treated with a daily dose of 6 mg auranofin. The duration of the treatment was 12 months. A significant improvement in the following parameters was observed: grip strength, number of swollen and painful joints after the 4th month, blood erythrocyte sedimentation rate decreased significantly after the 2nd month. Of the 90 patients, 56 (62.3%) completed the therapy, in 14 (15.5%) it was discontinued because of side effects and in 8 (8.9%) because of inefficacy. 12 patients (13.3%) stated other reasons for discontinuing the therapy (non compliance). The reported side-effects were mostly gastrointestinal, especially diarrhoea and loose stools. The evaluation of results referring to the duration of the disease shows that patients with a duration of less than 2 years reacted better to the improvement with auranofin therapy than patients with a longer sickness history.

Adult↗