Biomedical subjects

B Mladenov

Publications and source records attributed to B Mladenov.

6 recordsLinked to original sources

PubMed1997

[The correlation between serum thyroglobulin and iodine-131 scanning in detecting metastases in patients with a differentiated thyroid carcinoma].

One-hundred seventy-one patients, operated for differentiated thyroid gland carcinoma, are subjected to serum thyroglobulin assessment and whole-body scanning. In twenty-nine of the total of 171 patients there is evidence of relapses and metastases, discovered by either examination. In 27/29 cases with metastases (positive scan finding) a high serum thyroglobulin level is documented. The correlation between serum thyroglobulin level and whole-body scanning finding among patients without residual normal thyroid parenchyma (status post total thyroidectomy) is much more favourable than the one in patients presenting normal residual parenchyma (status post organ-salvaging operation). The conclusion is drawn that serum thyroglobulin contributes greatly to the diagnosis of recurrences and metastases, especially in patients with normal residual parenchyma missing.

Adenocarcinoma, Follicular↗

PubMed1995

[The routine immunohistochemical diagnosis and surgical treatment of medullary carcinoma of the thyroid].

Over the period 1977 through 1988, in the Research Institute of Surgery--Medical Academy a total of 372 patients undergo primary operative management for thyroid gland carcinoma. Medullary carcinoma is discovered in 18 patients of the series (4.8 per cent). The preoperative diagnosis is supplemented by thyroscintigraphy with 131iodine or technetium Tc 201. After 1981, calcitonin and carcinoembryonic antigen (CEA), specific medullary thyroid carcinoma (MTC) markers, measurements are routinely done, with substantially elevated levels in the patients under study being found, in those with metastases inclusive. Presumably, the preoperative diagnosis medullary thyroid carcinoma is very difficult, and only a combined approach, including thyroidectomy with ensuing iodine radiotherapy, may account for a good survivorship. Postoperatively, all patients with MTC diagnosis are regularly tested for serum calcitonin and CEA levels. The carefully taken family history and questioning of the patients allows to differentiate familial from cases from sporadic neoplasms.

Adult↗

PubMed1989

[Dynamic gamma-camera scintigraphy as a method for evaluating the function of the ovarian parenchyma].

A dynamic gamma-camera scintigraphy is proposed as a combined method, providing morphological and functional picture for the presence of eventual pathological changes in the region of ovaries. After detailed description of the method results from the examination of 45 women are presented: 35 suffered from diseases, involving adnexal region and 10--are controls. It is established that normal ovaries are visualized medially from the large iliac vessels as clear, ovally formed homogeneous cumulation of radionuclide. No such cumulation is observed after lack of ovarian parenchyma or after not well made perfusion. The method has serious advantages, when anomalies in the development of ovaries are search for as well as in diseases, changing form and size of the ovary (deformation, lack of homogeneity, ect.). A method is proposed for its advantage that it is not invasive, the examination is performed easily and is safe for patients.

Adolescent↗

PubMed1989

[Dynamic gamma-camera excretory scintigraphy in the diagnosis of a rare anomaly in the development of the internal genitalia (the Slotnik-Goldfarb syndrome with uterus unicornis)].

The combination of a missing ovary and uterine tube on the one side (the syndrome of Slotnik-Goldfarb) with ipsilateral absence of the uterine horn is a rare anomaly, undescribed in our obstetric-gynecological literature. The difficulties in the diagnosis of this anomaly are connected with the necessity to use invasive methods for establishment of respective changes. The method was used in a woman, suffering from sterility, in connection with examining the possibilities of dynamic gamma-camera scintigraphy to discover ovarian parenchyma. Hysterosalpingography proved the presence of a hypoplastic uterine horn on the right side, an uterine tube on the same side (changed and nonpatent). Dysovulatory syndrome was established in this woman clinically. The performed scintigraphy confirmed the presence of ovarian parenchyma on the right side as well as a hypoplastic uterine horn and uterine tube and complete lack of accumulation of radionuclide on the left side, which suggested absence of ovarian parenchyma in the sideé in which the uterine horn and uterine tube were undeveloped as well. It is evaluated that the scintigraphic technique, described by the authors, could be used for establishment of such rare anomalies by noninvasive way.

Adult↗

PubMed1988

[Second neoplasms in malignant hemopathies].

12 cases of a second malignant neoplasm in patients with a systemic hematologic disease were for a 10-year-period among the patients of a hematologic clinic. Seven of these cases are reported in detail. The factors which lead to this phenomenon becoming more frequent are discussed.

Adult↗

PubMed1984

[Blast stage in chronic myeloleukemia--diagnostic and therapeutic problems].

The data are reported from the study on 34 patients with chronic myeloleukosis (ChML), blast stage (BS). The early progress of BS is stressed upon--in 41% of the patients during the first year after making the diagnosis. A juxtaposition is made between some clinical and laboratory indices and the BS progress as well as with life span. Some criteria are presented that could aid the differentiation of BS from a recurrence of ChML. The unsatisfactory results from BS treatment are also stressed upon in spite of the achievements during the last several years. One of the patients was with twice overcome BS, with a duration of the second remission of 8 months.

Adult↗