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Biomedical subjects

B Mokri

Publications and source records attributed to B Mokri.

At least 73 records · Page 4Linked to original sources
PubMed1985

Surgical treatment of idiopathic hydrocephalus in elderly patients.

We studied 45 adult patients with idiopathic hydrocephalus who had undergone a shunting procedure at the Mayo Clinic during a 16-year period. The follow-up period extended up to 157 months. Thirty-four of the 45 patients (75%) improved at some time after the operation, and 19 (42%) experienced continuous improvement. The median duration of improvement was 24 months. Patients who had symptoms for less than 2 years were most likely to improve. CT played an important role in the diagnosis and follow-up, but ventricular size or degree of atrophy did not correlate with response.

Aged↗
PubMed1984

Intracranial schwannoma of the hypoglossal nerve.

Two patients had a solitary intracranial schwannoma of the hypoglossal nerve. Such schwannomas are rare, and these two cases bring the total number of reported cases to 16. Hemiatrophy of the tongue is always present but is rarely reported by patients. Diagnosis can be facilitated by high-resolution computed tomographic scanning of the posterior fossa and foramen magnum region. The hazards formerly associated with removal of these tumors have largely been eliminated.

Adult↗
PubMed1984

Meniere's disease: a 30-year epidemiologic and clinical study in Rochester, Mn, 1951-1980.

One hundred eighty cases of Meniere's disease were identified in the Rochester, MN population during the 30-year period, 1951 through 1980. The annual age-adjusted incidence rate per 100,000 population was 15.3; the preponderance for females (16.3) over males (13.3) was not statistically significant. There was no change in annual incidence rate from 1951 through 1970, and a slight decrease in the period, 1971 through 1980. The prevalence rate on January 1, 1980, was 218.2 per 100,000 population. Clinical aspects of Meniere's disease noted during the course of this study are reported.

Adolescent↗
PubMed1982

Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment.

Of 40 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 28 completed a controlled three-month trial of prednisone. Prednisone was shown to cause a small but significant improvement over no treatment in scored neurological disability, some measures of computer-assisted sensory detection threshold, graded muscle strength, and some attributes of nerve conduction. No subset of patients was more likely than another to be responsive to prednisone; those with a progressive course were as likely to be responsive as recurrent cases. This finding provides further justification for classifying progressive with recurrent cases as CIDP and demonstrates that prednisone treatment should not be withheld from patients with progressive disease.

Adolescent↗
PubMed1982

Extracranial internal carotid artery aneurysms.

Extracranial internal carotid artery aneurysms are uncommon. The symptoms of these aneurysms vary according to their location and size. Larger aneurysms may present as cervical or parapharyngeal masses, which may or may not be pulsatile or tender; there may be an associated systolic bruit. Pharyngeal hemorrhage, epistaxis, or bleeding from the ear are rare manifestations. Ischemic symptoms are a frequent mode of presentation of these aneurysms. Arterial diseases, particularly atherosclerosis, may predispose the vessel to the formation of the aneurysm. Sometimes trauma is the cause. We report herein six cases of extracranial internal carotid artery aneurysms. The modes of presentation, the etiologic factors, the pathologic observations, and the methods of management are discussed, and the pertinent literature is reviewed.

Adult↗
PubMed1981

Disulfiram neuropathy.

In four patients, sensorimotor polyneuropathy developed during treatment with disulfiram. Each patient began to improve with the cessation of treatment. Clinical, electrophysiologic, and pathologic observations point to a potentially reversible and probably dose-related axonal polyneuropathy.

Adult↗
PubMed1980

Unusual causes of unilateral serous otitis media.

Two cases of nonkeratinizing squamous cell carcinoma (transitional cell carcinoma), both of which arose in the Eustachian tube, and two cases of neurilemoma of the nasopharynx are reported. All four patients presented with unilateral serous otitis media. The duration of the unilateral serous otitis media in these patients ranged from 1 1/2 to 8 years. This emphasizes the fact that adult patients with unilateral serous otitis media without a history of an upper respiratory tract infection or of barotrauma should undergo thorough examination to rule out the presence of an unusual underlying pathologic condition.

Carcinoma, Squamous Cell↗
PubMed1979

Spontaneous internal carotid dissection, hemicrania, and Horner's syndrome.

We describe five patients with angiographic features of dissecting aneurysm of the cervical portion of the internal carotid artery who were seen initially with unilateral headaches and ipsilateral oculosympathetic paresis. This combination of symptoms is a rather common mode of manifestation of this entity.

Adult↗
PubMed1977

Idiopathic regressing arteriopathy.

Three patients had nonatheromatous occlusive cervicocephalic arterial disease which on follow-up showed resolution of the occlusive or stenosing abnormalities. The patients' relatively young age (middle thirties to middle forties) and severe unilateral headache or focal head, neck, or mastoid pain were prominent common clinical features. The dominant arteriographic features were intimal irregularities, multiple vessel involvement, tendency to arterial dissection and aneurysm formation, sparing of intracranial arteries, and tendency to partial or complete resolution of the abnormalities and regression toward normal. We have called this presumed entity "idiopathic regressing arteriopathy" pending appropriate histopathological studies.

Adult↗
PubMed1975

Duchenne dystrophy: electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of the muscle fiber.

In seven patients with Duchenne dystrophy, high-resolution phase microscopy demonstrated a population on non-necrotic fibers with one or more focal lesions. The typical lesion was wedge-shaped, with the base resting on the fiber surface. In the electron microscope, the plasma membrane overlying the lesion was either absent or disrupted, while the basement membrane was always preserved. Within the lesion, there were cytoplasmic abnormalities, and in the neighboring fiber region, the myofibrils were usually highly contracted. The structural defect in the plasma membrane suggested that this site was an ineffective cellular barrier. This was confirmed by the frequent ingress of peroxidase-containing extracellular fluid into the lesions. In two control subjects, peroxidase penetration into fibers was seen only rarely and only with other evidence of mechanical injury to the specimen. The findings point to an early and possibly basic abnormality in the plasma membrane of the muscle fiber in Duchenne's dystrophy.

Adult↗
PubMedDate not supplied

MR findings in normal-pressure hydrocephalus: significance and comparison with other forms of dementia.

This study was undertaken to identify findings on magnetic resonance (MR) imaging that might possibly differentiate among several dementia states in the elderly or predict response to shunt therapy in patients with normal-pressure hydrocephalus (NPH). The MR findings were retrospectively reviewed in 54 patients who were divided into four clinical categories: NPH (17 patients), obstructive hydrocephalus (eight patients), Alzheimer disease (eight patients), and non-Alzheimer dementia (21 patients). Three MR findings were evaluated in each case: increased periventricular (PVS) and white matter (WMS) signal on T2-weighted images, CSF flow void sign (CFVS) in the aqueduct, and corpus callosum thinning. Neither the PVS/WMS nor corpus callosum thinning patterns were useful for distinguishing among the four clinical groups. At low field strength, the absence of a marked or moderate CFVS, however, may militate against a diagnosis of NPH. All 17 patients with NPH underwent a shunt procedure after the MR study. A better response to shunt therapy occurred in patients without WMS and with more severe PVS.

Adult↗
PubMedDate not supplied

Internal carotid artery dissection after childbirth.

A 44-year-old woman developed a left cerebral infarction secondary to internal carotid artery dissection 6 days after childbirth. A cesarean section had been carried out after 14 hours of strenuous unsuccessful labor. Although in the past some authors have implicated oral contraceptives as a cause for carotid dissection, carotid dissection associated with childbirth has not been previously described.

Adult↗
PubMedDate not supplied

Spontaneous dissections of the renal arteries in a patient with previous spontaneous dissections of the internal carotid arteries.

An otherwise healthy 35-year-old woman suffered spontaneous dissections of both internal carotid arteries. She made an excellent recovery but was left with occlusion of the left internal carotid artery and a residual subcranial dissecting aneurysm of the right artery--both were asymptomatic. Eight years later, spontaneous dissections of both renal arteries occurred. The exact nature of the underlying arterial disease is not clear. Although fibromuscular dysplasia is suspected, other undetermined arteriopathy cannot be excluded.

Adult↗