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B Morra

Publications and source records attributed to B Morra.

At least 37 records · Page 2Linked to original sources
PubMed1983

Specific LIF production in laryngeal cancer patients: evidence of suppressor activity exerted by adherent cells.

The specific tumor-induced LIF production in 30 laryngeal cancer patients has been investigated before and after the removal of adherent cells to evaluate the existence of a suppressor activity. LIF production, after challenging lymphocytes with 3 M KCI autologous tumor extracts, was significant in 16 patients and showed a further significant increase after removal of adherent cells. A conversion to significance when the adherent cells were removed was shown in 6 patients, with no previous significant LIF production. These data suggest the existence of a suppressor activity exerted by adherent cells on LIF production in laryngeal cancer patients.

Antigens, Neoplasm↗
PubMed1983

Influence of pre-voicing duration on dichotic performance.

When two speech messages are presented to normal subjects in a dichotic listening task, the stimuli presented to the right ear are generally reported first and more accurately than signals presented to the left ear. Although a normal Italian speaker produces approximately 100 ms of pre-voicing, we found that the maximum dichotic interference (shown by a slightly larger right-ear advantage and fewer double-correct trials) occurred for stimuli with 30-ms pre-voicing. These data indicate that the duration of pre-voicing is important for intelligibility of Italian stop consonants.

Adult↗
PubMed1983

Dichotic performance of Italian subjects tested with english and Italian stop consonant-vowel stimuli.

15 normal-hearing, right-handed Italian subjects were tested dichotically with Italian and English stop consonant plus vowel combinations (CVs). The stimuli were modified on a computer-based routine so that the pre-voicing of Italian voiced CVs was 30 ms long. In this condition, a significant right-ear advantage and a consistent lag effect were observed with both Italian and English stimuli. In addition, no significant differences between the two types of stimuli (English and Italian) were observed in the dichotic performances (except when using the 90-ms lag, which resulted in a significant difference in performance).

Adult↗
PubMed1982

Production of leukocyte migration inhibition factor by lymphocytes of larynx cancer patients stimulated by laryngeal carcinoma solubilized membrane antigens.

The production of leukocyte migration inhibition factor (LIF) from lymphocytes after stimulation with 3 M KCl soluble tumor and normal mucosa extracts was investigated in 30 patients with laryngeal carcinoma at different development stages and in 30 normal donors. The experiments were performed in heterologous and autologous systems. In heterologous systems 3 M KCl tumor extracts induced LIF production by heterologous lymphocytes from patients in 91% of the cases, and normal mucosa extracts induced LIF production by heterologous lymphocytes from patients in 73% of the cases and from normal donors in 90% of the cases. In autologous systems 3 M KCl tumor extracts induced LIF production by autologous lymphocytes from the same patients in 65% of the cases, whereas the normal laryngeal mucosa extracts induced LIF production by the same autologous lymphocytes in the 6% of the cases. The high positivity percentage of the test in heterologous systems could be related to differences in the major histocompatibility complex. The 65% test positivity in autologous systems using tumor extracts could be related to the presence of tumor associated antigens.

Antigens, Neoplasm↗
PubMed1981

Vestibular nerve compression in eighth-nerve tumors.

The superior vestibular nerve was studied histologically in 25 patients who underwent removal of inferior vestibular nerve schwannoma. In most cases, the nerve fibers were structurally normal but the endoneurial space showed various degrees of capillary stasis and/or extravasation of red blood cells. Increased fibrosis of the endoneurial space was seen in about two-thirds of the cases; it was mild in all except two cases. The endoneurial space appeared edematic in about one-third of the cases. Wallerian degeneration of individual fibers was occasionally observed in most cases and was severe in the two cases with moderate or severe endoneurial fibrosis. In about one-third of the cases there were large numbers of myelinated nerve fibers with thinned myelin sheaths. The observed structural changes are compatible with those seen in human and experimentally induced chronic compressive or entrapment neuropathies. Thus, early symptoms of eighth-nerve tumors might develop due to direct compression of the eighth-nerve trunk within the internal auditory canal.

Cranial Nerve Neoplasms↗
PubMed1980

Relationships between cervical node histological patterns and rosette test scores: possible prognostic value in laryngeal cancer.

In previous research the authors have remarked that some hystological patterns--macrophagic hyperplasia and thymus-dependent areas hyperplasia--when prevailing in cervical nodes of laryngeal cancer patients, possess a positive prognostic value. In this study the possible relationship between the results of E and EAC-rosettes and prevailing hystologic patterns in cervical nodes is investigated. A positive correlation was not found. Conclusively, the inconsistency of aspecific tests for prognostic purposes and the need for a specific immunological monitoring system are outlined.

Humans↗
PubMedDate not supplied

Nasal secretory IgA circadian rhythm: a single-dose suppression test.

The existence of a clear circadian rhythm in the local secretion of nasal IgA is well-known phenomenon which is confirmed in the present research. Since the temporal pattern of secretory IgA (SIgA) strictly parallels the ACTH-cortisol cycle, a dependence was hypothesized in previous research, but the suppression of adrenal rhythm by means of massive doses of exogenous corticosteroids showed no influence on the SIgA cycle. In the present research a more sophisticated method of corticoid-incretion suppression was used; the single-dose suppression test with dexamethasone, which influences only the impulsive phase of the rhythm. In this case too, however, no influence was demonstrated on nasal SIgA secretion.

Circadian Rhythm↗
PubMedDate not supplied

Natural killer-mediated cytotoxicity in patients with laryngeal carcinoma.

Natural killer (NK)-mediated cytotoxicity against the K562 cell line was evaluated in normal subjects and in patients with laryngeal cancer. Results showed reduced lymphocyte cytotoxicity in patients with neoplastic disease and further reduction in NK activity following postoperative radiation therapy. The authors discuss the possibility of using this test in the immunological monitoring of patients with laryngeal carcinoma.

Cell Line↗
PubMedDate not supplied

Prospects and limitations of systematic monitoring in patients with laryngeal cancer.

The authors report the first results concerning the systematic use of "immunological monitoring" in patients suffering from well-developed laryngeal cancer. The authors have also studied, in 50 cases in different stages of development, the activity of T-cells using the cutaneous tests (BCG, PPD, PHA and SK-SD), the E-rosette test and the PHA-induced lymphocytic blastization test (it is well known that the T-cells are responsible for a cytotoxic effect against neoplastic cells). The authors have also studied the activity of B-lymphocytes by means of the EA and EAC rosette test and of IgG, IgA, IgM and complement serum titles. They have observed a progressive depression of the T-cell activity after surgical intervention, whereas the B-cell activity in several cases tends to increase. The authors discuss these immunological results and the possibility that these findings may represent the basis for a complementary immunotherapy following the surgical treatment and/or radiotherapy or chemotherapy. Finally, the authors discuss the possibilities and the limitations of these immunological methods from the point of view of clinical application.

B-Lymphocytes↗
PubMedDate not supplied

Air and bone conduction brain stem responses in adults and infants.

Air and bone conduction brain stem responses were recorded in 20 adults and 20 infants (16-20 months postconceptional age) with normal hearing. The stimuli were administered using a shielded TDH-39 headphone and a standard B-70A vibrator. Our results show that adults and infants have similar air and bone conduction brain stem thresholds. The comparison of input latency functions obtained with air and bone conduction clicks indicates that the acoustic stimulus generated by the bone vibrator excites more apical regions than that stimulated by the air conduction transient. This is related to the spectrum of the bone conduction click which has an energy peak at 1-2 kHz. Furthermore we found that the difference in latency between adults and infants for air-conducted clicks decreases along with the stimulus intensity and the latencies tend to overlap near the threshold.

Adult↗