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Biomedical subjects

B Mosimann

Publications and source records attributed to B Mosimann.

7 recordsLinked to original sources
PubMed1992

[Allergy to cockroaches in a Swiss population with asthma and chronic rhinitis].

Cockroach extracts are known to contain powerful allergens. In some parts of the world the majority of asthmatics have been shown to be allergic to cockroaches. We have evaluated the prevalence of sensitization to the cockroaches Blattella germanica and Trogoderma angustum in a Swiss population with chronic, non-seasonal asthma and rhinitis. The sera of 110 patients were screened for specific IgE by the RAST technique. We found 10 positive RAST (class 1 to 2). 7 of the 110 patients were sensitized to cockroaches (6.3%). 3 patients had positive RASTs for both species of cockroach. 2 patients had no other detectable allergy (= 5% of those who were considered as non-allergic before the study). These results suggest that allergy to cockroaches is uncommon in Switzerland but can sometimes be detected. We conclude that in Switzerland, screening for hypersensitivity to cockroaches should not be included in routine allergic investigations.

Adolescent↗
PubMed1991

Clinical evaluation of a new in-vitro assay for specific IgE, the immuno CAP system.

The Pharmacia CAP system is a new assay for specific IgE characterized by a new solid phase (hydrophilic polymer encased in a capsule). The CAP results were compared to those of the Phadebas IgE RAST and skin-prick tests (SPT) performed in 145 subjects suffering from rhinitis and/or asthma with eight common inhalant allergens (total number of tests = 1160). Concording CAP/RAST results were found in 91% of the tests. The CAP was positive in 78% and the RAST in 65% of the positive SPT. Conversely, the CAP was negative in 90.6% and the RAST in 96.4% of the negative SPT. A pattern negative SPT, negative RAST and positive CAP' was found in 56 tests (40 subjects): in four such subjects, the CAP positivity was confirmed by a positive IgE crossed radioimmunoelectrophoresis. Three borderline positive results were found among 240 negative controls (serum from cord blood or non-atopics). These data indicate that compared with SPT the CAP system is (a) more sensitive than the Pharmacia RAST and (b) does not seem less specific.

Adolescent↗
PubMed1987

Accelerated idioventricular rhythm during flexible fiberoptic bronchoscopy.

We report the case of a patient who developed severe hypoxemia and an unusual arrhythmia, accelerated idioventricular rhythm, during flexible fiberoptic bronchoscopy. Coronary artery disease was subsequently suspected despite an unremarkable history and physical examination, and confirmed by a thallium 201 imaging. The appearance of accelerated idioventricular rhythm during fiberoptic bronchoscopy should raise the possibility of underlying coronary artery disease.

Aged↗