Histological and clinical overlapping.
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Branchioma↗
Biomedical subjects
B Muezzinoglu
Publications and source records attributed to B Muezzinoglu.
Verumontanum mucosal gland hyperplasia is associated with atypical adenomatous hyperplasia of the prostate.
BACKGROUND: Verumontanum mucosal gland hyperplasia (VMGH) and atypical adenomatous hyperplasia (AAH) are both small glandular proliferations that are histologically and topographically unique. METHODS: One hundred ten randomly selected, whole-mount, radical prostatectomy specimens were reviewed to assess independently the normal histology of the prostatic urethra and periurethral area and the association of AAH with other pathologic features, including VMGH. The degree of nodular hyperplasia was evaluated by total prostate weight for comparison purposes. RESULTS: Atypical adenomatous hyperplasia was found in 37 cases (33.6%) and was nearly always (32/37) associated with nodules of nodular hyperplasia. Verumontanum mucosal gland hyperplasia was present in 32 cases (29.1%; 21 with AAH, 11 without AAH). There was a significant association between presence of VMGH and AAH (P <.001, Fisher exact test). The degree of nodular hyperplasia was not significantly different between prostates with and without VMGH or AAH. CONCLUSIONS: These results suggest that AAH and VMGH occur more commonly in prostates when the other is also present.
Aged↗
Stromal microcalcification in prostate.
Prostatic calcification is most commonly encountered as calculus or intraluminal calcifications within atypical small glandular proliferations. This study was undertaken to detect stromal microcalcifications in prostate tissue. All slides from 194 needle biopsies were retrospectively reviewed. Six cases (3.1%) had stromal microcalcifications constantly associated with mononuclear inflammatory infiltrate around the each focus. Association with prostatic glands was not seen in any of the microcalcification foci. Three cases had simultaneous adenocarcinoma and one had high-grade prostatic intraepithelial neoplasia, all of which were apart from the microcalcification foci. In conclusion, stromal microcalcification is a dystrophic, inflammation-mediated, benign process.
Adenocarcinoma↗
Fibrocartilaginous dysplasia: a variant of fibrous dysplasia.
Eight cases of fibrous dysplasia having enchondroma-like areas (fibrocartilaginous dysplasia) are reported. Four patients were male, four were female. The patients' ages ranged from 8 to 18 years (mean = 11.3 years). In seven cases, the lesions were located at the proximal femur while one was at the tibial diaphysis. Histologically, large, well-defined, sharply demarcated islands of hyaline cartilage tissue were seen within the typical fibro-osseous stroma of fibrous dysplasia. Some of the cartilage islands showed growth plate-like enchondral ossification at the periphery. Cartilage islands were mostly low in cellularity but infrequently, hypercellular areas were detected. Prolonged growth plate columns or developmental cartilage nests are considered in the origin of the cartilaginous component. In the differential diagnosis from benign and malignant chondroid tumours, the lack of atypia in the surrounding fibrous stroma is important.
Adolescent↗
Helicobacter pylori status and cell proliferation activity in chronic antral gastritis.
BACKGROUND: Helicobacter pylori is known to cause antral gastritis and multifocal atrophic gastritis. In addition to its inflammatory effect, H. pylori has a direct effect on gastric mucosa. Increased epithelial proliferation, which may be an early biologic change in the development of gastric carcinoma, can be measured using silver stain for nuclear organizer regions (AgNOR). AIM: To detect the relation between H. pylori colonization and AgNOR index. METHODS: One hundred and twenty consecutive antral endoscopic biopsy specimens from patients with dyspepsia were examined for H. pylori colonization, polymorphonuclear infiltrate, mononuclear infiltrate, germinal center formation, mucus depletion and AgNOR index. RESULTS: AgNOR indices were not significantly related to grades of H. pylori colonization and chronic and active inflammation. The index increased significantly (p=0.03; ANOVA) with increasing mucin depletion. CONCLUSION: H. pylori colonization and presence of gastric antral inflammation are not related to cell proliferation activity; the latter is associated with mucin depletion.
Adult↗