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B Mulligan

Publications and source records attributed to B Mulligan.

6 recordsLinked to original sources

Listening, priming and emotion under a neuroleptic drug.

The authors previously found that emotional arousal increased the asymmetry of facial and other lateralised expressive behaviours. Chlorpromazine equalized the symmetry of behaviour by reducing emotional arousal rather than by blocking all behaviour. These results raise the question of whether the perception of emotion is also lateralised and similarly influenced by chlorpromazine. Sixteen student volunteers were administered placebo and 50 mg of chlorpromazine in tablet form on separate occasions two hours before carrying out two tests of lateralised perception. Dichotic recognition of positive and neutral but not negative emotional words revealed a right ear advantage. No drug effect was observed. The speed of recognition of words and nonwords was also examined following emotionally toned priming words lateralised to the visual hemifields. This task showed some parallel findings to the dichotic test but some lateralised effect of the drug was observed.

Adult

Lateralization of emotional expression under a neuroleptic drug.

Sixteen student volunteers were administered placebo and 50 mg of chlorpromazine (CPZ) in tablet form, on separate occasions, two hours before testing. Whilst volunteers related pleasant and unpleasant personal life events, the frequency and intensity of expressions on the left and right sides of the face were rated by independent observers. Subsequently the valence of the narration was also rated. Similar to a previous study facial expressions during negative emotions were expressed more often and intensely in the left face but positive emotions were bilaterally represented. CPZ neutralised the emotion on both sides of the face, irrespective of whether it was positive or negative. However, because negative emotions were almost completely lateralised to the left face the drug's effect on this emotion was most pronounced on this side. Independent ratings of the narration of the life events showed CPZ made them more pleasant. It is suggested that emotional arousal increases the asymmetry of behaviours when these are unilaterally represented or controlled. CPZ may equalize the symmetry of behaviour by reducing emotional arousal rather than by blocking all behaviour.

Adolescent

A nurse specialist program in a small hospital.

An innovative program in a small hospital can greatly enhance quality of patient care and nurse satisfaction at nominal cost. A custom-designed nurse specialist program was developed successfully by the nursing department at a 49-bed hospital and can easily be adapted to other rural facilities with similar needs.

Colorado

Treatment of grade III and IV astrocytomas with BCNU alone and in combination with VM-26 following surgery and radiation therapy.

Twenty-one patients with grade III or IV astrocytomas were assigned randomly to receive either BCNU alone or BCNU and VM-26 after surgery and radiation therapy. Patients surviving radiation therapy and receiving single-agent chemotherapy had a median survival of 14 months while those receiving combination chemotherapy had a median survival of 22 months (P greater than 0.05). None of the patients who failed BCNU-only therapy responded to VM-26. Performance status was not affected by either regimen. Computerized tomographic scanning of the brain was useful only in confirming tumor progression. Two patients died from BCNU-related interstitial pulmonary fibrosis.

Adolescent