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Biomedical subjects

B N Gupta

Publications and source records attributed to B N Gupta.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

Ototoxicity of cis-dichlorodiammine platinum (II) in guinea pigs.

Effects of cis-dichlorodiammine platinum (II), an agent that has potent antineoplastic activity, were studied in guinea pigs. With repeated administration of a daily dose of 1.5 mg/kg of cis-dichlorodiammine platinum, the cochlear microphonics were suppressed. Suppression of the cochlear microphonics was greater in the basal turn than in the third turn of the cochlea. There was a close correlation between loss of the cochlear hair cells and suppression of the cochlear microphonics. The endocochlear potential was decreased in the basal turn but remained unchanged in the upper turn of the cochlea. The sodium, potassium, and chloride concentrations in both endolymph and perilymph were not affected. Slight and moderate congestion and regeneration of tubular epithelium of kidney were observed in guinea pigs treated with cis-dichlorodiammine platinum.

Animals↗
PubMedDate not supplied

Chronic cyanide exposure--A biochemical and industrial hygiene study.

A study was undertaken to assess the health status of workers exposed to cyanide fumes and cyanide aerosols in one of the local factories. Cyanide levels in the breathing zone and the working atmosphere were measured. Cyanide and thiocyanate concentrations in blood and urine were determined colorimetrically. The cyanide and thiocyanate concentrations in blood and urine of exposed workers were much higher than those of control workers. Smokers had higher concentrations than nonsmokers. The highest values of cyanide were found to be 0.8 and 0.2 mg/m3 in the breathing zone and general workroom atmosphere respectively. In spite of such low values, the workers complained of typical HCN poisoning. It is suggested that MAC values of 5 mg/m3 (in terms of CN) should be reviewed in respect to conditions in India.

Adult↗