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Biomedical subjects

B N Man'kovskiĭ

Publications and source records attributed to B N Man'kovskiĭ.

9 recordsLinked to original sources
PubMed2006

[The immunity during the pre-clinical period of type I diabetes mellitus].

The purpose of the study was to investigate the condition of immunity (blood lymphocyte immune phenotype and ultrastructure) in healthy children with a family background of type 1 diabetes mellitus (DM 1) having or not having diabetes-associated autoantibodies (DAAB). The subjects of the study were divided into three groups. Group 1 consisted of 90 children with a family background of DM 1 (first line relatives had DM 1), DAAB- (GADA, IA-2A, and IAA) positive or negative; group 2 consisted of 51 children with newly revealed DM 1; group 3 included 45 healthy controls, normoglycemic DAAB-negative children with no family background of DM 1. GADA, IA-2A, and IAA titers were measured using radioimmunoassay. The immune phenotype of lymphocytes (CD3+, CD4+, CDr8, CD20+, and CD56+ cells) were studied using flow cytometry (FACS-analysis); their ultrastructure was studied by means of electron microscopy. The study found a significantly lower total number of T-lymphocytes (CD3+ cells), T-helpers/inductors (CD4+ cells), and natural killer cells (CD56+ cells and large granule-containing lymphocytes) in the DAAB-positive children vs. the DAAB-negative ones and especially the controls. In the DAAB-positive children, electron microscopy found distinct changes in the ultrastructure of CD4+ lymphocytes and large granule-containing lymphocytes (CD56+ cells), which evidences changes in the secretory and cytostatic function. Such changes in the number and ultrastructure of these lymphocyte subpopulations are found in patients with newly revealed DM 1. Thus, immune changes happen in the organism of a healthy person a long time before clinical manifestations of DM 1 develop; these changes reflect a concealed autoimmune process in Langerhans islets. Detection of DAAB plays a significant role not only in studying poorly understood pre-diabetes nature, but also in the development of new, scientifically based methods of its prevention and treatment.

Adolescent↗
PubMed2000

[Blood plasma level of insulin and sensitivity to it in tissues of patients with newly detected diabetes mellitus type II].

Type II diabetes mellitus is the most common type of the condition. But little is yet known about mechanisms responsible for its development in persons with different body masses. We studied blood plasma levels of insulin and assessed sensitivity to it in 32 patients with freshly detected type II diabetes mellitus with normal and above normal body weight. Of these, 20 subjects were obese, the other 12 being not fat; the control group comprised 30 persons obese and non-obese, with n = 15 and 15 respectively. Recordable in patients was a marked elevation of blood plasma level of insulin accompanied by decrement of the peripheral tissue sensitivity to it in obese diabetic patients while in those persons with normal body mass there was a substantial reduction in the production of insulin, which differences may indicate different pathogenesis of development of type II diabetes mellitus in persons with different body masses.

Body Mass Index↗
PubMed1999

[A drug test with indomethacin in the diagnosis of subclinical forms of diabetic nephropathy].

A study was made of the glomerular filtration rate (GFR) under medicamentous loading with indometacin in 60 patients with insulin-dependent diabetes mellitus without apparent clinical signs of diabetic nephropathy (DN) with the purpose of finding ways of applying the given method for early diagnosis of subclinical stages of nephropathy. 49 patients revealed II to III stage DN as to Mogensen C. E. classification, characterized by hyperfiltration and microalbuminuria. Lack of adequate response to intake of indometacin manifested by an increase in the initially high GFR was recordable in 66% of patients with stage II DN and in 56% of those with stage II DN. Thus, indometacin test can be recommended for use as an additional method of early diagnosis of preclinical stage DN in patients with increased GFR.

Adolescent↗
PubMed1991

[The effect of sermion on brain function in diabetics].

The vasoactive drug sermion was used for the treatment of patients suffering of diabetes mellitus with clinical manifestations of central neuropathy. A course of sermion treatment effected positively the clinical course of neuropathy also confirmed electroencephalographically and by the parameters of visual and somatosensory evoked potentials of the brain. Results indicate the possibility of using sermion in the treatment of brain affections in patients with diabetes mellitus.

Adult↗
PubMedDate not supplied

[Prevalence and risk factors for the development of diabetic neuropathy].

Neuropathology is one of the most commonly encountered complications of diabetes mellitus. But we are lacking in exact estimates of the nervous system affliction incidence rates in patients with diabetes mellitus in countries of the Commonwealth of Independent States. Our objective in this work was to study prevalence of diabetic neuropathy and to identify factors predisposing to formation of the above complication of diabetes in the Prednistrovye Region of Moldova. Overall 250 patients with diabetes mellitus were examined. Relatedness has been revealed of the degree of peripheral neuropathy to the level of glycated hemoglobin (Hb(AIc)) reflecting the condition of long-term compensation of diabetes mellitus, with interrelation having been established of progression of the above distress degree of severity, with duration of diabetes mellitus, blood plasma reduction in the content of high-density lipoproteins, augmentation of low-density lipoproteins and triglycerides as well. High incidence of neuropathy attests to the need for us to carry out special medical and social measures aimed to improve the therapy of patients with diabetes mellitus and to early recognize the distress in order that we might lessen the risk for development of chronic complications of disease.

Adolescent↗
PubMedDate not supplied

[Brain function in diabetics].

Nervous system lesion is a frequent complication of diabetes mellitus. The article presented quantitative characteristics of the bioelectrical activity of the brain and analyzes integrative frequency parameters of electroencephalogram. Functional indices of brain were shown to be worsened in diabetics as compared to healthy persons. The changes in bioelectrical activity of the brain were found to be more pronounced in patients with longer history of the disease as well as in those who had specific diabetic microangiopathies. The EEG parameters in patients with insulin-dependent diabetes mellitus were poorer than in persons suffering from non-insulin-dependent form of the disease. Features of the functional brain disorders in diabetes are discussed.

Adolescent↗