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Biomedical subjects

B N Sofronov

Publications and source records attributed to B N Sofronov.

At least 19 recordsLinked to original sources
PubMed1991

[Detection of antibodies to adipose tissue cell membranes in human blood].

In serum of some healthy women and patients with fibroadenomatosis of the mammary gland antibodies to the cell membranes of adipocytes were detected. Interconnections between these antibodies and corresponding antigens in blood, on the one hand, and hormonal-metabolic status of probands, on the other hand, were observed. Possible autoimmune origin of phenomenon detected and its relation to the normal and pathological processes in adipose tissue are discussed.

Adenofibroma↗
PubMed1991

[The anti-idiotypic response to the experimental administration of the inactivated or live influenza virus].

The injection of inactivated and live influenza virus into rabbits induces the formation of anti-idiotypic antibodies, appearing after anti-influenza hemagglutinins, in the blood. The presence of immune complexes antibody--anti-idiotypic antibody in the blood of the animals has been established. The booster immunization of the animals with influenza virus antigens produces a rise in the levels of both idiotypic and anti-idiotypic antibodies. The injection of autologous anti-idiotypic globulin into the primed animals ensures the induction of idiotypic and anti-idiotypic revaccinal reactions.

Animals↗
PubMed1991

[Cellular and humoral cytotoxicity indices in children with glomerulonephritis].

Altogether 35 children suffering from different forms of glomerulonephritis were examined. It has been shown that in the pathogenesis of glomerulonephritis in children, an appreciable role is played not only by the action of pathogenic immune complexes but also by the mechanism of antibody-dependent cytotoxicity due to K-cells and lymphocytotoxicity, influencing the regulatory subpopulations of immunocompetent cells and acting directly on the structures of renal tissue. The nephrotic syndrome is characterized by the enhancement of serum lymphocytotoxicity whereas the nephritic syndrome by a rise in the blood of circulating immune complexes. In view of the fact that the process may become chronic, the rise of the activity of K-cells, of the level of lymphocytotoxins and the absence from the serum of circulating immune complexes should be regarded as unfavourable prognostic criteria.

Adolescent↗
PubMed1990

[Effects of T-activin on the course of ischemic heart disease in cases of the development of sensitization to apoprotein B-containing lipoproteins].

A comprehensive clinicoimmunological examination was made of 105 male patients aged 35-65 years who suffered from coronary heart disease. The authors identified a group of 33 patients whose unstable course of angina pectoris was associated with pronounced apolipoprotein B sensitization, as well as with the presence of the autoimmune lipoprotein-antibody complex and abnormalities in the cellular link of immunity. All 33 patients received antianginal agents. Out of them, 15 patients took additionally a course of T-activin therapy to modulate immunological shifts. The results of the examination demonstrated that the immunomodulator exerted a beneficial effect both on the course of CHD (reduction in the number of anginal episodes, improvement of left ventricular contractility) and the immune system (recovery of T-suppressor function, disappearance of lipoprotein sensitization, decrease in the patient's blood detection rates of the autoimmune lipoprotein-antibody complexes from 83 to 28%). The highest effect was reached by T-activin 1.5-2 months following termination of the course therapy. Immunomodulating therapy is regarded as an additional approach to the treatment of CHD patients with marked lipoprotein sensitization.

Adjuvants, Immunologic↗
PubMed1987

[Evaluation of the dynamics of serum immunoglobulins in suppurative surgical diseases and severe trauma].

Serum immunoglobulins G, A, M were studied along with a parallel investigation of the laboratory indicators of the destructive-inflammatory process and other indices of organism reactivity in 378 patients with acute and chronic pyo-inflammatory diseases and a critical mechanical trauma. Such an approach allowed an objective substantiation of the dynamics of serum immunoglobulins to be given. They may be recommended as prognostic criteria for the selection of curative tactics and assessment of quality of the surgical and conservative treatment.

Adolescent↗
PubMed1984

[Dynamics of the formation of anti-idiotypic antibodies in the course of the immune response].

The work demonstrates that after the injection of a heterogenous antigen into rabbits the appearance of antibodies is followed by the "spontaneous" formation of anti-idiotypic antibodies. These anti-antibodies, detected by means of several serological reactions, are specific and have an idiotypic character. Circulating antibody--anti-idiotypic antibody complexes have been detected in the blood of the animals. The injection of autologous anti-idiotypic antibodies into the immunized animals ensures the stimulation of the formation of antibodies and anti-idiotypic antibodies. Immunological memory with respect to anti-idiotypic antibodies develops in the body of the immunized animals.

Animals↗
PubMed1983

[Complement consumption as criterion of the tolerogenicity of a globulin preparation].

Experiments on mice (296 animals) were made to study the capability of native and deaggregated preparations of human globulin to fix complement as well as the relationship of this indicator to tolerogenic properties of the preparations in question. Ultracentrifuged preparations were discovered to have the decreased capability to activate complement. As anticomplementary properties of the preparations become more demonstrable their tolerogenicity declines. The decreased capability to activate complement can be used as criterion in screening tolerogenic preparations.

Animals↗
PubMed1980

[Comparative action of the low-molecular fractions from thymus and cerebral cortex polypeptides on the immune response in mice].

Rabbit antisera against low-molecular weight polypeptides from the thymus (thymosin and thymarin), brain cortex (cortexin) and white matter of the calf brain were cross absorbed with these polypeptides and tested in the complement fixation test with the above preparations. In addition they were also tested in the complement-dependent cytotoxicity test with thymocytes and bone marrow cells. Thymosin, thymarin and cortexin were shown to be antigenously similar but to differ in antigenous structure from the polypeptide of brain white matter. The biological effect of the polypeptides from the thymus and brain cortex is related to the thymus-dependent lymphocyte population rather than to B cells. Cross absorption has revealed that antisera against the polypeptides from the thymus and brain cortex contain antyibody both against common antigens and antigens specific only for the appropriate preparation. The antigenous set of thymarin responds better to thymic antigens than cortexin.

Animals↗
PubMed1979

[Role of T- and B-cells in immunologic memory and the prolonged production of antibodies in the body].

The role of T and B cells in the immunological memory and prolonged antibody production in mice was studied; for this purpose CBA mice were immunized with SRBC in doses of 1 X 10(6) or 1 X 10(9) cells, decapitated 21--25 days later, and their spleen cells were treated with T or B antiserum and transferred in a dose 7 x 10(7) cells to syngeneic recipients treated with cyclophosphamide for suppressing their immunity. The treatment of the donor spleen cells with T or B antiserum resulted in a considerable decrease in the hemagglutinin level, as well as in the number of IgM- and IgG-forming cells. The transfer of T and B cells, mixed in equal amounts, to syngeneic recipients restored the immunological memory of the animals; in those cases when the mixture had the prevalence of T cells the restoration of the immunological memory was even more pronounced. The donor spleen cells treated with T or B antiserum, when tested for their ability to produce IgM- and IgG-forming cells in vitro (prior to their transfer to the recipient), showed a decrease in the production of IgM-forming cells (68%) and IgG-forming cells (74%) only under the action of B antiserum, whereas T antiserum had no influence on the production of IgM- and IgG-forming cells in vitro.

Animals↗
PubMed1978

[Effect of highly purified thymus factor on the cellular and humoral indices of immunity in thymectomized mice].

Effect of homogeneous polypeptide thymus factor of mol weight about 5000 (thymarin-III) on cellular and humoral immune responses of thymectomized adult CBA mice was studied. Thymectomy proved to greatly decrease the number of T-cells in the spleen. Accordingly, the capability of these mice to produce both IgM and IgG antibody-forming cells in response to the thymus-dependent antigen (sheep red blood cells) was significantly depressed. Subcutaneous injections of thymarin-III (1 microgram per g of body weight) for 7 days completely restored the T-cell spleen population and normalized the animals' immune response.

Agglutinins↗