STUDIES ON THE VARIATIONS ON SERUM TOTAL CHOLESTEROL AND C/P RATIO IN RELATION TO DIETARY FAT INTAKE IN SUBJECTS SUFFERING FROM ATHEROGENIC AND NON-ATHEROGENIC PATHOLOGICAL CONDITIONS.
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Biomedical subjects
Publications and source records attributed to B NAGANNA.
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The serum of a case of hyperglobulinaemia with negative thymol and zinc sulphate turbidity reactions was studied. The serum when added to pathological sera with high turbidity values brought about a marked reduction in the original turbidity values. Also, the serum did not give the usual copper proteinate precipitate when added to copper sulphate solutions. The anomalous protein fraction responsible for the above properties was isolated from the gamma globulins by precipitation at 28% saturation with ammonium sulphate. It was found to be neither a macroglobulin (Waldenstrom's), a cryoglobulin, nor a collagen protein. Its occurrence in the very gamma globulin fraction which is responsible for many of the turbidity reactions is of great significance in the interpretation of these tests. It is suggested that the normal turbidity and flocculation reactions reported in some cases of multiple myelomatosis might be due to some such anomalous proteins.
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