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Biomedical subjects

B Nabarra

Publications and source records attributed to B Nabarra.

15 recordsLinked to original sources
PubMed1979

Recurrence of dense deposits in transplanted kidneys: I. Sequential survey of the lesions.

Serial specimens from transplanted kidneys were obtained in 11 patients with dense deposit disease (DDD). The recurrence of DDD was obvious in 9 patients and appeared very early after grafting. Three different types of evolution of the lesions were observed. In 4 patients no modification of the lesions occurred with time, and in 2 of them the dense alteration alone persisted without any other glomerular changes. In 3 patients a progression of the lesions was observed, whereas a regression occurred in 1 other patient. From these observations the following sequence of the morphologic changes can be proposed: the dense alteration appears first and constitutes the specific marker of that disease; the C3 deposition in the kidney occurs later following the appearance of the dense lesion.

Basement Membrane↗
PubMed1979

Morphological study of autologous rosettes (A-RFC).

The morphology of autologous rosette forming cells (A-RFC) has been studied by light and electron microscopy. Autorosette forming cells were obtained from the spleen of adult thymectomized (ATx) or nude mice, and from neonatal thymus grafts during the regeneration phase. Among the autorosettes seen by light microscopy, 76% of them were formed by lymphoid cells which included a high proportion of large lymphocytes (48%). Electron microscopy study performed after isolation of A-RFC by micromanipulation demonstrated that 74% were formed by large lymphoid cells with an immature nucleus. The finding of such large-sized lymphoid cells with immature nuclei is in agreement with our previous results indicating that A-RFC might belong to an immature T cell class.

Animals↗
PubMed1979

[Histological and ultrastructural study of intestinal ganglioneuromatosis. The multiple endocrine neoplasms type IIb syndrome].

The syndrome known as the Multiple Endocrine Neoplasia type III or type IIb presents a particular histological intestinal lesion: hyperplasia of the myenteric plexus. The electron microscopic study of the plexus of Auerbach in our observation suggests a disequilibrium of the different types of individual axonal sheaths compared to the descriptions of a normal plexus. The possible role of this anomaly in the genesis of intestinal manifestations in this syndrome is here discussed.

Female↗
PubMed1977

Ultrastructural study of spontaneous bone marrow rosette-forming cells.

Mouse bone marrow contains spontaneous rosette-forming cells (RFC) which include more than 70% T-cell precursors, as assessed by their transformation into theta-positive cells after incubation with thymic hormone. Such spontaneous RFC, examined in C57B1/6 mouse bone marrow by electron and scanning electron microscopy, have consistently been shown to be small, inactive mouse lymphocytes when macrophages have been eliminated by cell preincubation. These data suggest that thymic hormone target cells include small quiescent lymphocytes.

Animals↗
PubMed1977

Ultrastructure of a polysome-lamellae complex in a human paraganglioma.

Study of a human abdominal paraganglioma under electron microscopy revealed an unusual cytoplasmic inclusion appearing as a hollow cylinder made up of one or several concentric lamellae surrounded by single or aggregated granules. Cross sections of the lamellar element show a discontinuous juxtaposition of particles. It is moderately dense and is bordered by 140--to 250-A granules of sure ribosomal nature. The inclusion is closely connected to the rough endoplasmic reticulum. The origin and significance of this complex are discussed.

Abdominal Neoplasms↗
PubMed1977

Glomerular changes in patients with cirrhosis of the liver.

Deposits with IgA as the main component frequently are found in the glomeruli of patients with cirrhosis of the liver. These deposits usually are latent. In some cases, however, they may be associated with proliferative changes and clinical manifestations of glomerular involvement.

Adult↗
PubMed1976

Susceptibility and resistance of Candida to 5-fluorocytosine in relation to the cell wall ultrastructure.

Studies on the susceptibility of Candida albicans to 5-fluorocytosine (5FC) demonstrated a high rate of resistance (85%) for serogroup B strains, more frequently isolated in Africa, and a low incidence (<1%) for serogroup A, predominating among Whites (Drouhet et al., 1974). Determination of the electrophoretic mobility of various strains did not provide a correlation between the charged groups of the surface and their phenotype to 5FC and antigenic groups. Adsorption of the surface antigens with a hyperimmune antiserum did not modify the phenotypic expression of Candida to 5FC. Electron microscopy studies revealed that susceptible strains had an additional granular layer dividing the inner stratum into two parts. After trypsin digestion of these strains, the disappearance of this layer was concomitantly associated with the emergence of resistance. Thus, it appears that the cell wall contains a proteinic material, which is located in the interior of the electron-transparent region and acts in the metabolism of 5FC.

Animals↗
PubMed1976

Ultrastructure of cells infiltrating human kidney allografts.

Cell infiltration is commonly observed in human renal allograft biopsies. This infiltration was investigated using electron microscopy for a more precise assessment of the nature of these cells. More than 3000 cells infiltrating twenty-five renal allograft biopsies were studied. Six cellular types were distinguished and a mean percentage of each type was calculated. Only one-half of these cells were normal or transformed lymphocytes (including small lymphocytes: 22-3 +/- 3-8%, 'intermediary' cells: 22 +/- 3-6%, blast-like cells similar to MLC transformed lymphocytes: 8-1 +/- 2-4%. A relatively high number of plasmocytes (12-4 +/- 2-5%) and a still higher percentage of macrophages (28-5 +/- 4-6%) were found. Granulocytes represented only 2 +/- 0-8%of the cell population. Variations of the mean percentage of these cellular types were studied in various clinical situations.

Cell Movement↗
PubMed1975

[Sensitivity and resistance of Candida to 5-fluorocytosine. Relationship to the cell wall ultrastructure].

The study of ultrafine sections of the yeasts of Candida show a difference in the cell between sensitive and resistant strains to 5-fluorocytosine (5-FC). The sensitive strains show a thin border of granular material inside of the clear internal layer which is absent for the majority of resistant strains. After trypsinization, the sensitive strains show a resistance which is reversible and the granular layer disappears. These data permit the conclusion that the middle layer of resistant strains is of protein nature and interferes with the metabolization of 5-FC.

Candida↗
PubMed1975

In vitro culture of functional human thymic epithelium.

Cultures of pure epithelial cells have been obtained from human thymus. Incubation of spleen cells from adult thymectomized mice on these cultures rendered RFC sensitive to inhibition by anti-theta serum, whereas no effect was obtained with fibroblasts or spleen cell cultures. The fact that theta conversion was obtained when spleen cells were incubated in the thymic culture placed within a Millipore chamber indicates that theta conversion was due to the effect of a humoral factor.

Animals↗
PubMedDate not supplied

[Concerning 490 renal transplants in the rat, Technical study (author's transl)].

The authors carried out 490 renal transplants in the rat, in order to train two laboratory technicians with no previous surgical competence, in this microsurgery. The different techniques of vascular and urinary anastomoses are looked at with their advantages and disadvantages. Two years were necessary in order to obtain a percentage of immediate success of 75 per cent. But, secondary infections and mainly urinary complications in this experiment, prevent obtaining more than 50 per cent of graft which could be exploited on a long term basis, which limits the scientific value of the method.

Animals↗