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Biomedical subjects

B O Maehle

Publications and source records attributed to B O Maehle.

At least 37 records · Page 2Linked to original sources
PubMed1988

Breast cancer: young, old, and very old. A preliminary report.

A new method of characterizing breast carcinomas is presented that may help further our understanding of this disease. A tumour age coefficient is described, derived from tumour diameter and the mean nuclear area of the tumour cells, the latter a measure of tumour growth rate. On this basis a series of 213 operative infiltrating breast carcinomas is divided into 3 tumour age groups (young, old, and very old). These are then related to axillary nodal status and the patient's age at operation. The likelihood of nodal spread is shown to increase with tumour age. This is interpreted as an expression of a build-up of tumours that have spread with time. There was no set tumour age by which metastatic spread could be expected, but some indication of a lower age limit.

Adult↗
PubMed1988

A link between malignant melanoma and cervical intra-epithelial neoplasia? A preliminary report.

The risk of malignant melanoma was found to be six times as great in a group of 805 patients with cervical dysplasia as in case-matched controls. In the latter it was similar to that in the general population. In keeping with this observation a further series of 13,030 women with no record of cervical intra-epithelial neoplasia showed a slightly lower risk than that expected in the general population. Conversely in a small group of women (71) with melanoma the risk of cervical intra-epithelial neoplasia was nine times as great as in the general population; judged on the basis of both case-matched and 'first smear' controls. The possibility of a common risk factor is discussed.

Cross-Sectional Studies↗
PubMed1988

Cervical lesions in patients with malignant melanoma.

Koilocytes were found in the cervical epithelium in association with cervical intra-epithelial neoplasia in 8 out of 9 cases of malignant melanoma. This suggests that the cervical lesion in them was of viral origin. In 62 women with malignant melanoma but without cervical atypia there was also an excess of koilocytosis compared with controls with neither lesion. These findings point to the possibility that human papilloma virus infection may also be involved in the development of malignant melanoma, as it has been shown to be in cervical intra-epithelial neoplasia.

Cervix Uteri↗
PubMed1988

Prognosis in node negative breast cancer patients: the importance of tumour diameter and mean nuclear area.

In node negative breast cancer patients, tumour size and mean nuclear area (MNA) as single variables have significant impact on prognosis. Combination of the two variables gives additional information on survival, and makes it possible to predict the outcome of the disease correctly in 70% of the patients both early (82 months) and late (154 months). MNA contributes relatively more to prediction of late prognosis than tumour diameter and vice versa for early prognosis. Thus a long follow-up is needed for node negative patients, and more so for patients with favourable prognostic criteria.

Breast Neoplasms↗
PubMed1988

Differences in the occurrence and age distribution of lesions in other organs in women with/without cervical neoplasia.

Over a 5 1/2 yr study period lesions leading to biopsy were reported in 902 of 3.937 women (23%) with a record of cervical neoplasia, compared to 1,142 of 13,030 controls (9%). This applied irrespective of the severity of the cervical lesion. In women with a record of cervical neoplasia, again irrespective of the severity of the lesion, relatively more lesions were seen in other organs in the younger age groups (45 yrs and less). In contrast the number of such lesions increased with age in the controls. While the present study gives no indication of the possible nature of the implied link between cervical neoplasia and the other lesions involved, it is suggested that the possibility of a common virus aetiology should be explored.

Adolescent↗
PubMed1987

Size of breast carcinomas at operation related to tumour growth rate.

The mean nuclear area (MNA) of breast carcinoma cells, previously shown to be related to prognosis, is here presented as a potential overall measure of tumour growth rate prior to operation. Recording of tumour diameter and MNA in 340 infiltrating breast carcinomas demonstrated that tumours of low MNA tended to present at a lower diameter that those of high MNA. The former have thus remained 'small' over a longer period, giving the woman more time to report them at this stage. It is suggested that mass screening from breast carcinoma may pick up these slow growing tumours, missing those of high growth rate unless the screening interval is correspondingly short.

Breast Neoplasms↗
PubMed1984

Prediction of prognosis in axillary lymph node positive breast cancer patients: a statistical study.

This work has identified variables of importance to short- and long-term prognosis in 97 node positive breast cancer patients followed for a minimum of 98 months. The diameter of the primary tumour (less than or equal to 3 cm/greater than 3 cm) is shown to be an important prognostic variable. Its addition to the presence/absence of tumour cells in the efferent nodal vessels and the mean nuclear area of the tumour cells gave correct prediction of the disease outcome, 60 and 98 months after the operation, in 83 and 80 per cent of the patients respectively. Although the number of tumour-bearing nodes is shown to be a strong variable, more information was gained from the tumour diameter. Histological grade was only of value for 5-year prognosis. Factors that did not add information of prognostic value in these circumstances were identified. The proposed models demonstrate the great heterogeneity within this group of patients.

Adult↗
PubMed1984

Prognostic evaluation in node-positive breast carcinoma: stage versus growth rate.

The range in survival time in operable node-positive breast carcinoma is considerable. Postoperative management is thus dependent on accurate prognostic assessment. This involves the choice of relevant prognostic factors. Theoretically these should include measurements of both stage and growth rate. In a series of 96 cases it is demonstrated that the diameter of the primary (3 cm and under/over 3 cm) can be used as a measure of tumour stage; the histological grade of the primary as one of tumour growth rate; and the presence/absence of tumour cells in the efferent nodal vessels (EVI status) as a measure of nodal stage. The latter is proposed as an alternative to the number of tumour-bearing nodes recovered from the axilla. Division of the cases on this basis was sufficient to assess high or low risk using routine histological methods.

Axilla↗
PubMed1983

Prognosis in breast cancer patients with tumour cells in the efferent vessels of their axillary nodes.

The presence of tumour cells in the efferent vessels of the axillary nodes of breast cancer patients is termed efferent vascular invasion (EVI). The EVI status had been recorded in 112 cases which have now been followed for a mean of 120 +/- 8 months. At the start of the 10th year 17 per cent. of the EVI positives cases were alive, compared to 54 per cent. of the EVI negative. The EVI status has thus strong prognostic implications. It can be recorded in association with primary treatment on routine histological examination. No special equipment is required.

Axilla↗
PubMed1983

Sinophobic growth in oestrogen receptor-negative metastatic breast cancer.

The mode of growth of tumour cells from primary breast carcinoma in the axillary nodes is shown to be related to the oestrogen receptor (ER) status of the primary tumour. ER-positive primaries are described as tending to show sinophilic growth, the tumour cells spreading along the nodal sinuses; while the ER-negative are sinophobic, spreading more diffusely in the lymphoid tissue.

Axilla↗
PubMed1983

On the progressive nature of tumour growth in the axillary nodes in breast cancer.

Tumour cells enter the axillary nodes by the afferent lymphatics, but little is known about their subsequent behaviour. Quantitation and localization of tumour growth in 156 nodes suggest that the establishment of tumour growth in them is not haphazard. It starts in the cortex, extending later through the medulla, and finally into the efferent nodal vessels. This systematic growth pattern is in keeping with the unfavourable prognosis in cases with efferent vascular invasion in which both cortex and medulla are involved.

Axilla↗
PubMed1982

Concomitant neoplasia in pancreatic cancer.

An association is reported between endocrine tumors and adenocarcinoma of the exocrine pancreas. This became apparent in autopsy material from Hordaland County, Norway, between 1972-1976, but had not been seen in the preceding 15 years. It was accompanied by an increase in multiple primary cancers. On the basis of the findings in the case-matched controls, it is concluded that the increases recorded in this autopsy material are real.

Adult↗