PubMed Health⌕ Search

Biomedical subjects

B O Moore

Publications and source records attributed to B O Moore.

8 recordsLinked to original sources
PubMed1996

Hippocampal lesions cause forgetting in a spatial response task.

UNLABELLED: Monkeys with lesions to the hippocampus and overlying cortex were impaired in making a spatially selective response on the basis of a spatial cue. Their impairment was even more severe on a task in which they were required to make spatial responses on the basis of cues which are not spatially distinct. A second experiment showed that once lesioned monkeys had been trained on a task with spatially distinct stimuli, they were initially able to perform accurately if the aspatial distinctiveness of the cue was reduced. However, their performance declined to chance over four to six trials. These results suggest that lesions to the hippocampus and overlying cortex may cause impairments in memory for the arrangement of visual scenes, including the spatial location of responses. KEYWORDS: spiny neurons, direct pathway, indirect pathways, rat neostriatum

Animals↗
PubMed1994

Hippocampal lesions impair spatial response selection in the primate.

This study investigates the role of the primate hippocampus in spatial cognition. Following lesions to the hippocampus, monkeys were unable to learn to direct their responses to different locations in space, based on a spatial cue. This deficit was not due to an impairment in learning to make the responses, since lesioned monkeys were normal when these did not have to be spatially selective. Furthermore, the deficit could not have been due to an impairment in the detection of cues, since lesioned monkeys were normal in their ability to detect visual targets presented over a wide area of space. These results support the view that the hippocampus of the monkey is necessary in order to remember the spatial arrangement of visual scenes in an egocentric manner.

Animals↗
PubMed1990

Olfactory self-selection of protein-containing foods.

When one unflavored, nonprotein diet was available in two differently scented bins, rats fed a protein-free diet over four days ate more from the bin smelling of gluten, ovalbumin, yeast or fibrin, but not soy, casein or lactalbumin, than from the bin smelling of butter. Rats fed a protein-containing diet over the same four-day period had no such preference. This result demonstrates that protein-deprived rats can use odor cues in making their selection of certain proteins. Since the direction, speed, and size of preference for these protein odors, excepting soy, are remarkably similar to those previously observed when rats actually consumed the proteins, olfactory stimuli appear to elicit appropriate protein selection responses independently of other protein quality variables such as taste, texture or nutrient composition.

Animals↗
PubMed1989

Unlearned specific appetite for protein.

Appetite for most protein appears to be unlearned. Protein-depleted rats, in the first half hour of a test, chose a significantly larger proportion of soybean, gluten, zein, fibrin, yeast torula and ovalbumin than protein replete controls, but not of casein or lactalbumin. There had been no opportunity to learn such dietary preference before the test. The preference for the protein in protein-depleted rats manifested itself significantly from the first minute, and also in females in which protein need was induced by pregnancy rather than a diet different from the controls.

Animals↗
PubMedDate not supplied

An antiemetic is antidotal to the satiety effects of cholecystokinin.

Although cholecystokinin (CCK) has been proposed as a satiety agent, this property has been disputed by some who claim that the compound exerts its 'satiety' effects by inducing aversion. We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic.

Animals↗