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B Odlind

Publications and source records attributed to B Odlind.

59 records · Page 4Linked to original sources
PubMed1980

Renal tubular secretion and effects of furosemide.

Continuous intravenous infusion of furosemide (8 mg/hr) to 6 healthy subjects induced an average diuresis at steady state of 667 +/- 144 ml/30 min (+/- SD) with a mean plasma concentration of furosemide of 623 +/- 209 ng/ml. The urinary output of Cl- was 50.4 +/- 7.5, of Na+ 47.7 +/- 8.7, and of K+ 5.4 +/- 0.6 mmole/30 min. Intravenous injection of probenecid (1 gm) raised the plasma furosemide level to a maximum of 1,584 +/- 151 ng/ml. Despite this, the urinary excretion of water, Cl-, Na+, and K+ decreased to 52%, 39%, 39%, and 52%, respectively, of control values. Probenecid greatly reduced the urinary excretion and renal clearance of furosemide. There was no or negative correlation between the plasma levels of furosemide and its diuretic and saluretic effects. The urinary excretion and renal clearance of the diuretic correlated positively with these effects. No effect of probenecid on protein binding of furosemide was detected. The findings show that the diuretic effects of furosemide depend on active tubular secretion of the drug and thus on its tubular fluid concentration.

Adult↗
PubMed1978

Blood flow distribution in the renal portal system of the intact hen. A study of venous system using microspheres.

The blood flow in the renal portal system of intact hens was characterized by determining the fractional distribution of 15 microns and 50 microns microspheres in this system after injection into a leg vein. Validation tests showed that only 50 microns spheres gave reliable estimation of this distribution. The blood flow in the coccy-geomesenteric vein was directed towards the liver in nearly all cases. On the average 44, 47 and 8% of the portal blood from the external iliac vein perfused the ipsilateral kidney, the liver and the lungs, respectively. However, the distribution of portal blood to these organs varied considerably between individuals and changed appreciably within 35 min in half the animals studied. The reason for these variations is not clear. The portal blood from the right and left external iliac veins was asymmetrically distributed in most animals illustrating the importance of local factors in its regulation. Variation was great in the regional distribution of portal blood within the kidney possibly due to local vasoconstriction of portal vessels. Further information e.g. on the regulation of renal portal blood flow is needed to explain its physiological significance. Microspheres provide a convenient method for such studies. A combination of microsphere and Sperber techniques allows us to determine the renal excretion efficiency of a given substance.

Animals↗
PubMed1978

A modified Sperber technique for direct estimation of true renal tubular excretion fraction.

The Sperber technique in the hen is particularly suitable for the study of renal tubular secretion. However, results obtained with this technique vary considerably, due to an unpredictable and highly variable shunting of renal portal blood. In an attempt to get a total and stable renal perfusion by portal blood from the leg, appropriate shunt vessels were ligated. This procedure was found to force all portal blood from the leg to perfuse the ligated kidney, without affecting the symmetry of glomerular filtration or renal clearance of 125-I-Na-o-iodohippurate between the kidneys. In conclusion, the abolition of renal portal shunt flow allows use of the Sperber technique for a direct estimation of the true tubular excretion fraction (TTEF) of a substance. Thus, TTEFPAH, a measure of the tubular excretion efficiency of para-amino-hippuric acid, was found to be about 70%. The stable renal perfusion in ligated animals will also facilitate comparative studies of renal tubular excretion in the hen. Moreover, no animal has to be rejected due to a low renal perfusion of portal blood. Furthermore, the use of ligated hens makes it unnecessary to use markers for the renal perfusion of portal blood when steady-state experiments are performed. Finally, the total renal perfusion of portal blood in ligated animals will facilitate the demonstration of a secretory component in the renal handling of substances with a low affinity for the renal transport system.

Animals↗