Biomedical subjects

B P Joynt

Publications and source records attributed to B P Joynt.

5 recordsLinked to original sources

PubMed1988

Toxicology case data reporting system.

A computerized system has been organized to serve the toxicology sections of seven R.C.M.P. laboratories across Canada. Scientists may view and retrieve information concerning drugs and drug combinations, blood and liver drug concentrations, etc. from cases of sudden death or impaired driving which were analyzed in the laboratories. This has proven to be a great help in interpreting toxicology case results for the investigator or the courts and also in choosing methodology to be used in analyzing specimens for unusual drugs or poisons.

Canada↗

PubMedDate not supplied

Evaluation of current derivative spectrophotometric methodology for the determination of percent carboxyhemoglobin saturation in postmortem blood samples.

Carbon monoxide intoxication continues to be a commonly encountered cause of death in most areas of Canada. The forensic nature of the samples in these cases presents special problems that are not normally encountered in clinical determinations. A study was undertaken to assess various methods of determining the percent carboxyhemoglobin saturation in blood, more specifically, those using derivative spectrophotometric measurements in the Soret region of the UV spectrum. At the same time, other studies were carried out: the effects of storage time on the carboxyhemoglobin levels; evaluation of sample containers; comparison of percent carboxyhemoglobin saturation in blood samples taken ante-mortem and post-mortem. Blood for the study was obtained from laboratory animals that were exposed to carbon monoxide before death.

Animals↗

PubMedDate not supplied

Optimization of the EMIT immunoassay procedure for the analysis of cannabinoids in methanolic blood extracts.

EMIT assays are commonly used for the detection of cannabinoids in urine and have been widely adapted to accommodate blood samples. Over recent years, several different kits have been produced by the assay manufacturer for this purpose. The newest kit was found to be significantly less sensitive for methanolic blood extracts than kits previously available. Modifications are described to improve the sensitivity of the newer cannabinoid kit as applied to blood extracts. In addition, information is presented which demonstrates enhanced performance of this assay procedure by the use of a commercially available enzyme substrate supplement.

Cannabinoids↗

PubMedDate not supplied

Triazolam blood concentrations in forensic cases in Canada.

Triazolam has been a controversial drug since its appearance on world markets as a hypnotic more than ten years ago. Whole blood concentrations of triazolam as found in forensic cases are cited in several categories; that is, impaired driving: 17 cases; sexual assault: four cases; death due to drugs: 45 cases; drug-related death (drugs contributed to the death but were not the ultimate cause): 20 cases; drug-involved death (drugs were present but were not felt to be a contributing factor): six cases; miscellaneous: one case. The data was gleaned from a forensic toxicology database designed and used by the Forensic Toxicology Sections of the Royal Canadian Mounted Police (RCMP) laboratories in Canada. Triazolam concentrations from selected references are included for comparison.

Accidents, Traffic↗

PubMedDate not supplied

Sudden death of a heroin body packer.

This report documents an unusual case in which the analysis of postmortem specimens from a female heroin body packer revealed phenomenally high concentrations of morphine, 6-monoacetylmorphine (6-MAM), caffeine, and codeine. Several condoms containing white powder had split, emptied their contents into the stomach, and then leaked into the peritoneum through a rupture in the stomach wall. Blood concentrations were: morphine, 120 mg/L; (6-MAM), 184 mg/L; codeine, 1.7 mg/L; and caffeine, 400 mg/L.

Codeine↗