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Biomedical subjects

B Palos

Publications and source records attributed to B Palos.

6 recordsLinked to original sources
PubMed1983

Combined continuous ultra low dose rate irradiation and radiofrequency hyperthermia in the C3H mouse.

Intradermally inoculated RIF tumors and normal skin of male C3H mice were implanted with variable activities of Iodine 125 seeds or dummy seeds enclosed in Vicryl sutures, and subjected to 0, 1, 2 or 3 local radiofrequency heat treatments for 30 minutes. Each treatment raised the tumor volume to 44 degrees C. Gastrointestinal toxicity (assessed by weight change), skin reaction, tumor growth delay, and tumor cure were assessed. Neither radiofrequency treatment alone or continuous ultra low dose rate irradiation up to 16,000 rad over 180 days alone was successful in curing these tumors; however, combined modality treatments employing doses as low as 8,000 rad over 180 days plus two radiofrequency treatments did effect cures. Gastrointestinal toxicity was best correlated with hyperthermia treatments, while skin reactions secondary to hyperthermia were prolonged by continuous ultra low dose rate irradiation. Implications for clinical usage are discussed.

Animals↗
PubMed1980

Brachytherapy renaissance.

During the last 2 decades, the introduction of new isotopes for both removable (192Ir) and permanent (125I) interstitial implants, along with the availability of computerized dosimetry and the refinement of implantation techniques have all contributed to a Renaissance of brachytherapy. Techniques of implantation and the results of such procedures at the Stanford Medical Center for the 3 most commonly implanted carcinomas (breast, prostate, head and neck) are all presented in detail. Other anatomic sites which may be treated by interstitial irradiation are also described.

Brachytherapy↗
PubMed1976

The metal/tissue interface effect in irradiation of the oral cavity.

Metal dental prostheses or overlays may lead to increased mucosal reactions of adjacent tissue surfaces during intensive irradiation of the oral cavity. The dosimetry of this phenomenon was investigated by irradiating dental phantoms with 4-and 6-MeV photons. Gold and amalgam interfaces may produce local mucosal doses as high as 150-170% depending on the beam geometry, but doses of 111-126% for gold crowns and about 109-118% for amalgam fillings were found for opposed-beam configurations. 2-4 mm of tissue-equivalent absorber is sufficient to re-establish a homogeneous dose distribution and should be employed throughout therapy whenever dental extraction is unwarranted. The radiobiological exaggeration of the interface effect in treatment with opposed beams using one field per day is discussed.

Absorptiometry, Photon↗