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B Paramelle

Publications and source records attributed to B Paramelle.

At least 73 records · Page 4Linked to original sources
PubMed1980

[Pneumoconiosis due to amorphous silica smoke. Mineralogical and ultrastructural study of 6 cases (author's transl)].

Pneumoconiosis was diagnosed in 10 patients working in a silicon factory. The exposure time varied between seven and thirty-five years. All patients had only slight or no symptoms, except one presenting an important dyspnea. The radiologic study showed an interstitial syndrome. The functional lung test revealed a restrictive syndrome. Seven patients underwent fibroscopy with alveolar washing and transbronchial biopsy. A surgical biopsy was performed in two patients. The histological lesions showed an accumulation of alveolar and interstitial macrophages and the existence of fibrous interstitial micronodules. The ultrastructural study revealed an interstitial fibrosis. The macrophages contained numerous dense, homogenous small spheres of amorphous structure, composed of silicon and oxygen. These spheres represent amorphous silica smoke particles. Less than 1% of the particles are crystalline silica. Thus, the amorphous silica particles seem to be responsible for the histological and radiological lesions observed.

Humans↗
PubMed1980

[Lymphomatoid granulomatosis: anatomo-clinical and ultrastructural study of two observations (author's transl)].

Two anatomoclinical observations of lymphomatoid granulomatosis are reported. The first case concerns a patient presenting a cutaneous localisation and a severe pulmonary infection with acute febrile dyspnea and macronodular opacities seen in pulmonary radiographs. The treatment associating cortisone and chlorambucil led to a complete remission. Five years later a pulmonary recurrence was treated successfully with the same association. The second patient presents dyspnea upon progressive effort, a radiologic and functional syndrome of interstitial involvement. In the absence of precise diagnosis after pulmonary biopsy, the patient was treated with corticosteroids. Four months later, encephalitic damage led to death. In the 2 observations, the biopsies or autopsic samples from the lungs or brain showed necrotic nodular lesions. Bordering on the necrosis, the small arteries and veins are strictured or obstructured by an infiltrate of lymphocytes, plasmocytes, histiocytes, and large cells with atypical nucleus. The ultrastructural examination of the 2 pulmonary biopsies shows the reactional polymorphic nature of the lymphoid infiltrate, the generally imprecise nature of atypical large cells and the modifications of vascular elastic limitations. The blades of elastine are surrounded by microfibrillar material. These different data are compared with those in the literature.

Adult↗
PubMed1979

[A case of thymolipoma in a child (author's transl)].

A new case of asymptomatic thymolipoma in a 4.5 years old girl is reported. It was discovered during systematic medical investigation. Its radiological characteristics and the lack of evolutivity made the authors suspect the diagnosis before operating. A total surgical extraction of the 300 g weighing tumor was performed through a right thoracotomy. No complication occurred in the post-operative time. Others authors already indicated the scarcity of this affection (less than 10 cases in children) as well as the special radiological characteristics of this tumor and the noticeable clinical tolerance often despite a large bulk. Histologically the tumor is made of an infiltrating of the normal thymic tissue by proliferating adipose adulte cells, the benignity of which is demonstrated by the evolution. In this study a differential diagnosis between thymolipoma and other mediastinal tumors is made and also some pathogenic assessments. Surgery always is required for treatment.

Child, Preschool↗
PubMed1978

Cytological survey of bronchial brushings and aspirations performed during fiberoptic bronchoscopy.

In this series of 342 cases of bronchial carcinoma diagnosed by fiberoptic cytology (brushing and aspiration), comparison with the endoscopic findings gave the following results:--As regards primary carcinomas, 91 per cent of the cases in which the tumour was visible had a positive cytology when brushing was used and 84 per cent with aspiration. 79 per cent of the cases with no visible tumour but with suspicious changes of the bronchial wall had a positive cytology with brushing and 71 per cent with aspiration. When no abnormality could be seen by fiberoptics, positive cytologies dropped to 47 per cent and 50 per cent respectively.--In case of metastatic carcinoma the results are not as good. However, brushings gave 87 per cent positivity when the tumour was visible with the fibroscope and aspiration 75 per cent. Such cases are rather unfrequent unfortunately. Suspicious lesions at the fibroscope examination yielded respectively 68 and 64 per cent positivity. While in cases with no abnormality seen with the fibroscope brushings gave a 29 per cent positivity and aspirations a 25 per cent. No false positives were made. Correlation with histology and comparison with sputum cytology will be commented upon.

Bronchoscopy↗
PubMed1977

[Short and long term behaviour of pleural effusion cultures. (Report of 200 cases) (author's transl)].

Pleural effusions from 200 patients with benign or malignant pleural involvement have been cultured in vitro and observed from 48 hours to 9 months. The morphology and "social behavior" of the different types of cells are described. Mesothelial cells settle down quickly and come into contact with each other by long cytoplasmic processes. The tendency of epithelial malignant cells is to clump and grow in clusters. These "balls" of varying size are freed into the culture medium. Similar clusters may be found in benign effusions showing mesothelial hyperplasia. In case of malignant primary tumor of the pleura, the morphology of cultured cells is similar to that of mesothelial cells. In 3 cases, typical malignant epithelial cells have allowed us to discard the diagnosis of malignant mesothelioma. Discrepancies between conventional cytology and cell culture were found in 13 cases: in 6 cases, positive for malignant cells using conventional cytology, cell culture was negative. In 7 cases with negative routine techniques, cell culture disclosed malignant cells. Large multinucleated syncytia were observed in 15 cultures. They suggest a cytopathic effect similar to that seen in myxovirus infected cells. Correlation with the etiology of pleural effusions in these cases is described.

Cells, Cultured↗
PubMed1976

[Respiratory function in chronic obstructions of the large pulmonary arteries (study of 30 cases].

If diagnosis of chronic thromboses of pulmonary arteries is usually easy at the stage of confirmed chronic pulmonary heart, it is not so when dysponea is the only symptom of the disease. The authors report 30 cases of chronic thrombosis and remark that if respiratory alkalosis is very frequent, hipoxemia is often missing. On the other hand they observe 27 times out of 28 an increase of CO2 alveoloarterial difference; measuring the CO2 difference appears a safe and reliable test for detecting chronic thrombosis. It should take place in every systematic complete examination of unexplained dyspnoea.

Adult↗
PubMed1976

[Aspiration-drainage of an emphysematous bulla in a patient with severe respiratory insufficiency].

The authors report the case of a patient with severe alveolar hypoventilation, with a large emphysematous bulla in the upper part of the right pulmonary field. The drainage aspiration of the bulla as a life saving technique greatly improved the respiratory function. Blood gases reverted to normal and the bullae disappeared. Literature reviewing. Discussion of radiological and functional criteria of compressing the pulmonary parenchyma around the bulla.

Adult↗