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Biomedical subjects

B Petrini

Publications and source records attributed to B Petrini.

At least 109 records · Page 6Linked to original sources
PubMed1985

Persistent generalized lymphadenopathy: immunological and mycological investigations.

Immunological and mycological investigations were carried out in 21 Swedish homosexual males. One of them had AIDS, one pre-AIDS and 19 lymphadenopathy of whom 18 fulfilled the criteria of persistent generalized lymphadenopathy (PGL) as defined by the Centers for Disease Control, Atlanta, (CDC). The patients were investigated immunologically with respect to their in vitro lymphocyte reactivity to various mitogens. The patients with AIDS and pre-AIDS belonged to the group of 8 patients with low response to mitogens. Blood helper T cell percentages and serum beta 2-microglobulin concentrations correlated with the PHA reactivity. Three patients, with the diagnoses AIDS, pre-AIDS and PGL respectively, had clinical signs of oral candidiasis with rich growth of Candida albicans in culture. These were all low responders to mitogen stimulation. Six cases of tinea pedis were diagnosed and seemed to be distributed among the patients irrespectively of the severity of their immunological disorders.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Further studies on the influence of interferon on pokeweed mitogen induced Ig-synthesis in vitro.

Preincubation with pure interferon beta, but not partially purified interferon alpha, increased immunoglobulin production from non-fractionated peripheral blood mononuclear cells stimulated by pokeweed mitogen. Preincubation of B lymphocytes, but not T lymphocytes or monocytes, with pure interferon beta also increased immunoglobulin synthesis. It is concluded that interferon has a direct effect on B lymphocytes in enhancing immunoglobulin production.

B-Lymphocytes↗
PubMed1985

Long-term effects on the immune system following local irradiation for breast cancer. Pokeweed mitogen induced immunoglobulin secretion by blood lymphocytes and serum immunoglobulin levels.

Previous studies have shown that the PWM driven immunoglobulin (Ig) secretion by blood lymphocytes in vitro is reduced shortly after local radiation therapy for breast cancer. In this investigation we have examined the long-term effects of radiation therapy (45 Gy) on this lymphocyte function. A total of 111 disease-free patients treated for operable breast cancer 5-6 and 10-11 years earlier were examined. The Ig classes studied were IgM, IgA and IgG. All patients belonged to a clinical trial where the effect of pre- or post-operative local radiation therapy was evaluated against surgery only. Significant reductions of the amount of spontaneously released IgM in vitro were observed among irradiated patients as compared to the unirradiated 5-6 and 10-11 years after treatment. Such a difference was not observed for IgA and IgG. The PWM induced Ig secretions did not differ significantly between the three patient groups. The long standing reduction of the spontaneous release of IgM by blood lymphocytes in vitro probably lacks clinical significance since the serum levels of this Ig class, as well as IgA and IgG, were similar in irradiated and unirradiated patients.

Aged↗
PubMed1984

Treatment of patients with disseminated colorectal cancer with recombinant human alpha 2-interferon. Studies on the immune system.

The influence of recombinant human alpha 2-interferon (alpha 2-IFN) therapy on various aspects of the immune system was studied in 18 patients with disseminated colorectal cancer. The IFN was given as continuous (20 X 10(6) units/m2 three times weekly) or intermittent (50 X 10(6) units/m2 daily for 5 consecutive days every 4 weeks) treatment. Natural killer (NK) cell activity increased during continuous treatment and in the patients receiving repeated cycles of IFN, all cycles seemed to be associated with an elevation of NK activity. Prior to treatment, addition of IFN to the assay in vitro induced an enhancement of NK activity, whereas during treatment, IFN in vitro did not cause any further enhancement of NK activity. The proportions of total T cells, suppressor T cells and helper T cells, as measured by Leu 1, Leu 2a and Leu 3a monoclonal antibodies, were not altered to any major extent during treatment. This was found to be the case also for the number of cells detected by monoclonal antibodies against NK cells (Leu 7). The phagocytic activity of granulocytes was not altered during IFN therapy, whereas the capacity of these cells to reduce nitroblue tetrazolium (NBT) increased after the first injection of IFN. The in vivo influence of high doses of highly purified recombinant alpha 2-IFN on NK cells and granulocytes seems to be similar to that of partially purified natural IFN-alpha.

Adenocarcinoma↗
PubMed1984

Changes of blood T cell subsets in patients receiving postoperative adjuvant chemotherapy for breast cancer.

The number of T helper (Th) and T suppressor (Ts) cells, as defined by monoclonal antibodies, of the blood lymphocyte population was examined in breast cancer patients receiving postoperative cyclic therapy with cyclophosphamide, methotrexate and 5-fluorouracil. The total number of lymphocytes was reduced to approximately 50% at the end of the 17-month period of chemotherapy. Identification of Th and Ts subsets with the aid of Leu-3a and Leu-2a antibodies revealed that the former was reduced to a higher relative extent than the latter, thus reducing the Th/Ts ratio highly significantly during the entire treatment period. A reduced ratio was also observed in a group of patients having completed their treatment 2-3 yr earlier.

Adult↗
PubMed1984

Possible role of prostaglandin producing monocytes in the depression of mitogenic responses of blood lymphocytes following radiation therapy.

Previous studies have shown that the depression of mitogenic responses of cultured blood lymphocytes following radiation therapy can largely be explained by immunosuppressive cells. In this investigation we have shown that the addition of silica, a monocyte toxic agent, to the cultures enhance the PHA- and PPD-responses of the cells at completion of irradiation. Such an effect, however, was not noted before radiation treatment was started. Similar results were obtained by adding indomethacin, an inhibitor of prostaglandin synthesis, to the cultures. The results thus indicate that immunosuppressive monocytes which mediate their activity by prostaglandins are involved in the reductions of mitogen responses of blood lymphocytes following irradiation.

Adult↗
PubMed1984

Cord blood T lymphocyte subpopulations in premature and full-term infants.

Cord blood lymphocyte preparations from premature and full-term infants were examined for T cell subsets using monoclonal antibodies. The number of T cells in relation to the total number of lymphocytes, the proportions of T helper (Th), and T suppressor (Ts) phenotypes, respectively, were the same in preterm infants of gestational age (GA) 26-36 weeks and term infants (GA 38-41) weeks). There was no correlation between GA and Th/Ts ratio. The relative number Ts was significantly lower in infants than in adult women.

Adult↗
PubMed1984

Antibody against Encephalitozoon cuniculi in Swedish homosexual men.

Sera of 30 Swedish homosexual men belonging to the group at risk for the acquired immunodeficiency syndrome (AIDS) were examined for antibodies against various opportunistic parasites. Antibodies to Encephalitozoon cuniculi were found in 33%, to Pneumocystis carinii in 43%, and to Toxoplasma gondii in 37%. The results indicate that E. cuniculi might be transmitted among homosexual men.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Relation between skin anergy, lymphadenopathy and T-cell subsets in Swedish homosexual men.

Reversed T-helper/T-suppressor ratios were found in 20/43 symptomatic homosexual men. A significant lower number of T-helper cells was found in patients with skin anergy. No differences were noticed in total lymphocytes or in any of the other T-cell subsets, when subjects with and without skin anergy or lymphadenopathy were examined.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Prognostic value of various immunological tests in breast cancer patients treated with adjuvant postoperative chemotherapy.

Eighty-three patients, operated for carcinoma of the breast, received adjuvant therapy with chlorambucil, methotrexate and 5-fluorouracil or cyclophosphamide, methotrexate and 5-flourouracil. This group was subjected to a study exploring prognostic value, as defined by disease-free survival, of some immune variables. These included numbers of blood lymphocytes expressing membrane receptors for sheep erythrocytes (mainly T-cells), receptors for C'3 (mainly B-cells) and proliferative responses of the cells to phytohemagglutinin, purified protein derivative of tuberculin and in a mixed lymphocyte culture. Follow-up time was 30-71 months after start of adjuvant therapy. None of these variables showed any significant relation to prognosis in the present patient material. In addition, there was no detectable relation between numbers of eosinophils in the blood and disease-free survival. The well-known importance of tumor size and/or involvement of axillary nodes was, however, confirmed.

Adult↗
PubMed1983

Changes of blood T cell subsets following radiation therapy for breast cancer.

The changes of the size of various T cell subsets in the blood, as defined by monoclonal antibodies and Fc-receptors for IgG and IgM, were examined in 11 women after postoperative radiation therapy (45 Gy) for breast cancer. All subsets of T cells were significantly reduced at completion of irradiation. The most extensive depletion was noted in a subset with receptors for IgG, which may exert suppression. Approximately 1 year later this subset had recovered significantly in parallel with another subset, also rich in suppressor T cells, which was detected by monoclonal antibodies. On the contrary, T cell subsets rich in cells with helper activity did not exhibit any significant recovery.

Adult↗
PubMed1983

Osteomyelitis caused by Mycobacterium avium.

Osteomyelitis due to M. avium is extremely rare and frequently fatal. The successful cure of an 11-year-old patient with multiple mycobacterial lesions in the pelvis and right humerus is reported. Although the mycobacteria were in vitro resistant to most antituberculous drugs a five-drug regimen was given over a total of 2 1/2 years. The accumulated streptomycin dose was 160 g but no adverse effects were noted. Streptomycin therapy was judged of major importance for the favourable outcome.

Child↗
PubMed1983

T lymphocyte subpopulations in alopecia areata and psoriasis: identification with monoclonal antibodies and Fc receptors.

A comparison of T lymphocyte subpopulations as defined by Fc receptors and monoclonal antibodies was investigated in 9 patients with alopecia areata and alopecia universalis (AA and AU) and in 6 patients with psoriasis. It was shown that there was higher proportion of T lymphocytes with Fc receptors for IgG (Tg cells) in patients with alopecia (AA and AU) and psoriasis. The proportions of total T lymphocytes (Tt), T lymphocytes with Fc receptors for IgM, T suppressor/cytotoxic cells (Leu2A), T helper/inducer (Leu3A) as defined by monoclonal antibodies were within normal range as compared to the normal donors. The possible reason of the dissociation between Tg and T suppressor (Leu2A) cells could be that these cells belong to different subpopulations.

Adult↗