Possible additions to the spectrum of core-excited neutral sodium.
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Journal Article↗
Biomedical subjects
B Petterson
Publications and source records attributed to B Petterson.
Liver and skeletal muscle metabolism, extracellular K+ concentrations, and survival in spontaneously hypertensive rats following acute blood loss.
The metabolic responses of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) to acute blood loss (30% of the calculated blood volume) have been studied. The initial mean arterial pressure (MAP) was 179 mmHg in SHR and 105 mmHg in WKY. After bleeding, MAP decreased to about 50 mmHg in both groups. SHR failed to increase MAP in the posthemorrhagic period, while in WKY a level of 65-70 mmHg was reached. Metabolic changes in liver and skeletal muscle, indicative of tissue hypoxia, occurred earlier and were more pronounced in SHR than in WKY. In SHR, the ATP content of the liver was almost depleted within 1 h, while during the same time period only a moderate reduction was seen in WKY. Extracellular K+ concentration in sketetal muscle increased more rapidly in SHR than in WKY, but a similar relationship between lactate content and extracellular K+ concentration was found in both groups. The mean posthemorrhagic survival time was only 47 min for SHR, as compared to 193 min for WKY. The present results indicate that a blood loss is more detrimental for hypertensive than normotensive rats.
Acute Disease↗
IDEA (Intellectual Disability Exploring Answers): a population-based database for intellectual disability in Western Australia.
Despite the demands it places on individuals, families and the community, intellectual disability (ID) is a neglected area of public health. Accurate estimates of prevalence are sparse and range from 0.5 to 3.0%. The cause of the condition is unknown in at least 50% of cases. This paper describes the Intellectual Disability Exploring Answers (IDEA) database set up in Western Australia to provide an infrastructure for research and to facilitate the planning of service provision for people with ID. Since 1953 a database for ID has been maintained in Western Australia, a state with a population of 1.95 million in an area of 2.52 million km2. The current IDEA database aims to obtain ongoing population-based ascertainment of ID from providers of clinical and educational services, with the potential for linkage to a network of other state databases. The average prevalence of ID for children born in Western Australia over the years 1983-1996 was 15.2 per 1000 live births, with 50% ascertained only through the education system. During this time period 60% of cases were male. Of children with an ID born in Western Australia in 1980-1999 and surviving to 1 year, 30.1% had a birth defect, and the prevalence ratio of birth defects in this group compared to the population with no birth defects was 6.5 (CI 6.3-6.8).
Adolescent↗