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Biomedical subjects

B Pflug

Publications and source records attributed to B Pflug.

68 records · Page 4Linked to original sources
PubMed1976

The effect of sleep deprivation on depressed patients.

In this paper an account is given of the effect of single-night sleep deprivation (SD) therapy in 124 depressive patients of different diagnostic groups. Phasic depressives showed a marked improvement after treatment by sleep deprivation. Because these improvements were often of short duration, we repeated the treatments and combined them with thymoleptic drugs. In the group of neurotic depressives the therapeutic effect of sleep deprivation varied; on the whole, however, the improvement was less marked. It is pointed out that the vital symptoms and "critical time" are of importance. Sleep deprivation can be explained as a resynchronization of disturbed circadian rhythms brought about by interrupting these rhythms.

Adjustment Disorders↗
PubMed1976

Depression and daily temperature. A long-term study.

In a long-term observation of a manic-depressive female patient, three depressive episodes and two intervals without complaints were studied. During this period, the oral temperature was measured every 3 h. The temperature values were compared with a self-rating scale of the patient. The oral temperature showed a different pattern on the depressive days as compared with the interval days. The average temperature values were higher on depressive days. During the depression, changes were found in the daily temperature rhythm which resulted in a temperature maximum earlier in the day. The changes can be explained as indicating a desynchronization phenomenon of the circadian rhythms.

Adult↗
PubMed1976

[Methodological problems of the clinical research on rhythms in depressive patients (author's transl)].

The working hypothesis is discussed that desynchronized rhythmic functions are at the root of endogenous depression. Methods and problems of the clinical research on rhythms in depressives are concerned with the assessment of data, experimental conditions, technical procedures and the personality of the depressive patient in his predicament. Investigations of groups of patients are considered critically, the necessity of intraindividual long-term studies is emphasized.

Body Temperature↗
PubMed1976

[Thin-layer chromatographic determination of plasma levels of tricyclic psychopharmacological drugs: first results on their relationship to the clinical activity of neuroleptics (author's transl)].

Plasma levels of perazine, clozapine, amitriptyline and imipramine and of their demethylated metabolites can be measured in patients receiving therapeutic doses by UV reflectance photometry of thin-layer chromatograms of plasma extracts, Large inter-individual variations were observed in unselected psychiatric patients treated with comparable doses. An investigation into the relationship between plasma levels and therapeutc effect in acutely schizophrenic patients was carried out for perazine and clozapine. With perazine, a group of patients exhibiting an unsatisfactory response had a tendency to show lower plasma levels than a group with a good response; in some patients of the former group, increase of the dose with concomitant increase of the plasma level led to a satisfactory therapeutic effect. In patients treated with clozapine, such a relationship could not be demonstrated.

Antidepressive Agents, Tricyclic↗
PubMedDate not supplied

Influence of lithium ions on human circadian rhythms.

Lithium carbonate lengthens the circadian period of body temperature and sleep-wakefulness in humans under temporal isolation (arctic conditions in Svalbard, 79 degrees N) in two out of four groups.

Adult↗
PubMedDate not supplied

[Studies on sleep and wakefulness in very old subjects].

Disturbances of nocturnal sleep and the frequency of prescription of hypnotic drugs are more frequently found in elderly people. The majority of studies on sleep in the elderly have focussed on subjects between 60 and 80 years. Even though the number of people aged 80 to 90 years has clearly increased during recent years, still only rare data are available concerning sleep in this group. The present study investigated sleep, wakefulness, and, in addition, the cognitive functions in a group of seniors not suffering from sleep disturbances, aged 80 to 90 years. The evolution of sleep and sex differences of sleep variables dependent on age with respect to the findings in an 85-year-old woman and an 82-year-old man are discussed. Polysomnographic parameters and subjective estimation of sleep quality were compared. Possible correlations of REM-sleep and the results of the Nürnberger-test-battery were evaluated. Finally, subjective estimation of daytime sleepiness with reference to sleep variables was evaluated.

Aged↗
PubMedDate not supplied

[A gerontopsychological pilot study on the sleep of the very elderly--initial experiences with the Nürnberg Gerontopsychologic Inventory].

In an ongoing study of sleep in aged seniors the relationship between physiological, pathophysiological changes of sleep parameters and cognitive function was studied. It will be argued that the Nuremberg gerontopsychological inventory is superior to commonly used psychometric test-batteries to assess cognitive function in the aged. Preliminary results on the application of the Nuremberg gerontopsychological inventory will be presented, which were achieved in 10, non-demented, independently living subjects aged 80 to 85 years. The relationship between subjective complaints on aging, everyday activities and psychometric assessed performance was analyzed in detail.

Activities of Daily Living↗
PubMedDate not supplied

[Psychological and physical compromises in patients with organic cerebral psychosyndrome--analysis of treatment success].

The extent of psychic and physical disturbances of patients admitted to the Center of Psychiatry in Frankfurt/M. because of organic psychosyndromes in the year 1988 was analysed. Especially the results of the hospital treatment and the proceeding mode of caretaking were examined. Usually an unspecific state of confusion was the main reason for admittance of most of the patients (n = 59). The majority of the patients suffered from a mid-ranged to marked state of dementia. The results of the treatment for these patients was highly significantly worse compared to patients admitted with a psychosis or a depressive syndrome. A non-significant statistical correlation was found for the results of the medical treatment and medical diseases. Concerning the treatment with psychic drugs a pragmatistic order was used. Analysing the results no advantage of a treatment with up to 4 different drugs compared to a monotherapy could be found. Patients who were not treated with psychic active substances tended to have a poorer outcome. At the end of the stay in the hospital 25.4% of patients were classified with a good outcome after treatment, 49.2% had a slight degree of recovery.

Activities of Daily Living↗