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Biomedical subjects

B Phelps-Sandall

Publications and source records attributed to B Phelps-Sandall.

3 recordsLinked to original sources
PubMed1989

A prenatal diagnostic center's first-year experience with the California alpha-Fetoprotein Screening Program.

The University of California Davis Medical Center has offered secondary and tertiary care to pregnant patients with abnormal maternal serum alpha-fetoprotein levels since the start of the California alpha-Fetoprotein Screening Program in April 1986. In our first year of involvement with this method of prenatal screening, 452 patients were referred to our center for further evaluation and follow-up of either high or low maternal serum alpha-fetoprotein levels, as determined by the standard multiple of the median adjusted for maternal weight, race, and presence of insulin-dependent diabetes mellitus. This article presents the first-year results of our clinical experience. Information is presented concerning medical complications, screening and diagnostic test results and their confirmation, clinical procedures performed, and postpartum follow-up reports. Findings of pregnancy outcomes associated with low and high alpha-fetoprotein levels are presented and discussed.

Adult↗
PubMed1986

Analysis of the significance of discolored amniotic fluid detected at midtrimester amniocentesis.

In 110 midtrimester amniocenteses of the 3349 procedures done at the University of California, Davis, Medical Center between 1979 and 1984, the fluid obtained was noted to be discolored. The significance of this finding was evaluated with review of pregnancy history and outcome and by using biochemical techniques. A significant increase in miscarriage was seen in the pregnancies where discolored fluid was obtained (9%), in comparison with the entire group of pregnancies in which amniocentesis was done at the same institution over the same period (1.6%). This increase was most marked in the pregnancies in which, in addition to discolored fluid, there was a prior history of pregnancy bleeding. Thirty-four discolored fluid samples and 18 clear fluid samples were studied with spectrophotometry, electrophoresis, isoelectric focusing, and chromatography. These studies indicate that in most cases the discoloring pigment is blood rather than fetal bowel contents, as had been suggested by others.

Abortion, Spontaneous↗