Biomedical subjects
Publications and source records attributed to B Pirotte.
A 36 year old woman who ruptured a basilar artery aneurysm at 38 weeks gestation in her second pregnancy was managed successfully by endovascular embolisation 36 hours after an emergency Caesarean section. The timing of treatment along with the obstetric, neurosurgical and anaesthetic aspects of this complex problem are discussed along with a review of the current literature on the subject.
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Explore the source record for details and available documents.
Potassium channels (K+ channels) constitute the most diverse group of ionic channels. One of them, the ATP-sensitive K+ channel (KATP channel), was identified in numerous tissues (smooth muscle, pancreatic B-cells, central nervous system,...). This channel is of particular interest for us since we have developed various pharmacological models for the study of new potassium channel openers. Among those, diazoxide (a benzothiadiazine dioxide) is an interesting reference compound since its biological activity was observed with comparable intensity on the vascular tissue (smooth muscle) as well as on the pancreatic tissue (endocrine tissue). One of our aims was the preparation of original pyridinic analogues of diazoxide (pyridothiadiazinedioxides) and their evaluation as potassium channel openers in order to show a tissue selectivity different from that of diazoxide. Indeed, therapeutic perspectives of potassium channel openers will depend upon the discovery of new classes of compounds exhibiting an effective tissue selectivity.
Pharmacomodulation of torasemide, a diuretic sulfonylurea, led to the discovery of two novel diuretics, a sulfonylthiourea (BM 20) and a sulfonylcyanoguanidine (BM 106). BM 27, a lipophilic sulfonylurea, exhibited neuroprotective properties associated to an anticonvulsant activity. As BM 27, two lipophilic sulfonythioureas (BM 11 and BM 34) revealed an anticonvulsant profile similar to that of phenytoin. Finally the synthesis of torasemide derivatives led to the development of a sulfonylcyanoguanidine (BM 144) with a thromboxane A2 antagonist potency.