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Biomedical subjects

B Power

Publications and source records attributed to B Power.

25 records · Page 2Linked to original sources
PubMed1986

Ultrastructural features of atrial peptide secretion.

The ultrastructural bases of exocytotic extrusion of atrial peptides were reexamined in electron micrographs of thin-sectioned or freeze-fractured mouse atria. Exocytotic extrusion was demonstrated in both thin-sectioned and freeze-fractured atrial myocytes. Ultrastructural evidence suggested that the necks of plasmalemmal caveolae may constitute preformed pathways for extrusion of secretion from granules fusing with caveolae. Multiple subsarcolemmal foci with peripheral Golgi cisterns and accumulations of granules, indicating peripheral processing of secretory proteins, were striking features of mouse and rat atria, and were present but rare in sheep and dog atria. Conspicuous focal ellipsoidal deposits, a new structure, approximately 1.6-4.6 micron long and approximately 0.8-1.8 micron wide, consisting of amorphous cytoplasmic material that is penetrated peripherally by tubules connecting with secretion-containing "multivesicular bodies," were present in some mouse atrial myocytes, but were absent in myocytes of mouse ventricle and rat, dog, and sheep atria.

Animals↗
PubMed1983

Utilization of psychotropic drugs in Saskatchewan: 1977-1980.

Psychotropic drug use in Saskatchewan during 1977, 1978, 1979 and 1980 was determined. Approximately one in five prescriptions dispensed was for a psychotropic. About 20% of the population received psychotropic drugs in each year but use has declined slightly, especially that of tranquilizers. Psychotropic use increased with the patient's age and nearly two-thirds were women. Considerable caution should be exercised in making comparisons with other drug utilization studies. There may be substantial differences in the drugs selected for study, the categorization of these drugs, and the methodology used to analyze drug use. Also, most studies are based on data that is from a decade old or older. Moreover, most if not all other studies on drug use are based on sample surveys (from different sampling universes), whereas the present study is based on the entire population. Nevertheless, some generalizations may be valid. Since non-formulary drugs are excluded, the findings should be regarded as conservative. Examples of non-formulary drugs considered to be psychotropic include antispasmodic/tranquilizer/sedative combinations (example: Librax, Donnatal), combination hypnotics (example: Tuinal, Mandrax), and some combination analgesics (example: propoxyphene compounds, pentazocine compound, oxycodone compound).

Adolescent↗
PubMed1971

Sterological measurements of cardiac ultrastructures implicated in excitation-contraction coupling.

Electron micrographs of osmium-fixed left ventricles from 200-g female rats were analyzed by stereological techniques. By the use of equations developed by H. Sitte it was possible to determine volume fractions of organelles and absolute membrane areas per unit cell volume for cellular membrane systems implicated in excitation-contraction coupling. The fractions of cell volume were: mitochondria 0.34, myofibrils 0.481, T-system 0.012, total sarcotubules 0.035, other 0.13. The membrane areas per unit cell volume (mum(2)/mum(3)) were: external sarcolemma 0.27, external sarcolemma + T-system 0.34, total sarcotubules 1.3. Diads made up 0.08 of sarcotubular volume and 0.12 of sarcotubular membrane area. 0.14 of the external sarcolemmal membrane area was involved in diadic complexes with underlying subsarcolemmal cisterns.

Animals↗