Biomedical subjects
B Prinz
Publications and source records attributed to B Prinz.
Improvement of cutaneous manifestations in POEMS syndrome after UVA1 phototherapy.
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Long-term application of extracorporeal photochemotherapy in severe atopic dermatitis.
BACKGROUND: Extracorporeal photochemotherapy (ECP) using UVA irradiation of enriched leukocytes in the presence of methoxsalen as a photoactivatable substrate has been employed for the treatment of several immunologically mediated disorders. OBJECTIVE: Our purpose was to determine the efficacy and safety of long-term ECP in the treatment of severe atopic dermatitis. METHODS: Fourteen patients with severe recalcitrant atopic dermatitis were treated with ECP in an open clinical trial at 2-week intervals. Disease activity was scored before each ECP cycle by means of a standardized protocol. RESULTS: A complete clinical remission was achieved in 4 patients (29%). Five patients (36%) experienced a substantial response with reduction of skin inflammation by at least 75%, whereas in one patient (7%) disease activity was reduced by more than 50%. Four patients were withdrawn from the study for unresponsiveness. No clinical signs of immunosuppression or other severe adverse events became evident. CONCLUSION: Long-term ECP may have significant beneficial effects on the course of atopic dermatitis and should therefore be considered as a treatment modality for patients suffering from severe and otherwise refractory atopic skin disease.
Feasibility of dose-intensified paclitaxel after chemotherapy-induced renal insufficiency in a patient with renal transplantation.
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Dose-intensified weekly paclitaxel induces multiple nail disorders.
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The growth of non-pyramidal neurons in the primary motor cortex of man: a Golgi study.
In Golgi-Cox-impregnated motor cortex (regio precentralis) of six children (36 weeks of gestation to 13 month after birth) four types of interneurons of laminae II-VI have been investigated qualitatively and quantitatively and finally, compared with interneurons of a child (3 month of age) with Down's Syndrome. All cell measurements have been made by using a computerized digital morphometric system. In order to study the developmental stage of interneurons in our cases we statistically compared analogue neuron types in the brains. As parameters for characterizing non-pyramidal neurons served the pattern of dendritic branching, dendritic length for all dendritic orders within single dendritic fields, and of the whole neuron. The quantitative morphological study of dendritic arborizations revealed that bitufted and large multipolar interneurons had significantly more branching material in the postnatal brains than their prenatal counterparts. These differences were due to the increase of both length and number of branches during perinatal period. Such constant increment in dendritic span and branching provides larger receptive areas and that should improve the development of connections in functional intracortical columns. The quantitative parameter area of dendritic fields and number of branching points of the brain with Down's syndrome revealed in comparison with normal brain of the same age differences such as lower dendritic areas and a higher amount of branching points.
Extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma--the Düsseldorf and Munich experience.
Extracorporeal photopheresis (ECP) using UVA irradiation of enriched lymphocytes in the presence of 8-methoxypsoralen as a photoactivatable substrate was originally introduced as a therapeutic regimen for cutaneous T-cell lymphoma (CTCL). Whereas ECP has previously been reported to be useful primarily for erythrodermic lymphoma, our purpose was to obtain data on safety and efficacy of ECP in patients suffering from different stages of CTCL. We report on 17 patients, 3 with erythroderma and 14 with plaque or tumor stages. In contrast to other studies our patients were treated predominantly with ECP alone; only a few patients received concomitant therapy. These data have not been published previously, except for preliminary data on four patients. Of the 17 patients, 12 (70%) responded to ECP. In seven patients at least 50% of skin lesions disappeared (defined as partial response) and in five patients at least 25% of skin lesions disappeared (defined as minor response). In two patients the disease remained stable and in three patients the disease progressed under the ECP treatment. No complete remission was observed. Partial responses were achieved not only in patients with early CTCL (stage Ib) but also in those with far progressed tumours (stage IVa). After treatment for 6 months partial responders showed an increase in the number of NK cells in their peripheral blood (P < 0.01). We cannot confirm a relationship between this treatment and CD8 cell counts, as reported by others. Overall, our results indicate that ECP is a safe and effective regimen for the treatment of all stages of CTCL.
Treatment of severe atopic dermatitis with extracorporeal photopheresis.
Extracorporeal photopheresis using UVA irradiation of enriched lymphocytes in the presence of 8-methoxypsoralen (8-MOP) as a photoactivatable substrate has been employed for the treatment of several immunologically mediated disorders. We report on the first three patients subjected to extracorporeal photopheresis for severe atopic dermatitis. All patients had a lifelong history of atopic skin inflammation, and their disease had finally become resistant to well-established therapeutic regimes. Extracorporeal photopheresis resulted in a marked clinical improvement in the skin lesions of all patients. The decrease in cutaneous inflammatory activity became evident by the end of the second photopheresis cycle. In two patients skin lesions had virtually disappeared after the fifth treatment cycle, while in the third patient a lasting and substantial improvement in pruritus and erythema was achieved. Clinical remission was stable under maintenance therapy with prolonged intervals between photopheresis sessions. Therapeutic efficacy was reflected by a marked reduction in IgE serum levels in all three patients, while serum concentration of IgG, IgM and IgA as well as the profile of circulating lymphocytes remained essentially unchanged. No clinical signs of immunosuppression or other severe adverse events became evident. Collectively, our preliminary results indicate that extracorporeal photopheresis may interfere with the pathomechanisms leading to atopic dermatitis and therefore should be considered as a treatment modality for severe forms of this recalcitrant disorder.
[Extracorporeal photopheresis].
Extracorporeal photopheresis is a new therapeutic approach developed by Edelson et al.; it is conceptually designed for the management of diseases mediated by malignant lymphocyte pathology, such as cutaneous T-cell-lymphoma (CTCL), and other disorders mediated by aberrant lymphocyte function, e.g. autoimmune diseases. The treatment is described in this paper, and theories on the mechanisms of action are discussed. In addition, the indications for treatment with extracorporeal photopheresis are discussed.
[Use of the Steinbuch learn matrix for the formation of a regression model with binary variables].
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[Development-neurological examinations in the infant age. New concept in clinical and general practice].
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The application of Steinbuch's "Lernmatrix" as a new mathematical approach in the assessment of air pollution effects.
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[D-penicillamine slowing down the spontaneous regression of carbon tetrachloride cirrhosis].
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Letter: Air lead and blood lead levels in children.
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[The importance of lead pollution for pregnant women and the newborn in the Ruhr area. II. Communication (author's transl)].
Systematic measurements of blood lead levels in 315 mature and immature neonates and 198 mothers show that at least 40% of statistical variance in blood lead levels depends on lead immission at the mother's place of residence. Almost identical blood lead levels are found in identical and non-identical twins. These investigations demonstrate the value of a biological lead monitoring system. On this basis blood lead levels in areas not covered by the present study can be prognosticated.
[Significance of lead immission for pregnant women and neonates in the Ruhr area].
Systematic measurements of blood lead levels in samples from 176 mature and premature neonates and 59 mothers in the western Ruhr-Rhine area demonstrated that at least 30% of statistical variance in blood lead levels depended on lead immission at the mother's place of residence. The close correlation between neonatal and maternal blood lead levels was confirmed. Identical and non-identical twins had almost the same blood lead levels. Using a biological system for determining lead immission, blood lead levels in areas not covered by the present study can be prognosticated.