B Projesz | PubMed Health

PubMed1997

Is working memory intact in alcoholics? An ERP study.

Few investigators have applied the working memory theory to studies on abstinent chronic alcoholics, though it has been reported that the deficits in short-term memory appear to be specific to visuo-spatial and problem-solving tasks. In the present study, we recorded ERPs from 40 male control subjects and 78 alcoholics performing a modified delayed matching to sample task. To minimize the possible confound of retinotopic projections for the matching stimuli, in contrast to the non-matching stimuli, we employed a unique set of stimuli in our delayed matching to sample task. Our results indicate that an ERP component, occurring at approximately 250 ms post-stimulus, may be a reflection of the ERP mnemonic effect for working memory. This component distinguishes the two groups at the right occipitotemporal region, providing evidence of right hemisphere dysfunction in alcoholics. Thus, the current experiment may show electrophysiological evidence of working memory deficits in alcoholics.

Adult↗

PubMedDate not supplied

Temporal recovery of auditory evoked potentials in individuals at risk for alcoholism.

The present investigation examined auditory evoked potential (AEP) recovery functions in both high-risk (HR, N = 23, mean = 22.3) and low-risk (LR, N = 27, mean = 23.0) males. A series of binaural auditory stimuli, with randomly interposed interstimulus intervals (ISIs) of 0.5, 1.0, and 10.0 s, were used to elicit the N1 and P2 components of the AEP. Scalp potentials were recorded from the 19 electrodes comprising the 10/20 International System. For purposes of statistical analysis, five electrode groups were created: frontal (F), central (C), parietal (P), occipital (O), and temporal (T). The results of within-group MANOVA demonstrated that in both LR and HR individuals, increases in the ISI produced significant N1 and P2 amplitude increases without significant latency differences. These amplitude increases occurred primarily in the F and C regions. However, the results of between-group MANOVA indicated that there were no differences in the recovery functions of the two risk groups. Our results indicate that in both LR and HR individuals, recovery functions are responsive to changes in increasing ISI. However, they did not effectively discriminate between risk groups. It is speculated that risk group differences may be apparent with the use of an ethanol challenge.

Adolescent↗