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Biomedical subjects

B R Clower

Publications and source records attributed to B R Clower.

At least 37 records · Page 2Linked to original sources
PubMed1985

Heparin reduces proliferative angiopathy following subarachnoid hemorrhage in cats.

Subarachnoid hemorrhage (SAH) was produced in cats by transorbital rupture of the right middle cerebral artery (MCA). In untreated cats, widespread proliferative angiopathy occurred in both MCA's by 16 days after SAH. In cats that received systemic heparin, the pathological events following SAH were clearly reduced in the ruptured artery, and were not present in the contralateral left MCA. Platelets are known to adhere to the subintimal surface of cerebral arteries after SAH. The authors suggest that platelet-derived growth factor released from the intimal platelet carpet following SAH may be the stimulus for the development of proliferative angiopathy, and that this platelet factor is inhibited by heparin.

Animals↗
PubMed1984

Intracranial vessels lack vasa vasorum.

A micro-corrosion technique was used to demonstrate an extensive vasa vasorum network in extracranial vessels but did not reveal this system in intracranial vessels of comparable size in three species of animals. The absence of a vasa vasorum network in cerebral vessels may result in a higher level of susceptibility to periarterial abnormalities, such as cerebral vasospasm secondary to subarachnoid hemorrhage.

Animals↗
PubMed1972

Light and electron microscopy of diet-induced atrial thrombosis in Swiss mice. II. Recovery on return to a balanced diet.

Diet-induced ultrastructural changes that occur in the atrial wall prior to thrombus formation are atrial subendothelial edema, endothelial vacuoles, damaged basement membrane and villous projections from endothelial (luminal surface) cells. Upon the return to a normal diet for 1-4 weeks, atrial edema is completely reversible, while the other ultrastructural alterations show minor or no signs of being repaired.

Animals↗