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Biomedical subjects

B R Farrow

Publications and source records attributed to B R Farrow.

At least 37 records · Page 2Linked to original sources
PubMed1984

Autoimmunity in spontaneous myasthenia gravis in dogs.

Spontaneous canine myasthenia gravis (MG) mimics the human disease in almost every respect. Both dogs reported here exhibited the autoantibodies characteristic of MG, i.e., anti-acetylcholine receptor (anti-AChR) and antistriational (AStr). Fluctuations in the anti-AChR titer during spontaneous remission and recurrence of MG in one dog provide support for the concept of a symptomatic threshold titer above which anti-AChR must rise before disease signs develop. The increase in the anti-AChR titer and recurrence of disease signs followed vaccination and an infection. Interestingly AStr also reappeared in this dog and serum IgG concentration increased. AStr in the second dog was associated with the presence of a thymoma and had a staining pattern characteristic of human MG.

Animals↗
PubMed1984

Canine fucosidosis: a biochemical and genetic investigation.

Plasma and leucocytes from six springer spaniels with clinical signs of fucosidosis had low activities of alpha-L-fucosidase. Fucosidase activities in plasma and leucocytes from parents of springers with fucosidosis were approximately half those in non-springer dogs. Examination of pedigree information in relation to classifications based upon plasma and leucocyte assays provided convincing evidence that fucosidosis is inherited in an autosomal recessive manner and that it is possible to detect heterozygotes using plasma and leucocyte assays.

Animals↗
PubMed1983

Sporozoa in dogs and cats.

Faecal samples from 110 dogs and 71 cats were examined for sporozoan parasites by flotation. Isospora spp were present in 5.5% dogs and 4.2% cats; Sarcocystis spp in 20.9% dogs and 1.4% cats. 74.5% dogs and 77.5% cats were fed raw meat from various sources; beef was fed most often. Animals fed raw meat were more frequently infected with protozoa. No Toxoplasma oocysts were found. The results are compared with those from other surveys in Australia and New Zealand.

Animals↗
PubMed1983

Type C botulism in young dogs.

A diffuse lower motor neurone paralysis developed in a 6-month-old male Australian cattle dog pup 4 days after it had eaten the carcase of a rotting duck in Centennial Park, Sydney. Two other dogs which ate smaller portions of the same carcase were less severely affected. Clostridium botulinum type C was isolated from and C. botulinum type C toxin was detected in faeces from the severely affected dog. The serum contained 25 LD50 of toxin/ml. The high C. botulinum count and toxin level in the faeces declined progressively during the ensuing weeks, but 114 days after ingesting the carcase C. botulinum type C was still present in faeces and a low toxin titre persisted. Soil, mud and water samples in the area of the duck ponds in the park contained C. botulinum type C spores. Spores and high toxin titres were also found in the intestine of the carcases of 2 birds in the area.

Animals↗
PubMed1979

Canine Gaucher disease--the enzymic defect.

beta-Glucosidase activity was investigated in tissues from a case of canine Gaucher disease and from a normal dog. In the latter, enzyme activity showed two pH optima at pH 4-0-4-25 and pH 5-0-5-5. In Gaucher disease tissues, negligible activity could be measured at the mouse acidic pH.

Animals↗