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Biomedical subjects

B R Patel

Publications and source records attributed to B R Patel.

At least 37 records · Page 2Linked to original sources
PubMed1985

Proximal gastric vagotomy and mucosal antrectomy: a comparative physiologic examination.

Proximal gastric vagotomy-mucosal antrectomy (PGV-MA) was devised in an attempt to reduce the cephalic and hormonal phases of acid secretion without disturbing gastric emptying. The current study determines the effects of proximal gastric vagotomy (PGV), or PGV-MA on acid secretion, gastrin, and gastric emptying. Twelve dogs underwent measurement of gastric emptying, fasting and postcibal acid production, and fasting and postprandial gastrin levels. The animals then underwent either PGV or PGV-MA and the studies were repeated. PGV markedly decreased basal acid (P less than 0.001); however, there was still a large postprandial acid increase. In contrast, PGV-MA nearly abolished both fasting and postprandial acid secretion (difference from control and PGV significant at P less than 0.001). Gastric emptying was not significantly altered by either procedure. PGV was associated with increased fasting and postprandial gastrin levels, while PGV-MA produced lower gastrin levels at all intervals than either controls or PGV-MA. PGV-MA emulates the effects of truncal vagotomy and antrectomy on acid secretion, without affecting gastric emptying and deserves further investigation as a possible surgical alternative in the treatment of duodenal ulcer disease.

Animals↗
PubMed1985

Behçet's syndrome complicated by cutaneous leukocytoclastic vasculitis. Response to prednisone and chlorambucil.

Traditionally described as a triad consisting of recurrent aphthous stomatitis, genital ulcerations, and uveitis, Behçet's syndrome is now recognized as a multisystem disease with protean manifestations. We studied a patient with chronic recurrent migratory superficial thrombophlebitis and marked cutaneous hyperreactivity (pathergy) who developed leukocytoclastic vasculitis with recalcitrant leg ulcerations nine years after the onset of his illness. Although he was treated with topical and systemic antibiotics for presumed bacterial superinfection, cutaneous ulcerations continued to develop and enlarge; only after prednisone therapy was begun was there a dramatic response with complete resolution. Despite high-dose prednisone therapy, the pathergy test remained markedly positive; however, no new skin ulcerations appeared.

Adult↗
PubMed1985

The effect of fundoplication with or without proximal gastric vagotomy on gastric emptying and serum gastrin.

Jordan and Herrington have both advocated the addition of a proximal gastric vagotomy [PGV] to fundoplication to improve exposure and decrease the likelihood of vagal entrapment which might lead to delayed gastric emptying. This study documents the effect of fundoplication with or without PGV on gastric emptying and postprandial gastrin values. Twelve dogs had measurement of gastric emptying of an isotopically labeled solid meal. Plasma gastrin was also measured at 15-min intervals for 1 hr postprandially following a 60 g beef meal. Six of the animals then had a standard fundoplication with incorporation of vagi in the wrap; the other six underwent fundoplication combined with PGV, excluding the vagi. All studies were repeated after 8 weeks. Gastric emptying was unchanged by fundoplication alone. PGV resulted in a slight but significant slowing of gastric emptying (P = 0.04), values by paired t test. Fundoplication alone had no effect on serum gastrin levels, but there was a slight, statistically insignificant increase in serum gastrin when PGV was added (P greater than 0.1). This delay could aggravate pre-existing emptying problems in patients with esophagitis. These data do not support inclusion of proximal gastric vagotomy as a routine part of the fundoplication.

Animals↗
PubMed1983

Radionuclide bone scan as an aid in localizing lesions for bone biopsy.

Two cases are cited as examples of the usefulness of bone scan-guided bone biopsies, using a lead marker for lesion localization, especially when the lesions are otherwise difficult to localize. This technique is quite useful in evaluating new solitary bone lesions in patients with a known primary malignancy.

Adult↗
PubMed1983

Actinobacillus actinomycetemcomitans endocarditis in hypertrophic obstructive cardiomyopathy.

We report a case of bacterial endocarditis due to Actinobacillus actinomycetemcomitans in a man with hypertrophic obstructive cardiomyopathy complicated by a mycotic aneurysm and thrombosis of the right common iliac artery. The patient was successfully treated with a combination of ampicillin and gentamicin, but was left with residual mitral incompetence.

Actinobacillus Infections↗
PubMed1983

Delayed renal localization of Ga-67: concise communication.

Five hundred Ga-67 images, requested for detection or follow-up of inflammatory or neoplastic diseases, were reviewed to evaluate the incidence of delayed renal localization and the clinical significance of different degrees of uptake. Renal uptake in 48- or 72-hr images was graded as follows: 0 = background activity; 1+ = greater than background but less than spine; 2+ = close to spine but less than liver; 3+ = same as liver; 4+ = greater than liver. On the 500 images, 996 kidneys were evaluated and among them 600 (60%) had 0 uptake and 340 (34%) had 1+. These 940 kidneys were all considered to be normal. Fifty-six (6%) had 2+ or more uptake, with possible causes for uptake being: infection 27, drug-induced renal damage ten, urinary stasis or slow excretion seven, collagen vascular disease six, renal failure four, acute tubular necrosis one (ATN), and indeterminate one. Cases of renal infection or failure tended to show more or less 4+ uptake, while drug damage, ATN, or urinary stasis tended to have 2+ uptake.

Adolescent↗