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Biomedical subjects

B R Rund

Publications and source records attributed to B R Rund.

At least 37 records · Page 2Linked to original sources
PubMed1998

Covert visual attention in patients with early-onset schizophrenia.

The aim of the present study is to examine attentional costs (inhibition) in covert visual attention in a group of acutely ill adolescents with schizophrenia without long histories of neuroleptic treatment. Variations in reaction time were analyzed for possible age and sex differences. Adolescents with schizophrenia (n = 19) were compared to a group of ADHD subjects (n = 20) and a group of normally functioning adolescents (n = 30) on a measure of covert visual attention. The results support a hypothesis of abnormally rapid disengagement (reduced costs) in male adolescents with schizophrenia. Such an abnormality has also been found in adults with chronic schizophrenia. Whether this holds true for both sexes of adolescents with schizophrenia or is restricted to male subjects cannot be answered with certainty due to the small number of females with schizophrenia in our sample. Our findings indicate, however, that there are some general sex differences and some specific sex differences related to covert visual attention in adolescents with schizophrenia.

Adolescent↗
PubMed1998

"Full recovery" from schizophrenia in the long term: a ten-year follow-up of eight former schizophrenic patients.

The present study reports longitudinal data on individuals who ten years ago were fully recovered from a previously diagnosed schizophrenia. Seven out of ten subjects consented and were reexamined at the present follow-up, and data on an eighth subject was secured elsewhere. A semistructured interview was used to examine psychosocial functioning of the subjects in the follow-up period. Out of the six subjects with a confirmed diagnosis of schizophrenia, only three subjects were still fully recovered; one had a deteriorating course and two had a fluctuating course of illness. The results from the study indicate that recovery from schizophrenia may take the form of time-limited remissions for half of the reexamined subjects when strict criteria for full recovery are used. Protective factors such as willpower, a (partly) intact capacity for object attachment, and a supportive family may be important prerequisites for recovery. Two different courses of schizophrenia are illustrated by cases.

Adult↗
PubMed1998

A review of longitudinal studies of cognitive functions in schizophrenia patients.

Even though the idea that schizophrenia is a neurobehavioral syndrome has become a mainstream position, there is no consensus on the precise nature of the cognitive and neuropsychological impairment. Research on cognitive dysfunctions in schizophrenia has been directed toward discriminating stable dysfunctions (traits) from symptom-linked (state) deficits. A longitudinal study design is the only one that can provide answers to the question of the stability of psychological functions. This article reviews 15 studies with a followup of at least a year. The main conclusion drawn from these studies is that after the onset of schizophrenia, cognitive deficits are relatively stable over long periods. No support for a decline in cognitive functions is found. Thus, schizophrenia does not appear to be a degenerative process, but rather a static encephalopathy. Whether or not the cognitive deficits found in schizophrenia can be remediated is still an open question that needs to be examined.

Cognition Disorders↗
PubMed1998

Auditory laterality and selective attention: normal performance in patients with early-onset schizophrenia.

In this study, auditory laterality and selective attention were examined in patients with early-onset schizophrenia using a dichotic listening (DL) test. Deficient performance on this test has repeatedly been found in adult patients with chronic schizophrenia, indicating abnormalities in left hemisphere function. The hypothesis in the present study was that subjects with early-onset schizophrenia manifest deficits in DL test performance similar to adult chronic patients. A group of 19 patients with early-onset schizophrenia were compared with a group of 20 adolescents with attention-deficit hyperactivity disorder and a group of 30 normal adolescents. Results indicated no significant differences between the three groups on any of the measures. Alternative hypotheses are put forth to explain the findings, among them that deficits in DL performance may be secondary to long-time illness and/or drug treatment, and that these deficits may become apparent only after interaction with maturational neurodevelopmental changes during adolescence.

Adolescent↗
PubMed1998

No vigilance deficit found in either young schizophrenic or ADHD subjects.

Vigilance deficits have been found in both schizophrenic and ADHD subjects. The two patient groups have never been directly compared on any vigilance measure, however. In the present study 20 early-onset schizophrenics were compared to 20 ADHD adolescents on a Degraded Stimulus Continuous Performance Test (DS-CPT). A comparison group of 30 normal adolescents was also included. Results showed no significant differences between the three groups on any of the DS-CPT measures. Different hypotheses are put forth to explain the findings, among them that the task may be insensitive to identifying sustained attention deficits in adolescent populations.

Adolescent↗
PubMed1997

Stability in cognitive dysfunctions in schizophrenic patients.

The purpose of the present study was to classify cognitive dysfunctions in schizophrenic subjects according to a trait/state model. A sample of 15 patients was examined on 10 different cognitive measures in two distinctly different phases: an acute psychotic state and partial remission. To determine the degree of dysfunction at the two stages of illness, the schizophrenic patients were also compared to 14 non-psychiatric controls. Six of the 10 measures examined can be classified as cognitive deficits in schizophrenics. Four measures are possibly trait-dependent components: two backward masking scores and two long-term memory measures. A short-term memory measure is the only one that can be classified as an episode-linked factor. The other cognitive deficits found can be characterized as mediating vulnerability factors, i.e. they are more prominent in the acute psychotic state, but do not completely disappear during remission states.

Adolescent↗
PubMed1996

Backward-masking deficit in adolescents with schizophrenic disorders or attention deficit hyperactivity disorder.

OBJECTIVE: Backward masking is a cognitive task that involves the earliest phases of visual information processing. Disrupted task performance caused by a visual mask has been found repeatedly in schizophrenic patients; however, the specificity to schizophrenia of deficits in backward masking has received only limited study. METHOD: In this study 20 patients with early-onset schizophrenic disorders were compared to 20 adolescents with attention deficit hyperactivity disorder (ADHD) and 30 normal adolescents on a two-digit identification task in three backward-masking conditions: no mask, a short stimulus interval (33.0 msec), and a long stimulus interval (49.5 msec). RESULTS: The performance of the two groups of patients was similar, and both groups showed a statistically significant masking deficit after the long stimulus interval and a nearly significant deficit after the short stimulus interval in comparison with the normal subjects. CONCLUSIONS: Increased vulnerability to the masking stimulus was confirmed in schizophrenic subjects, but it is not specific to schizophrenia and is not accounted for by psychotic symptoms alone, since the subjects with ADHD performed similarly.

Adolescent↗
PubMed1995

Memory in schizophrenia and affective disorders.

The purpose of the present study was to investigate the stability of memory and information processing in schizophrenics and affectively disturbed patients. Twenty-two schizophrenics, eight affectives and 14 normal controls were tested twice, with an interval of approximately one year. Results showed that normals performed better than schizophrenics and affectively disturbed patients on almost all of the cognitive measures. The differences reached a level of significance on a reaction time test, a vigilance task and a long-term memory task. The only measure where the difference did not reach a level of significance was on a short-term memory test. Groups' performance to some extent changed over time on most of the measures, but the changes were not significantly different for different groups.

Adult↗
PubMed1995

Expressed emotion, communication deviance and schizophrenia. An exploratory study of the relationship between two family variables and the course and outcome of a psychoeducational treatment programme.

The relationship between expressed emotion (EE) and communication deviance (CD), and outcome in a group of early-onset schizophrenics after 2 years of psychoeducational treatment was examined. Patients' parents were assessed on EE and CD before and after the 2-year period. Outcome was measured by Global Assessment Scale (GAS) and relapse rate. Results showed that the correlation between CD and outcome was higher than between EE and outcome. In most of the patients who improved their GAS score during the treatment programme, their parents changed from high to low EE. CD proved to be more resistant to psychosocial intervention than EE.

Adolescent↗
PubMed1994

Mueller-Lyer illusion and size estimation performance in schizophrenics compared to normal controls.

A size estimation (SE) paradigm and the Mueller-Lyer (ML) illusion were used to examine perceptual disturbances in schizophrenics. 35 reliably diagnosed (DSM III-R) schizophrenics were compared to 20 subjects with no history of psychiatric illness. Perceptual distortions found in previous studies of schizophrenics were only to a certain extent confirmed in the present results. More overestimators were found among the schizophrenics than among the normals on the SE task. The schizophrenics, first of all the chronic patients, also proved to be more prone to the Mueller-Lyer illusion. A reason why the very clear differences between schizophrenics and normals found in previous examinations were not confirmed in the present study, might be that a reliable diagnostic instrument was for the first time used in this kind of study.

Adult↗
PubMed1994

The relationship between psychosocial and cognitive functioning in schizophrenic patients and expressed emotion and communication deviance in their parents.

The relationship between the family variables of expressed emotion (EE) and communication deviance (CD) and patient attributes of cognitive functions and clinical symptoms were examined. Eleven schizophrenic patients and their parents were evaluated at the beginning and the end of a 2-year treatment programme. The test battery for the patients included the Global Assessment Scale (GAS), Brief Psychiatric Rating Scale and a cognitive test battery. Parents' CD was evaluated with the Communication Conflict Situation and their EE level with Camberwell Family Interview. A significant correlation between patients' GAS score and mother's criticism score was found. The cognitive variable of backward masking was the measure that most consistently showed a close relationship to parent's EE level. The masking measure also differentiated significantly between parents who improved and parents who did not improve on EE during the 2-year treatment period. An empirical basis for a link between patients' cognitive functioning and parents' style of communication was not found.

Adolescent↗
PubMed1994

Cognitive dysfunctions and psychosocial treatment of schizophrenics: research of the past and perspectives on the future.

First, family research with the focus on the concept of communication deviance is reviewed. Then, the link between family factors and cognitive characteristics in the offspring is elaborated on. Research on cognitive dysfunctions with a basis in a vulnerability model is the theme of the next section. Finally, psychosocial and cognitive treatment programmes are outlined and discussed.

Cognition Disorders↗
PubMed1994

The Psychosis Project: outcome and cost-effectiveness of a psychoeducational treatment programme for schizophrenic adolescents.

The outcome of a psychoeducational treatment programme for very early-onset schizophrenics was compared with a standard reference treatment. The study sample consisted of 12 patients in each group. Clinical outcome was assessed by relapses during the 2-year treatment period and changes in psychosocial functioning as measured by the Global Assessment Scale. A cost-effectiveness analysis was also carried out. The results indicated that the most effective programme measured by relapse was also the cheapest: the psychoeducational programme. Patients with poor premorbid psychosocial functioning benefit most from this treatment. Decisive with respect to how effective the programme can be is the cooperativeness of patients' parents and their ability to change their emotional attitudes toward the patient.

Adolescent↗
PubMed1993

Memory functioning in chronic and non-chronic schizophrenics, affectively disturbed patients and normal controls.

Memory impairment has been reported among schizophrenics in several studies. There are a number of uncertainties in interpreting such deficits. The present study examined short- and long-term verbal memory in schizophrenic patients (n = 30), affectively distributed patients (n = 18) and normal controls (n = 18). Schizophrenics showed a significant decrease in memory test performance, compared with both normal controls and other psychiatric patients. Chronic schizophrenics seem to be characterized by qualitatively different memory functioning compared with non-chronic subjects. In a free recall task chronic subjects showed significantly decreased performance for the initial (primacy) and final (recency) items. Memory functioning was not correlated with performance on the Wisconsin Card Sorting Test. This could indicate a selective cognitive dysfunction of an amnesic nature in chronic schizophrenics.

Adult↗
PubMed1993

Backward-masking performance in chronic and nonchronic schizophrenics, affectively disturbed patients, and normal control subjects.

There is ample evidence that schizophrenics exhibit a backward masking deficit. To what extent other psychotic patients are susceptible to visual masking is still an open question. Likewise, differences between subgroups of schizophrenics have to be further explored. In the present study a computerized backward masking task was applied to 30 schizophrenics, 18 affectives and 20 normals. Results confirmed previous findings of a performance deficit in the schizophrenics. However, affectively disturbed patients performed even poorer than the schizophrenics. The most outstanding finding when the group of schizophrenics was split into different subgroups was the significant differences that appeared between chronic and nonchronic patients. The latter group (n = 8) performed as well as the normals, while the chronic schizophrenics (n = 22) showed evidence of a performance deficit comparable to the affectives.

Adult↗
PubMed1993

Stability in backward masking performance in schizophrenics, affectively disturbed patients, and normal subjects.

The purpose of the present longitudinal study was to investigate the stability of backward masking performance in schizophrenics and nonschizophrenic psychotic patients. Twenty-two schizophrenics, eight nonschizophrenics, and 14 normal controls were tested three times, with an interval of 1 year between each test session. A standard stimulus duration procedure was used. The relative onset intervals between the target and the mask was 16.5 msec or 33 msec. A no mask condition was presented before the two masking conditions. Results showed that masking performance is a stable phenomenon, for both psychiatric groups and for normal controls. Significant differences were found between schizophrenics and the normal controls, but not between the two psychiatric groups. Vulnerability to masking stimuli as a specific characteristic for schizophrenics is, thus, not supported in the present study. The results suggest that backward masking deficit is an enduring feature of psychotic disturbances.

Adult↗
PubMed1992

Vigilance deficits in schizophrenics and affectively disturbed patients.

Vigilance is a concept associated with the early levels of information processing. Vigilance deficits have repeatedly been found in schizophrenic patients. It has not been clear, however, whether such cognitive dysfunctions are specific to schizophrenics or not. In this study, 28 schizophrenics were compared with 19 affectively disturbed patients and 17 normals on a vigilance test that is a hybridization of a Continuous Performance Test (CPT) and a Span of Apprehension Test (SAT). The results showed that schizophrenics performed significantly below the normals only on target hits on the CPT. There were no differences between the two patient groups, either on number of correct hits or on commission errors. On the SAT measures, normals performed better than the two psychiatric groups on all measures. Schizophrenics had more commission errors than the affectives, but there were no differences between the two groups with respect to target hits. Neither CPT nor SAT deficit, thus, seem to be specific schizophrenic characteristics.

Adult↗