PubMed Health⌕ Search

Biomedical subjects

B ROSE

Publications and source records attributed to B ROSE.

At least 19 recordsLinked to original sources
PubMed1964

ISOLATION OF AN ANTIHISTAMINIC PRINCIPLE RESEMBLING TOMATINE FROM CROWN GALL TUMORS.

Antihistaminic activity was demonstrated previously in extracts of crown gall tumors by assaying in vivo. A crystalline substance isolated from the crude extracts has now been found to possess a high degree of potency against histamine, acetylcholine, bradykinin, and serotonin when assayed in vitro. The chemical characteristics of the substance resemble closely those of tomatine. When tomatine was investigated, it was found to have biological properties similar to those of the crystalline substances isolated from crown gall tumors. It seems likely that the antihistaminic properties of crown-gall tumor extracts are due to tomatine or a substance which closely resembles it.

Acetylcholine↗
PubMed1963

AN ANTIHISTAMINE-LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES.

A method for the extraction of an antihistamine-like substance (or substances) from human tissues is described. The method has demonstrated the presence of this active principle(s) in a large variety of human tissues, so far without exception. The substance(s) has a wide range of activity in antagonizing the in vitro effects of histamine, 5-hydroxytryptamine and bradykinin and the Schultz-Dale reaction on the guinea-pig ileum and rat uterus preparations.

Anaphylaxis↗
PubMed1962

Respiratory therapy for seasonal allergic rhinitis and asthma.

Repository therapy with an emulsified antigen preparation for pollen asthma and hay fever was used over the past three years. Overall results indicate that the response in the majority of patients was as good as that obtained with conventional preseasonal or perennial treatment. Reactions were noted in four of the 15 patients so treated during the first year of study, in 25 of 58 patients treated in the second year, and in 11 of 175 treated in the final year. These varied from mild to severe systemic reactions, some of which required hospitalization. With improvement and modification of the technique, such as the administration of the antigen in two injections rather than in a single injection, the incidence and severity of reactions were markedly reduced. The procedure is not without hazard; it requires great care, and initial experience is best obtained in a hospital environment.

Adult↗
PubMed1958

Detection of non-precipitating antibodies in sera of individuals allergic to ragweed pollen by an in vitro method.

A hemagglutination test capable of demonstrating antibodies in sera of ragweed-sensitive individuals has been described in detail. This test involves coupling of the antigen to rabbit erythrocytes via stable azo bonds. The antigen-coated cells are then suspended in the serum which is suspected to contain the homologous antibodies. The test has been shown to be specific and highly sensitive. Precipitating antibodies to ragweed pollen extract produced in experimental animals can be demonstrated in dilutions as high as 10(5) to 10(7), while antibodies to ragweed in allergic sera are detected only in dilutions of the order of 10(3). Positive results were obtained with all sera from treated or non-treated allergic individuals containing skin-sensitizing and/or blocking antibodies. Absorption of these sera with antigen-coated erythrocytes yielded a supernatant devoid of either skin-sensitizing, blocking, or hemagglutinating capacity. It is concluded that the hemagglutinating factor has the properties of a divalent antibody.

Allergens↗