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Biomedical subjects

B Radhakrishnamurthy

Publications and source records attributed to B Radhakrishnamurthy.

At least 127 records · Page 7Linked to original sources
PubMed1975

Lipoprotein-acid mucopolysaccharide complexes of human atherosclerotic lesions.

Lipoprotein-acid mucopolysaccharide complexes occurring in different types of human atherosclerotic lesions were isolated and partially characterized. Complexes from fatty streaks and fibrous plaques were extracted from pooled tissues with 0.15 M NaCl, purified by gel filtration, and fractionated by ultracentrifugation. Both low and very low density lipoproteins were present; low density lipoprotein was predominant. The complexes were analyzed for uronic acid, cholesterol, phospholipid, and Ca-2+ contents; there was no significant difference in the relative molar ratios between complexes from fatty streaks and fibrous plaques. Acid mucopolysaccharides were isolated from the complexes and identified by electrophoresis and enzymatic studies. Chondroitin sulfate C and hyaluronic acid were found in complexes from fatty streaks and fibrous plaques. Heparin was detected only in fibrous plaques.

Aorta↗
PubMed1975

The composition of connective tissue macromolecules from bovine respiratory system.

Connective tissue macromolecules, glycosaminoglycans, glycoproteins, collagen, and elastin were isolated from different parts of the respiratory system and characterized. The materials included bronchiolar tissue, gas-exchange tissue, lung pleura, and tracheal mucosa. The similarity of the macromolecular composition of lung pleura and tracheal mucosa suggests a common cellular component in these structures. The high concentration of GAG and collagen in bronchiolar tissue is consistent with the cartilagenous nature of this tissue. Particularly interesting is the high content of heparin in all pulmonary structures, a relatively greater content of hyaluronic acid in gas-exchange tissue, and a high content of heparan sulfate and dermatan sulfate in vascular tissues. Elastin also occurs as a major fibrous structure. Although the biologic role of these connective tissue macromolecules has not been established, certain functional relationships are inferred.

Animals↗
PubMed1975

A study of connective tissue macromolecules in skin of mice with goldthioglucose-induced obesity.

The effect of obesity on the connective tissue composition of skin was investigated in mice with goldthioglucose (GTG)-induced obesity. Four months after GTG treatment, the obese animals were sacrificed. Acid mucopolysaccharides, glycoproteins, collagen, and elastin were analyzed in the skin and compared to the controls. Total MPS in the skin from obese animals decreased, reflected mostly in hyaluronic acid. Chondroitin showed an increase over controls. The content of soluble glycoproteins varied; total carbohydrate and sialic acid of the glycoprotein tended to increase with obesity. Collagen and elastin both tended to decrease with obesity.

Animals↗
PubMed1975

Composition of connective tissue in aortas from rhesus monkeys during regression of diet-induced fatty streaks.

The aortic connective tissue components, collagen, elastin, and glycosaminoglycans were isolated and quantitated from monkeys with experimentally-induced fatty streaks, from monkeys on a diet allowing regression of these lesions, and from controls. Although no variations were noted for total, soluble, and autoclavable collagen based on concentration, nonautoclavable collagen was significantly less (p less than 0.02) and elastin was reduced (p less than 0.001) in tissues with fatty streaks. There were no significant differences in total glycosaminoglycan content among the groups, but a large increase of hyaluronic acid (50 to 220 per cent) and a decrease of chondroitin sulfate C (40 to 66 per cent) occurred after regression. Dynamic alterations of arterial connective tissue shown to occur with induction as well as with regression of fatty streaks indicate the importance of connective tissue in maintaining integrity of vascular structures.

Animals↗