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Biomedical subjects

B Radnai

Publications and source records attributed to B Radnai.

28 records · Page 2Linked to original sources
PubMed1976

Decreased cellular immune response of germ-free mice.

Cellular immune response to intracerebral lymphocytic choriomeningitis infection was studied in mice belonging to an identical strain but different in breeding conditions. In consequence of the cellular immune reaction on the leptomeninx, lymphocytic choriomeningitis developed and caused death in 100% of conventionally bred mice, whereas 80% of germ-free and 15% of mouse-pathogen-free mice failed to display lymphocytic infiltration of the leptomeninx and survived the infection as chronic virus carriers. This finding pointed to a deficient cellular immune response of germ-free and mouse-pathogen-free mice. The under-development of the lymphoid system due to the antigen-poor breeding conditions might be responsible for the deficiency.

Animals↗
PubMed1975

Course of lymphocytic choriomeningitis virus infection in young and aged mice.

The course and histological picture of intracerebral LCM virus infection was found to differ in mice with their thymus displaying an age-dependent involution and in young adult animals. Signs of lymphocytic choriomeningitis were absent in 75 per cent of the aged animals. The change of the characteristic clinical and histological picture referred to the decreased cellular immune response of aged animals, ascribed to the age-dependent involution of the thymus.

Age Factors↗