PubMed Health⌕ Search

Biomedical subjects

B Rasche

Publications and source records attributed to B Rasche.

12 recordsLinked to original sources
PubMed1979

[Clinical-functional emphysema diagnostics and immunological correlations (author's transl)].

By application of the correlation flow resistance/intrathoracic gas volume the lung emphysema is differentiated in quality within the scope of chronic obstructive lung diseases. For these groups immunoglobulins, the alpha1-trypsin activity in serum and the activity of further protease inhibitors were determined. There are no substantial variables in the different groups with regard to immunoglobulins. In the emphysema group alpha1-antitrypsin was a little reduced. This group included 2 patients with an alpha1-antitrypsin deficit. The two-dimensional separation of the inter-alpha-trypsin big inhibitor shows 3 areas which decrease significantly in case of severe emphysemata. The irritation of the inter-alpha-trypsin big inhibitor, i.e. in its turnover, parallel to the increasing degree of emphysema formation, is discussed.

Adult↗
PubMed1979

[The "IgA secretory component complex" in bronchial mucus in patients with chronic obstructive lung disease under different therapy (author's transl)].

The concentration of "IgA secretory component complex" in the bronchial mucus was measured under different therapeutical influences. The "IgA secretory component complex" is a most important factor of the exogenous immunodefense. The formation of the "IgA secretory component complex" was independent from the age of the patients and from the intensity of their airway obstruction. Therapy with glucocorticosteroids and antibiotics had no certain influence on the formation of the immunocomplex. We did not find any certain influence of gammaglobulin therapy in adult patients with chronic airway obstruction, neither on the "IgA secretory component complex" nor on the immunoglobulin G, A and M. Furthermore, the clinical course of the disease was not influence by this therapy.

Adult↗
PubMed1978

[Serum-concentrations of the immunoglobulins iga, ige and igm in children with different age and diseases with different aetiologies (author's transl)].

Normal values of the immunoglobulins, G, A and M in the serum were measured with the immunodiffusion-method by Mancini et al., (1965) (immunodiffusion-plates: Hyland-Travenol) for children in the age between 0-15 years. Moreover, we measured the course of the immunoglobulin development of some babies during hospitalisation. Here we found a wide individual range in synthesis of immunoglobulins.

Adolescent↗
PubMed1977

[The role of inter-alpha-trypsin-inhibitor (concentration of serum of childhood) (author's transl)].

The feeble monovalent, humoral protease inhibitor inter-alpha-trypsin inhibitor has to be regarded as inhibitogen for different secretory, low-molecular, polyvalent inhibitors. Kallikreine acts as inhibitor-releasing enzyme. The inhibitor levels in the serum were determined for children of different ages. Contrary to adult patients not showing a lack of inhibitogen as consequence of the disease, inhibitogen insufficiencies are rather frequent, particularly for prematures and newborns with respiratory distress and inflammatory diseases. Obviously, in early childhood the production of inhibitogen is not yet in full progress. In case of increased inhibitor consumption or excessive kallikrein consumption this condition results in an inhibitogen insufficiency.

Adolescent↗
PubMed1977

Plasma catecholamines in exercise induced bronchoconstriction.

Plasma nor-epinephrine (NE) and epinephrine (E) levels at rest and immediately after exercise were estimated in 8 patients with asymptomatic extrinsic allergic bronchial asthma. The patients had a normal airway resistance at rest and developed a marked bronchoconstriction (EIB) during exercise, which could be prevented by previous alpha-adrenergic blockade with phentolamine. In 7 control persons NE and E levels were measured also after beta-adrenergic blockade with propranolol. The following results were obtained: 1. At rest NE levels showed no significant differences between the groups. After exercise an increase of NE was observed in all groups, but in patients, even after phentolamine, and in normals after propranolol the increase was significantly higher than in the normal group within the control test. 2. No significant differences between the groups were found in E levels at rest and after exercise. Exercise caused no significant increase of E levels, except in the normals after propranolol application. 3. No significant correlation existed between NE levels and the increase of airway resistance after exercise. It is concluded that during exercise in asthmatics the sympathetic activity is enhanced, but the provocation of an EIB does not seem to be mediated by enhanced plasma NE levels.

Adrenergic alpha-Antagonists↗
PubMed1975

[Mucous membrane specific protease inhibitors in bronchial mucus in severe chronic obstructive bronchitis and in alpha 1-antitrypsin deficiency syndrome].

In the bronchial mucus of 40 patients with chronic obstructive airway diseases we measured proteolytic activities, the total protein concentrations, alpha1-antitrypsin, alpha1-antichymotrypsin, and the free and bound proteinase inhibitors together with the total proteinase inhibition against trypsin and chymotrypsin. Without exception we always found free proteinase inhibitors together with proteolytic activities. The free-to-bound inhibitor rate was approximately 1:1 alpha1-Antitrypsin and alpha1-antichymotrypsin was measured in sputum only in very low concentrations. One patient with alpha1-anti-trypsin deficiency had no alpha1-antitrypsin, but high concentrations of total proteinase inhibitor-free and bound being in the same relation - in his bronchial mucus. In the alveolar part of the lung, the humoral proteinase inhibitors were effective. In the bronchial part of the lung the specific mucosal inhibitors had the decided importance. The proteinase inhibition of the mucosa-specific inhibitors is probably of great importance for the pathogenesis of airway obstruction, while the humoral proteinase inhibitors are responsible for the pathogenesis of emphysema.

Adult↗
PubMed1975

[Effect of the protease inhibitor aprotinin on pulmonary function and on the inhibitory activity of sputum in patients with chronic obstructive bronchitis].

It has been investigated whether a substitution of protease inhibitor deficiency is indicated in case of chronic obstructive airway disease. As a therapeutic possibility, apronitin isolated from bovine organs (tyasylol), which in vitro inhibits sputum proteases up to 80 per cent was tested. Besides infusion, inhalation was chosen for application by which a protease inhibition could be attained. We observed an inhibition of the course of illness associated with a good tolerance of the preparation. Whether a therapy applying the addition of protease inhibitor is reasonable in the long run in chronic diseases cannot yet be concluded from these investigations.

Aerosols↗