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Biomedical subjects

B Rasmusson

Publications and source records attributed to B Rasmusson.

26 records · Page 2Linked to original sources
PubMed1980

Bone abnormalities in patients with medullary carcinoma of the thyroid.

The frequency and appearance of bone abnormalities in patients with medullary carcinoma of the thyroid were compared with those of patients with other thyroid carcinomas. Only in patients with medullary carcinoma the following abnormalities were found: dolichocephaly, prognathism, anterior chest deformity, bone cysts. Schmorl nodes, spina bifida, slipped femoral epiphysis, pes cavus and marfanoid body build. Not only patients with medullary carcinoma of the thyroid as part of multiple endocrine neoplasia, but also patients with otherwise unrelated medullary carcinoma had bone defects. The cause of the bone abnormalities is probably a defect of a stem cell in the embryonal neural crest rather than a sustained effect on bone tissue of the tumor produced calcitonin.

Adolescent↗
PubMed1980

Changes in serum calcitonin in patients undergoing thyroid surgery.

In order to study the influence of calcitonin as a calcium lowering factor during thyroid surgery, we measured calcitonin, calcium, parathyroid hormone, phosphate and alkaline phosphatases in serum of 10 euthyroid patients undergoing minor thyroid surgery. A significant increase was found in serum calcitonin during the first 48 hours postoperatively (p less than 0.01), as well as a transient decrease in serum calcium ( less than 0.01). Serum parathyroid hormone remained almost constant. The results suggest that the release of calcitonin from the traumatized thyroid tissue is the first step in the development of hypocalcaemia in patients undergoing thyroid surgery rather than an impairment of the parathyroid function.

Adult↗
PubMed1979

Treatment of medullary carcinoma of the thyroid. Value of calcitonin as tumour marker.

Changes in immunoreactive serum calcitonin were measured in 11 patients with medullary carcinoma of the thyroid, before and after surgery, external high-voltage irradiation, 131I therapy, and chemotherapy. Measurement of serum calcitonin concentration was found to be a useful method for evaluating tumour mass and function during treatment. Contrary to previous reports, treatment with 131I resulted in a positive effect on serum calcitonin and diarrhoea, and in one patient with bone metastases these disappeared. No response was found following chemotherapeutic regimes. Calcitonin was found to be more sentitive than palpation, radiography, and scintigraphy for determining the amount of tumour tissue, but a definite correlation between this amount and the concentration of serum calcitonin was not found.

Adult↗
PubMed1978

Magnesium and phosphate in the serum of patients with medullary carcinoma of the thyroid.

Magnesium, phosphate, immunoreactive parathyroid hormone and calcium were measured in the serum of nine patients with medullary carcinoma of the thyroid and high serum calcitonin, and compared with the values in nine patients with normal serum calcitonin. Serum phosphate was significantly higher in the group of patients with high serum calcitonin (P less than 0.025). No correlation was observed between the serum concentrations of magnesium and calcitonin, nor of immunoreactive parathyroid hormone and calcitonin.

Calcitonin↗
PubMed1978

Parathyroid hormone and calcitonin in serum of patients with mammary carcinoma.

Immunoreactive parathyroid hormone and calcitonin in serum were measured in 34 normocalcemic patients with mammary carcinoma. The mean value of parathyroid hormone was significantly higher in 26 patients with bone metastases than in 8 patients without (p less than 0.025). One patient with bone metastases had slightly raised calcitonin in serum. No difference as to parathyroid hormone values between the groups of previously irradiated and non-irradiated patients was found. A possible explanation of the normocalcemic hyperparathyroidism is presented.

Adult↗