PubMed Health⌕ Search

Biomedical subjects

B Read

Publications and source records attributed to B Read.

12 recordsLinked to original sources
PubMed2001

A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease.

BACKGROUND: Preclinical studies suggest that glutamate antagonists help ameliorate motor fluctuations in patients with PD treated with levodopa. METHODS: In a multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study, the authors assessed the safety, tolerability, and efficacy of the glutamate receptor blocker remacemide hydrochloride in 279 patients with motor fluctuations treated with levodopa. The primary objective was to assess the short-term tolerability and safety of four dosage levels of remacemide during 7 weeks of treatment. Patients were also monitored with home diaries and the Unified PD Rating Scale (UPDRS) to collect preliminary data on treatment efficacy. RESULTS: Remacemide was well tolerated up to a dosage of 300 mg/d on a twice daily schedule and 600 mg/d on a four times daily schedule. The most common dosage-related adverse events were dizziness and nausea, as observed in previous studies of remacemide. The percent "on" time and motor UPDRS scores showed trends toward improvement in the patients treated with 150 and 300 mg/d remacemide compared with placebo-treated patients, although these improvements were not significant. CONCLUSION: Remacemide is a safe and tolerable adjunct to dopaminergic therapy for patients with PD and motor fluctuations. Although this study had limited power to detect therapeutic effects, the observed improvement is consistent with studies of non-human primates with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian signs and symptoms. Additional studies are warranted to confirm these results over an extended period of observation, and to explore the potential neuroprotective effects of remacemide in slowing the progression of PD.

Acetamides↗
PubMed1994

Inbreeding: one word, several meanings, much confusion.

Because conservation biologists must frequently deal with small populations, inbreeding (a frequent consequence of small population size) has played a central role in many genetic management programs. However, the word "inbreeding" has several, often contradictory meanings, and a failure to distinguish among these meanings has caused much misunderstanding on the role of inbreeding in genetic management. Three different biological meanings of inbreeding are discussed in this paper: (1) inbreeding as a measure of shared ancestry in the paternal and maternal lineages of an individual; (2) inbreeding as a measure of genetic drift in a finite population, and (3) inbreeding as a measure of system of mating in a reproducing population. The distinction and use of these different measures of inbreeding are discussed and illustrated with a worked example, the North American captive population of Speke's gazelle (Gazella spekei). It is shown that these different meanings of the word inbreeding must be kept separated, otherwise erroneous management recommendations and evaluations can occur. On the positive side, the different measures of inbreeding when used jointly can be a powerful management tool precisely because they measure different biological phenomena.

Animals↗
PubMed1994

DNA fingerprinting in Speke's gazelle: a test for genetic distinctness, and the correlation between relatedness and similarity.

In the absence of pedigree information, the determination of genetic distinctness of populations can only be made by genetic methods. Using DNA fingerprinting on the North American captive herd of Speke's gazelle Gazella spekei, we were able to address two hypotheses. First, two new individuals were found to have come from a genetically distinct population (P = 0.008, permutation test), and represent potential new founders to be added to the population. Secondly, genetic similarity was not significantly correlated with relatedness under extreme inbreeding and very close relationship (coefficient of relationship range 0.304-0.717).

Animals↗
PubMedDate not supplied

HK/LK polymorphism and its genetic determination in Speke's gazelle.

Concentrations of potassium (K) and sodium (Na) were determined in the erythrocytes of 28 members of an interbreeding herd of Speke's gazelle. The distribution of K concentrations and Na/K concentration ratios suggested the presence of the high-K/low-K (HK/LK) polymorphism known in erythrocytes of domestic bovids. The pedigree of the herd of gazelles is known completely, permitting examination of the inheritance of HK/LK polymorphism by overlaying the distribution of phenotypes on the pedigree. Statistical analyses clearly indicate a strong genetic component in the phenotypic variability that is entirely consistent with a single autosomal locus, two-allele mode of inheritance, with the LK allele being dominant. This is the first demonstration of HK/LK polymorphism in a wild bovid species. The evidence indicates that HK/LK polymorphism is of considerable evolutionary age, is of monophyletic origin, and is maintained by selection.

Alleles↗
PubMedDate not supplied

Halitosis research.

Explore the source record for details and available documents.

Chlorine Compounds↗
PubMedDate not supplied

Diagnosis of congenital dislocated hips (CDH).

Radiology imaging, along with clinical orthopedic assessments, plays an important role in the diagnosis and treatment of Congenital Dislocated Hips. The validity of the radiologic examinations relies heavily on the examiner or technologist. This article explains some of these examinations and describes the benefits, disadvantages, and important facts to be aware of while performing them.

Female↗