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Biomedical subjects

B Resch

Publications and source records attributed to B Resch.

At least 19 recordsLinked to original sources

[Prenatal diagnosis of measles infection by transabdominal puncture of the umbilical vein].

Prenatal diagnosis of fetal rubella infection was reported. Maternal infection took place at the 13th week of gestation. Percutaneous umbilical fetal blood sampling was performed at the 22nd week of gestation. 1:400 titre of rubella specific immunoglobulin in fetal sera confirmed the rubella infection. A normal baby was born by cesarean section at term and subsequent ophthalmologic, cardiologic, audiologic follow-up have not revealed any alteration in infant's development. Clinical management of fetal rubella infection was discussed.

Adult

[Precipitating factors for shunt insufficiency in post-hemorrhagic hydrocephalus in the premature infant].

Between January 1984 and March 1989 twenty-seven low birth weight infants (mean birth weight 1351 gm, mean gestational age 30 weeks) required shunts after development of a posthaemorrhagic hydrocephalus. Revision of the shunt occurred in 78% of the patients with a range of 1 to 11 revisions. Obstruction of the ventricular catheter was the main cause of mechanical complications that occurred in 75%. Preterm infants weighing less than 1000 gm revealed an enormous infection rate of 71%. Initial shunt placement in the first 8 weeks of life was more likely to need shunt revision (94%) than that placed at older age (44%). There was no difference between the type of shunt and percentage of shunt revision, but the Heyer-Schulte system in comparison with the Codman Uni shunt was more likely to have mechanical complications. Infants with Grade IV haemorrhage required the same percentage of revisions as those with Grade III haemorrhage. There was no association between preoperative therapy and the need for shunt revision. A great amount of erythrocytes and very low glucose levels in the preoperative CSF were more likely to predict shunt revision than predicted by the CSF protein.

Birth Weight

Biological, microscopic and scanning electron microscopic investigations of the effects of postinor /d-norgestrel/ in rabbits.

The contraceptive effect of d-norgestrel given immediately after copulation in various quantities was investigated in rabbits. It was established that the effect is dose-dependent. A correlation was found between the amount of dose administered and the changes taking place on the surface of endometrium. It can be suggested that d-norgestrel alters the surface of the endometrium to such an extent that nidation is unable to take place; therefore, it can be used for postcoital contraception at any time.

Animals

"Menstrual induction" with Sulproston.

The PGE2-analogue Sulproston (16-phenoxy-omega-17,18,19,20-tetranor-PGE2-mythylsulfonylamide) was administered to 200 medically and gynecologically normal women who were 17 +/- 0.4 days beyond their expected menstrual period and who had a positive pregnancy test. The intramuscular impact dose (500 micrograms repeated after 4 hours) caused an immediate tonic uterine contraction which compromised the estradiol 17 beta, progesterone and chorionic gonadotropin production within the fetoplacental unit, and thereby allowed the evolution of cyclic uterine activity, cervical dilatation and tissue expulsion. Pregnancy termination was complete in 92% of women, 5.5% required surgical curettage and 2.5% were given a second Sulproston treatment 2-3 weeks after the first to remove retained tissue from the uterus. The medical induction of menstruation was preferred by 83% of the women who had previously experienced surgical termination of pregnancy. Normal menstruation resumed in all women after 36 +/- 0.9 days. The majority of 42 women questioned found Sulproston a satisfactory, safe, simple and effective drug regimen for "menstrual induction".

Abortifacient Agents, Nonsteroidal

Human fetal and adult spleen phospholipids and their fatty acid composition.

Total phospholipid contents and the individual phospholipid components of human adult and fetal spleens from 17--18 and 23--24 week's pregnancies composition of sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, diphosphatidylglycerol and phosphatidic acid studied in human adult, 17--18 and 23--24 week fetal spleens.

Chemical Phenomena

Cross reactivity of digitoxin and spironolactone in two radioimmunoassays for serum digoxin.

We measured the cross reactivity of two medications--digitoxin and spironolactone--in two digoxin radioimmunoassay (liquid and solid-phase) kit procedures. Both tests showed similar average percentages of cross reactivity with digitoxin (7.2 and 8.9% for intravenous, and 11.9 and 10.9% for oral administration), but no cross reactivity with spironolactone or its metabolites after equal intravenous or oral doses.

Cross Reactions