Biomedical subjects
B Rettig
Publications and source records attributed to B Rettig.
Breast cancer in Nebraska: recent trends in incidence, mortality, and screening.
Data from the Nebraska Cancer Registry indicate that the State's female breast cancer incidence rate did not increase or decrease significantly during the period 1987-1993, although the percentage of in situ diagnoses increased from 8% to 13%. Similarly, breast cancer mortality among Nebraska women has remained relatively constant during the past decade (1985-1994). According to Nebraska's Behavioral Risk Factor Survey, screening mammography rates among Nebraska women have shown striking increases in recent years: in 1994, nearly half (48%) of all women 50 and older reported that they had had a mammogram within the past year, up from 24% in 1988. Nebraska's breast cancer incidence, mortality, and screening rates remain lower than U.S. rates.
[Treatment of hyperkinetic children in the home environment].
Twenty children with hyperkinetic disorders with or without conduct disorders were treated in a home-treatment setting, as an alternative to inpatient treatment, by nurses specialized in child psychiatry and under the constant supervision of an experienced child psychiatrist. Conduct disorders were influenced positively in the child's natural surroundings. Parents were trained as co-therapists. Good cooperation by the family is required for therapy to have positive effects. Case studies serve to illustrate how treatment can be conducted at home.
Breast cancer screening in Nebraska: an update.
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Breast cancer screening: recent trends in the use of mammography in Nebraska.
Although the efficacy of screening mammography has been surrounded in controversy of late, the evidence that it can reduce breast cancer mortality among women 50-74 years of age is extremely sound. In Nebraska, data from the state's Behavioral Risk Factor Survey show, that during the years 1988 to 1992, the percentage of women age 50 years and older who had ever had a mammogram rose from 50% to 65%, while the percentage of women of the same age who had had a mammogram within the past year rose from 24% to 34%. Nebraska BRFS data also show that the percentage of women 50 years of age and older who have had a mammogram within the past year varies considerably by age, income, education, and county of residence. Among women who have not had a mammogram within the past year, 66% reported that they had seen a physician within the past year for a routine check-up. Prompt and appropriate follow-up of abnormal findings by both physicians and health-care organizations is also essential to ensure the maximum benefit of screening mammography.
Breast cancer screening: recent trends in the use of mammography in Nebraska.
Although the efficacy of screening mammography has been surrounded in controversy of late, the evidence that it can reduce breast cancer mortality among women 50-74 years of age is extremely sound. In Nebraska, data from the state's Behavioral Risk Factor Survey show, that during the years 1988 to 1992, the percentage of women age 50 years and older who had ever had a mammogram rose from 50% to 65%, while the percentage of women of the same age who had had a mammogram within the past year rose from 24% to 34%. Nebraska BRFS data also show that the percentage of women 50 years of age and older who have had a mammogram within the past year varies considerably by age, income, education, and county of residence. Among women who have not had a mammogram within the past year, 66% reported that they had seen a physician within the past year for a routine check-up. Prompt and appropriate follow-up of abnormal findings by both physicians and health-care organizations is also essential to ensure the maximum benefit of screening mammography.
Evidence for cytomegalovirus and human immunodeficiency virus infection of the retina in AIDS.
Characteristic ophthalmopathological features of retinal lesions in a patient with the acquired immunodeficiency syndrome (AIDS) are reported. In situ hybridization, immunohistochemistry and electron microscopy revealed severe unilateral cytomegalovirus (CMV) retinitis. The opposite retina which was not involved by CMV showed nonspecific signs of ischaemia in the nerve fiber layer corresponding to cotton-wool spots. Occasional cells of both retinas were positively stained by a mouse monoclonal antibody to the p24 HIV-1 antigen indicating infection of retinal cells by HIV. It is suggested that HIV may directly or indirectly damage retinal tissue and interact with opportunistic pathogens, thus leading to a variety of ocular abnormalities associated with AIDS.
[The effect of cumulus oophorus on the fertilization in vitro of mature oocytes of cattle].
The effect of the cumulus oophorus on fertilisation was investigated by 478 in vitro maturated bovine oocytes. Culturing revealed that the amount of defects on the pellucid zone and in ooplasm of cumulus-free oocytes was higher than that in oocytes cultured in the cumulus-oocyte complex (38 percent or 77/203 versus eleven percent or 30/275). Insemination of the cumulus-oocyte complex (COC) seemed to increase the fertilisation capability of bovine oocytes (63 percent or 70/111), though its penetration rate was only 45 percent (111/245) and was thus below that of cumulus-free oocytes (55 percent or 69/126). Use of COC is recommended as basic material for in vitro maturation and fertilisation.
Morphologic criteria of progression and regression of cardiac hypertrophy.
The heart is able to adapt itself to a demanded load by increasing (hypertrophy) or decreasing (regression of hypertrophy) its muscular mass within a wide range. Overstressing of the ability of adaptation is accompanied by degenerative changes of myocytes. Semiquantitative investigations of endomyocardial biopsies (EMCBs) of patients with dilative cardiomyopathy (DCM) and hypertrophic nonobstructive cardiomyopathy (HNCM) show a fibrosis of the interstitial space, as well as almost similar changes of myofibrils and mitochondria. A reduced number of myocytes in hearts with DCM could explain the decreased functional capacity. Quantitative investigations of endomyocardial biopsies and myectomy specimens in patients with hypertrophic obstructive cardiomyopathy have revealed that hypertrophy and, to a certain extent, hyperplasia of muscle fibers cause asymmetrical thickening of the septum. Experimental investigations of the regression of training-induced hypertrophy in rats have shown that nearly all parameters (cardiac weight, thickness of muscle fibers, myofibrillar mass, interstitial space, and capillary width) returned to the values of controls 14 days after termination of a swimming training regimen. A significantly higher density of capillaries after regression of muscle fiber hypertrophy compared to controls points to a temporal dissociation in the regression of myocyte size and capillary network. Decrease in RNA concentration and an increased number of autophagic vacuoles give evidence for decreased anabolism and increased catabolism may occur during regression. In humans, fibrosis of the myocardium and scar formation explain the irreversibility of cardiac hypertrophy, as observed in some patients with valvular heart disease, despite valve replacement.
[Malignant hyperthermia. A case report (author's transl)].
An exceptionally serious case of malignant hyperthermia in a 17 year old male is presented. A detailed description of the case is given concerning symptomatology, course, laboratory data and morphologic alterations. Our patient died after 7 weeks of intensive care due to therapy resistant septicemia and coagulation disorder. Intense adynamia and advanced muscular atrophy were present. Necropsy showed regionally different extensive lysis of skeletal muscles. In the discussion the advantage of an "ice gravel" producing machine in cooling measures, the necessity of higher procaine doses and problems of long term therapy in trauma patients coincidentally affected with malignant hyperthermia, are stressed.