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Biomedical subjects

B Rodu

Publications and source records attributed to B Rodu.

63 records · Page 4Linked to original sources
PubMed1986

Interuniversity microscopic slide exchanges: a mechanism for peer review and continuing education in oral pathology.

One thousand seven hundred and three consecutive cases from a microscopic slide exchange with 10 institutions were evaluated for extent of agreement (or disagreement) defined as: A) complete agreement (85.8%). B) Disagreement--difference in diagnostic terminology, no significant pathologic or clinical implications (1.4%); C) disagreement--difference in diagnosis with pathologic significance only (7.7%); C1 disagreement--difference in diagnosis with pathologic significance only, radiographic interpretation necessary (1.1%); D) disagreement--major significance for prognosis and/or treatment (4.0%). Trends in disagreement were identified in the following tissue/location categories: mesenchymal lesions, minor salivary gland tumors, odontogenic tumors, fibro-osseous lesions, and benign epithelial lesions. These are discussed in relation to the oral pathology literature. All disagreements with significance for prognosis and/or patient treatment were evaluated retrospectively in an attempt to resolve the disparities. The implications for peer review, continuing education, and teaching programs are addressed.

Diagnosis, Differential↗
PubMed1985

Tooth extraction by orthodontic force after radiation therapy: report of case.

This report presents a therapeutic approach to orthodontic tooth extraction in a patient at high risk for the development of osteoradionecrosis with conventional techniques. The rationale for this procedure is discussed in detail, combining principles of radiation biology, clinical radiation therapy, and biomechanics of tooth movement.

Adult↗
PubMed1984

Peutz-Jeghers syndrome and cancer.

A 27-year-old white woman with Peutz-Jeghers syndrome (PJS) associated with a rare but distinctive ovarian tumor, the sex cord tumor with annular tubules (SCTAT), is discussed. Pertinent oral manifestations of PJS and chemotherapy complications are illustrated by the case report. Traditionally, patients exhibiting PJS have not been considered at increased risk of cancer development. This case, coupled with a review of the recent literature, suggests that these patients are, indeed, at increased risk of malignant lesions of several organ systems.

Adult↗
PubMed1984

Oral candidiasis in cancer patients.

Oral candidiasis in cancer patients is an infection for which inconsistent diagnostic and therapeutic strategies currently prevail. Recent studies have shown its potential importance in the development of systemic candidiasis. A clinical and cytologic study was undertaken on 52 consecutive cancer patients admitted to our institution. Although the incidence of clinical candidiasis was low (8%), 27% of patients harbored evidence of subclinical colonization by Candida. In addition, a significant correlation was found between candidal colonization and low absolute lymphocyte counts. The significance of these findings in relation to systemic candidiasis and rationale for therapy are discussed.

Candida↗
PubMed1983

Oral manifestations of the chronic graft-v-host reaction.

The graft-v-host reaction (GVHR), a major complication of bone marrow transplantation, is a complex immunologic phenomenon with a diverse and often confounding presentation. After reviewing major systemic manifestations, this report details the clinical and pathological oral findings of chronic GVHR. The reaction is characterized clinically by a mucosal lichenoid keratosis. Pathological findings resemble mucosal lichen planus, and minor salivary gland show lesions similar to those of Sjögren's syndrome. These oral findings are potentially valuable in the early recognition and follow-up of chronic GVHR. The differential diagnosis includes viral infections and chemotherapeutic drug toxicity, but these can usually be eliminated from consideration by viral cultures and temporal correlation of symptoms, respectively.

Adult↗
PubMed1981

Aggressive fibromatosis involving the paramandibular soft tissues. A study with the aid of electron microscopy.

The distinction at the level of light microscopy between aggressive fibromatosis and low-grade malignancies with fibroblastic features may be difficult. An electron microscopic study of four cases of aggressive fibromatosis of the mandibular soft tissue was undertaken to determine whether any ultrastructural characteristics could be identified that would aid in a more uniform distinction between these lesions. The pertinent findings include the identification of cells of fibroblastic derivation showing a range of organelle-poor to organelle-rich features, cytoplasmic microfibrils, and dilated rough endoplasmic reticulum profiles. These features are discussed in the light of previously published findings of other forms of aggressive fibromatosis and closely related lesions. The study reaffirms that although electron microscopy may be useful in confirming the cell of origin in these lesions, the accurate diagnosis of fibrous tumors still rests with the proper correlation of clinical and light microscopic features. Clinical follow-up of the cases supports both the diagnosis of aggressive fibromatosis and the recommended treatment of adequate local excision.

Adolescent↗
PubMedDate not supplied

Oral candidiasis in patients with diabetes mellitus: a thorough analysis.

It has generally been assumed that oral candidiasis occurs with increased frequency in patients with diabetes mellitus. To evaluate this, we compared the frequency and severity of oral Candida colonization in 60 patients with insulin-dependent diabetes mellitus (IDDM) admitted to a low-intensity-care diabetes unit with those in 57 age- and sex-matched controls. Swabs taken from the tongue and buccal mucosa were examined by cytology rather than culture because of the discrimination provided by the former. Cytological smears were classified according to the presence and morphology of the Candida organisms. Overall, a significant difference in Candida species colonization was found between patients with diabetes (75.0%) and controls (35.1%) (P less than .005). In the diabetic group, no relationship was found to recent use of antibiotics, total or differential white blood cell count, serum glucose, presence of diabetic retinopathy, or glycosylated hemoglobin values. We conclude that in IDDM there is a predisposition to oral candidiasis and that this predisposition is independent of glucose control.

Adolescent↗