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Biomedical subjects

B Rogala

Publications and source records attributed to B Rogala.

At least 19 recordsLinked to original sources
PubMed2001

[Nitric oxide (NO) in the pathophysiology of asthma and interstitial lung diseases].

NO is an important mediator of immune and inflammatory responses. NO is produced from L-arginine by three isoforms of nitric oxide synthase (NOS), neuronal (nNOS; NOS1), endothelial (eNOS; NOS3) and inducible (iNOS). Exhaled NO has been shown to be increased in asthma and has been put forward as a marker of airways inflammation. Moreover, increased production of NO and peroxynitrite may be responsible for the oxidative damage and fibrosis seen in interstitial lung diseases. The present review focuses on clinical and laboratory studies that are aimed at identifying the role of NO in the physiopathology of these disorders.

Asthma↗
PubMed2001

The role of R576Q polymorphism of interleukin-4 receptor alpha gene in atopy: results of a family-based study design.

INTRODUCTION: There is strong evidence that the R576 allele of interleukin-4 receptor alpha gene (IL-4R) might predispose to atopy. To test this hypothesis, we examined the association between the R576Q polymorphism and atopy in a Polish population using the family-based study design. MATERIALS AND METHODS: 44 atopic patients (age range from 11 to 34 years) with pollen and house dust mite allergy or/and mild asthma together with both parents were studied. The R576Q polymorphism of the IL-4R gene was genotyped in each patient and both parents, respectively, using the PCR-based protocol. The results were analyzed by the transmission disequilibrium test (TDT). The total IgE serum level, allergen-specific IgE to the common aeroallergens, IL-4, and sIL-4Ralpha were assessed in each patient and both parents. RESULTS: In the TDT test the R576 and Q576 alleles were transmitted from the heterozygous parents to the affected offspring 20 and 15 times, respectively (McNemar test: p = 0.19). The results of the transmission disequilibrium test did not reach statistical significance. Thus, the R576 allele might contribute to the pathogenesis of allergic diseases in patients with high total IgE serum level (p < 0.05). A larger study group has to be studied to prove the observed linkage and association.

Adolescent↗
PubMed2000

[Mosquito bites hypersensitivity: clinical and therapeutic approach].

Hypersensitivity to mosquito bites is an underestimated clinical and therapeutical problem. When feeding, female mosquitoes inject saliva, containing antigens and potentially toxic substances, into the human skin. The cutaneous response to mosquito bites is expressed as pruritus and oedema. The systemic symptoms are observed rarely. Nevertheless, the symptoms caused by mosquito bites are troublesome. In this paper clinical picture of mosquito bites consequences and up-to-date conceptions pathomechanism relating to their are shown. Moreover, prophylactic and therapeutical approaches are presented.

Animals↗
PubMed2000

[The analysis of the selected epidemiological aspects in patients with inhalant allergy treated at the Allergology Outpatient Clinic in Zabrze].

The study was designed to analyse the selected epidemiological aspects in patients with inhalant allergy treated at the Allergology Outpatient Clinic in Zabrze from 1989 till 1994. The analysis was based on the data from the files of 11,540 patients. The data of the pollinotic patients (1571 subjects) and of those with bronchial asthma (521 subjects) were analysed with regard to frequency of the diseases, place of residence (urban or country area), sex, date of birth, age when the illness had occurred, hereditary factors, type of allergens and the coexistence of other atopic diseases. Additionally, a group of 317 patients (183 men and 134 women) with inhalant allergy in period studied was randomly chosen to estimate the concentration of IgE. In the group of 28 patients with pollinosis the serum level of specific IgE antibodies against grass (g5, g6), trees (t3, t4) and weeds (w6, w9) was evaluated as well. The relationship between the concentration of IgE and sex, age, the month of birth, family history was estimated.

Adolescent↗
PubMed2000

[Genetic aspects of atopic disorders].

Atopy tends to run in families, suggesting the existence of a genetic predisposition. The review of the literature data concerning the issue has been performed.

Adult↗
PubMed1999

Soluble CD23 in allergic diseases.

CD23, a differentiation marker of B cells is identified with the low-affinity receptor for IgE--FcepsilonRII. The CD23 molecule is continuously cleaved by autoproteolysis into soluble fragments called sCD23, considered as a multifunctional cytokine. sCD23 is supposed to play an important role in IgE synthesis. IgE is a hallmark of atopy and its overproduction is a characteristic feature of allergic diseases. The aim of this study was to determine sCD23 (25 kDA) serum levels in patients with inhalant allergy and hymenoptera venom-induced allergy with relevance to IgE system. The trial consisted of 18 patients with pollinosis, 25 with house dust mite allergy and 12 with hymenoptera venom-induced allergy. Eighteen healthy volunteers without signs of atopy served as a control group. Serum levels of sCD23 (25 kDa), total IgE and allergen specific IgE were measured as well. The results were presented as median value, 25-75% range and a total value range. Nonparametric tests (the U Mann-Whitney test, Kruskal and Wallis test and Spearman's correlation rang test) were used. In patients with allergic disorders serum levels of sCD23 were significantly higher than in the control group (p<0.05). No correlation between IgE levels and sCD23 was detected in all the investigated groups. sCD23 does not appear to be a hallmark of allergic diseases, however serum level of that molecule is significantly elevated in patients suffering from allergic disorders. No correlation between sCD23 and IgE has been observed. sCD23 serum level has no relevance to the types of allergic diseases.

Adolescent↗
PubMed1999

[Platelet aggregation test in specific immunotherapy].

The aim of study was to investigate the effect of a specific immunotherapy (sIT) on the results of the platelet aggregation test (agregometr, chronolog Corp. Broomall, Pa model 345) in patients with inhalant allergy. The trial consisted of 57 patients with seasonal allergic rhinitis (exclusively allergic to grass pollens) and 55 patients with perennial allergic rhinitis sensitive to house dust mite Dermatophagoides pteronyssinus. sIT was applied in only 29 patients suffering from pollinosis and 27 sensitive to house dust mite. The remaining patients were subjected to routine pharmacotherapy alone. The control group consisted of 30 laboratory workers with no history of atopy. Platelet aggregation test was performed before sIT and after 2 years course of treatment and finally revealed the partial improvement of the impaired aggregation capacity of platelets which suggest their involvement in the mechanism of sIT. There was no correlation between the platelets function and IgE serum level and the clinical efficacy of sIT as well.

Adolescent↗
PubMed1999

[Coexistence of bronchial asthma and diabetes mellitus type 2--retrospective analysis].

Bronchial asthma and diabetes mellitus type 2 are often found among adult patients. However, coincidence of these two diseases is very rare. The aim of the study was the retrospective analysis of all patients with bronchial asthma and diabetes mellitus type 2 hospitalised in Department and Clinic of Internal Diseases and Allergology in Zabrze, Silesian School of Medicine in Katowice in 1988-1997. Diabetes mellitus type 2 was diagnosed according to WHO criteria of 1985 and bronchial asthma was diagnosed with the use of American Thoracic Society criteria. Bronchial asthma and diabetes mellitus type 2 occurring together were found in 18 patients (0.3% of all hospitalized patients). In most patients the symptoms of bronchial asthma preceded the diagnosis of diabetes mellitus by a few years. All these cases were heterogeneous in terms of the duration of the diseases, clinical picture, and therapeutical approaches. In patients with bronchial asthma the existence of diabetes mellitus type 2 was not related to use of glikocorticosteroids. Patients in whom the coexistence of bronchial asthma and diabetes mellitus type 2 was found should be subjects of further studies to extend our knowledge of patomechanism of these diseases.

Adult↗
PubMed1999

Chemokine RANTES in atopic dermatitis.

Chemokines play a key role in inflammatory diseases. The aim of this study was to estimate chemokine RANTES in the sera of patients with atopic dermatitis (AD) and to analyze the correlation between RANTES serum level and the immunological and clinical parameters of the disease. Serum levels of RANTES (ELISA; R&D Systems), total IgE and specific IgE (FEIA; Pharmacia CAP System) were estimated in 24 patients with AD, 28 patients with pollinosis (PL) and 22 healthy nonatopic subjects (HC). The division of the AD group into a pure AD (pAD) subgroup, without a coexisting respiratory allergy, and a subgroup of patients with AD and a respiratory allergy (AD+AO) was done according to Wütrich. Levels of RANTES were higher in the AD group than in the HC group and the PL group. RANTES levels did not differ among subgroups with various clinical scores and between the pAD and AD+AO subgroups. There were no correlations between levels of RANTES and total IgE. Significant positive correlations between serum levels of RANTES and Dermatophagoides farinae and cat dander-specific IgE were found in the AD group. We conclude that the serum level of chemokine RANTES differs patients with AD from patients with PL. The increase of RANTES concentration in the serum of patients with AD depends neither on a clinical picture nor an IgE system.

Adolescent↗
PubMed1999

[The immunological background of the allergen vaccines application].

The review and critical estimation of the studies concerning the mechanism of action of SIT was performed. The presented data give the reasons to view the allergen vaccines as the immunomodulators motivating simultaneously the applicability of these agents as the causative treatment of the allergic diseases.

Allergens↗
PubMed1998

Risk and safety of immunotherapy.

The risk and safety of specific immunotherapy (SIT) has been the subject of many well-designed studies since it was introduced. Most authors consider SIT an efficient and safe mode of treatment despite the occurrence of life-threatening anaphylactic reactions. They emphasize the importance of a proper selection of patients as well as the requirement for highly qualified physicians to provide the treatment. Another problem associated with the safety of SIT is the potential enhancement of the synthesis of immune complexes after the treatment. SIT causes a decrease in allergen-specific IgE which is slower in circulating immune complexes than in the serum. No data are available to show that SIT induces immune-complex diseases, in either the immunologic or the clinical sense. As far as anaphylactic reactions are concerned, new alternative methods different from the conventional parenteral mode of delivery seem to be safe. Our increased understanding of the altered functions of the immune system justifies the assumption that the more specific the method of SIT administration, the more effective and safe it is.

Allergens↗
PubMed1998

[Mechanism of action for corticosteroids].

The article is the review of the literature data concerning the molecular mechanism of action of corticosteroids in bronchial asthma and related diseases. Extensive research has led to the detailed understanding of the mechanisms underlying the cellular actions of steroids, their interactions with beta 2-agonists and reasons of steroid resistance.

Adrenergic beta-Agonists↗
PubMed1998

[Theophylline in treatment of bronchial obstructive diseases].

The article is the review of the data from literature concerning the new role of theophilline in the management of asthma and chronic bronchoobturative pulmonary disease. Theophilline has been widely used to treat asthma and COPD patients worldwide and is classified as a bronchodilatator, although there is increasing evidence that it has antiinflammatory activity and enhances immunomodulatory effects. The latter is therapeutically relevant to markedly lower serum concentration (even < 10 micrograms/ml) than this required for bronchodilatation. That is particularly clinically important because significant adverse effects have been seen only in the case of doses greater than 10 micrograms/ml.

Adjuvants, Immunologic↗
PubMed1998

[The role of imperfect fungi in etiopathogenesis of allergic rhinitis].

In this paper the role of imperfect fungi in etiopathogenesis of perennial rhinitis was examined. In a group of 26 patients the concentration of total IgE and IgE specific of Candida albicans, Aspergillus fumigatus, Alternaria alternata, Mucor racemosus and Cladosporum herbarum was signified. Oversensibility to imperfect fungi was confirmed in 30.8% of patients: to Candida albicans in 3.8%, to Aspergillus fumigatus in 11.5%, to Alternaria alternata in 3.8%, to Mucor racemosus in 7.6% and to Cladosporum herbarum in 3.8%.

Alternaria↗