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Biomedical subjects

B Romański

Publications and source records attributed to B Romański.

At least 19 recordsLinked to original sources
PubMed1992

[Studies on the possibility of desensitizing patients sensitive to plant pollens and house dust by an oral route].

Oral hyposensitization was carried out in 26 patients with pollinosis and in 67 patients sensitive to house dust with all year symptoms of allergic disease of the skin, airways or conjunctivitis. The patients were hyposensitized with grass pollen extracts and house dust produced by Lab. Sevac. The pollen allergen was administered before the pollinating season, in increasing doses during 18 weeks. The following concentrations were used: 0.1 PNU, 1.0 PNU, 10 PNU, 100 PNU, and 1000 PNU. The house dust allergen was administered in the same manner, using the same concentrations and time during autumn and winter. In the group of patients with plant pollinosis 10 out of 26 did not experience any symptoms of the disease after hyposensitization. In 9 further patients the symptoms were milder. In the group of 44 patients with atopic dermatitis sensitive to house dust, a complete cure was seen in 62% of the patients. In further 25% milder symptoms were observed. In the group of 11 patients allergic to house dust and with the asthma-prurigo syndrome, the respiratory and dermatologic symptoms resolved completely or diminished in 3 and 6 patients respectively. In the group of 7 patients with dermatitis and full year rhinitis, complete resolvement of symptoms was seen in 2 patients and diminished symptoms in 3 cases. In the group of 4 patients with conjunctivitis full resolvement of symptoms was observed in 3, while partial in 1. Only in 3 out of 93 treated subjects intolerance of this therapy was found.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Therapeutic effectiveness of lidocaine in patients with ventricular arrhythmias estimated relative to measurements of drug concentration in serum].

Therapeutic effectiveness of lidocaine intravenous infusions preceded by an initial intravenous dose was studied in 29 patients with ventricular arrhythmias in a course of ischemic heart disease admitted to CCU. Clinical effects were evaluated in correlation with obtained lidocaine concentrations and basic pharmacokinetic parameters. Regression of cardiac arrhythmias was stated in 23 patients (79.3%), inclusive of all acute MI cases. Partial therapeutic effect was observed in 4 patients (13.8%) and no effect in 2 (6.9%). In 12 patients (52.2%) with stated regression of ventricular arrhythmias the full therapeutic effect was observed after initial dose administration. Serum drug concentrations were above the lower limit of the therapeutic range in all cases. Side effects were observed in 3 cases with high serum lidocaine levels caused by impaired drug metabolism or elimination due to the patient's clinical state. Correlation between the infusion rate and obtained stationary condition of drug concentration within therapeutic range seemed to be highly effective in management of ventricular premature beats caused by acute myocardial ischemia but less effective in cases of ischemic and postinfarction cardiomyopathy with heart failure.

Aged↗