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Biomedical subjects

B Roquefeuil

Publications and source records attributed to B Roquefeuil.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Pulse oximetry and thoracopulmonary surgery].

Arterial blood gases are invasive and they provide intermittent information only. On the other hand, pulse oximetry is non invasive, providing continuous monitoring of SaO2 (SpO2). A study was therefore carried out in twelve patients undergoing lung and intrathoracic surgery to determine whether pulse oximetry was a reliable method of monitoring. The SpO2 values obtained using a Physiocontrol Oximeter (Lifestat 1600) were compared with those given by blood gas measurements (SaO2). When ventilation was switched to one-lung ventilation, PaO2 fell in all cases, whatever the method of monitoring, with PaCO2 remaining constant. 46 paired values of SaO2 were compared using linear regression analysis. Correlation between the two methods was good (r = 0.95; p less than 0.001). Pulse oximetry would therefore seem to provide a reliable method of continuous noninvasive and accurate monitoring of oxygenation during lung surgery.

Adult↗
PubMed1988

[Evaluation of the efficacy and tolerance of flumazenil in antagonism of the effects of flunitrazepam on the central nervous system].

The efficacy and tolerance of flumazenil were assessed in a double-blind randomized multicentre trial on 120 ASA I or II patients aged 40.3 +/- 13.9 years. They were anaesthetized with flunitrazepam (25.1 +/- 10.5 micrograms.kg-1.h-1), fentanyl (4.4 +/- 1.9 micrograms.kg-1.h-1) and either vecuronium or pancuronium; residual neuromuscular blockade was antagonized at the end of surgery. 61 patients received flumazenil and 59 a placebo. Sedation comprehension and temporo-spatial orientation were scored at 0, 5, 15, 30, 60, 120 and 240 min after the administration of flumazenil or placebo. Local and general tolerances were evaluated 1 h and 24 h after administration. At the 24th h, the observer's assessment of consciousness, pain, respiration, coughing and vomiting were noted, as well as his identification, or not, of flumazenil or the placebo and their efficacy. Both groups were statistically homogeneous and comparable. Significant and marked efficacy was noted between the 5th and 30th min. There was no difference, at 24 h, between the flumazenil and placebo groups. In most cases, flumazenil was identified by the observer and its efficacy felt to be excellent. No major untoward effect of flumazenil was noted; however a mild and short lasting anxiety occurred in three patients. Tolerance was deemed to be excellent.

Adolescent↗
PubMed1988

Effect of preoperative renin-angiotensin system blockade on hypertension following coronary surgery.

Renin-angiotensin system activation is suspected of being involved in postcoronary surgery hypertension, but appears to be useful in maintaining blood pressure during anesthesia and cardiopulmonary bypass. To clarify these points, 19 patients were compared: ten as a control group and nine who received captopril during two days before surgery. Anesthesia was the same for the two groups, and cardiopulmonary bypass ensured nonpulsatile flow rates. Anesthesia induced a slight decrease in the mean arterial blood pressure of the treated group (91.1 +/- 3.3 mm Hg to 83.3 +/- 3.9 mm Hg), which did not occur in the control group (89.9 +/- 5.8 mm Hg to 89.7 +/- 4.9 mm Hg). During cardiopulmonary bypass, the mean arterial blood pressure was maintained at comparable levels in the two groups (65.6 +/- 3.5 mm Hg in the control group, 72.6 +/- 3.0 mm Hg in the treated group), with same pump flow rates. After cardiopulmonary bypass, the mean arterial blood pressure returned nearly to prebypass values. Postoperatively, three patients in the control group and four in the treated group developed hypertension. Thus, preoperative renin-angiotensin system blockade by a converting-enzyme inhibitor did not impair blood pressure regulation during anesthesia and cardiopulmonary bypass, but failed to prevent hypertension following coronary surgery.

Captopril↗
PubMed1984

Intraventricular administration of morphine in patients with neoplastic intractable pain.

Since February 1981, eight patients with neoplastic intractable pain have been treated by intracerebroventricular administration of small doses of morphine. Morphine was injected into the cerebrospinal fluid through a ventricular reservoir either by direct puncture or by self-administration. Clinical results were very good, and there were no deleterious effects.

Adult↗