Gastroenteritis due to Salmonella subgenus 3 (Arizona). A second case diagnosed in Britain.
The second patient with Arizona gastroenteritis to be diagnosed in Britain had just returned from the United States, where his illness began.
Biomedical subjects
Publications and source records attributed to B Rowe.
The second patient with Arizona gastroenteritis to be diagnosed in Britain had just returned from the United States, where his illness began.
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An outbreak of gastroenteritis due to Salmonella virchow occurred in a maternity hospital in the Midlands in October-November 1968. Twenty-six babies and six mothers were infected. Fifteen of the babies had diarrhoea and 10 of these were in the special care baby unit The only fatal case was that of an infant with gross congenital malformations.The outbreak followed the admission of a patient to the delivery suite who was subsequently shown to be a symptomless excreter of S. virchow. A major factor in the spread of this organism is thought to have been heavy environmental contamination resulting from diarrhoea due to infection of her newborn baby.
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Escherichia coli accounted for 861 (23.9%) of 3,605 episodes of bacteremia in an 18-year prospective survey at St. Thomas' Hospital, a proportion that changed little during the survey. The most common focus of infection leading to nosocomial and community-acquired bacteremia due to E. coli was the urinary tract. Twenty-six percent of adult female patients with E. coli bacteremia resulting from a urinary tract infection were diabetic. The O antigen serotypes identified most often were O6, O2, O1, O4, O15, and O75; the multiply resistant O15 serotype of E. coli was implicated in a community outbreak of urinary tract infection. Ampicillin resistance in strains causing community-acquired infection increased to the same level as that of strains causing nosocomial infection (almost 50%). The overall mortality was 20.7% and was greater in the presence of shock (52.4% vs. 15.3%). Death due to infection occurred in 2.6% and 10.3%, respectively, of cases with urinary tract and non-urinary tract foci. The adverse influence of inappropriate initial therapy on outcome was more marked in the latter half of the study.
A survey was carried out to determine the prevalence of known diabetes amongst West Indians living in Wolverhampton. Two hundred and fifty-one West Indians with diabetes were identified from a computerized register, which records all diabetic patients in the Wolverhampton area attending either the hospital diabetic clinic or general practitioner mini-clinics, and from questionnaire data obtained through local general practitioners. An estimated 4.4% of the Wolverhampton population are of West Indian origin determined by the 1981 census, giving a prevalence of known diabetes of 2.2% compared with 1.2% in the indigenous UK white Caucasian population. Only 4% of these patients were truly insulin-dependent but 38% were insulin-treated, 43% were on oral hypoglycaemic agents and 19% on diet alone. Only 1.6% were diagnosed below the age of 20 years, with peak frequency of diabetes occurring in the age group 45-64 years. Thirty-eight percent of all patients were obese, 40% were hypertensive, but only 4% had a history of angina or myocardial infarction. In UK West Indians non-insulin-dependent diabetes is common and is predominantly a disease of middle age, whereas insulin-dependent diabetes is relatively uncommon.
The objective of the present document is to review the impact of new information on the recommendations made in the last (1999) Canadian Asthma Consensus Guidelines. It includes relevant published studies and observations or comments regarding what are considered to be the main issues in asthma management in children and adults in office, emergency department, hospital and clinical settings. Asthma is still insufficiently controlled in a large number of patients, and practice guidelines need to be integrated better with current care. This report re-emphasises the need for the following: objective measures of airflow obstruction to confirm the diagnosis of asthma suggested by the clinical evaluation; identification of contributing factors; and the establishment of a treatment plan to rapidly obtain and maintain optimal asthma control according to specific criteria. Recent publications support the essential role of asthma education and environmental control in asthma management. They further support the role of inhaled corticosteroids as the mainstay of anti-inflammatory therapy of asthma, and of both long acting beta2-agonists and leukotriene antagonists as effective means to improve asthma control when inhaled corticosteroids are insufficient. New developments, such as combination therapy, and recent major trials, such as the Children's Asthma Management Project (CAMP) study, are discussed.
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Vero cytotoxin-producing Escherichia coli O157 belonging to four phage types (PTs) caused 11 outbreaks of infection in England and Wales in 1995. Outbreak strains of different PTs were distinguishable by DNA-based methods. Pulsed-field gel electrophoresis best discriminated among strains belonging to the same PT, distinguishing six of the seven PT2 outbreak strains and both PT49 outbreak strains.
For epidemiologic investigations, the primary subdivision of Salmonella Typhi is vi-phage typing; 106 Vi-phage types are defined. For multidrug-resistant strains the most common types have been M1 (Pakistan) and E1 (India, Pakistan, Bangladesh, and the Arabian Gulf); a strain untypable with the Vi phages has been responsible for a major epidemic in Tajikistan. Most often, isolates from the Indian subcontinent have been resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides, tetracyclines, and trimethoprim; but in the 1997 Tajikistan outbreak, the epidemic strain was also resistant to ciprofloxacin. For multidrug-resistant strains, subdivision within phage type can be achieved by plasmid profile typing and pulsed-field gel electrophoresis.
In that supplement are given the characters of new Salmonella serotypes recognized in 1974 by WHO International Salmonella Center. Twenty-six belong to the sub-genus I, 20 to the sub-genus II and 8 to the sub-genus III. A new O antigen (67) and a new H antigen phase 1 (Z60) have been approved. Biochemical and antigenic variants of already known serotypes are described.
Between 13 and 16 September 1985, 168 of 419 Filipino workers, living in a camp near Dammam, Saudi Arabia, developed acute gastroenteritis with diarrhoea, vomiting, abdominal pain, and low-grade fever. The outbreak was confined to those who ate from a single kitchen. The median approximate incubation period of the disease was 34 hours (range 8 to 96 hours). Salmonella minnesota was isolated from the stools and rectal swabs of 34% of the patients. One of the 27 cooks was positive for the organism. There was no infection diagnosed among 390 close contacts of the patients, and the organism was also not grown from samples of leftover or fresh food. All isolates were sensitive to most of the commonly used antimicrobials, except tetracycline and streptomycin. A particular meal served from a single kitchen was tentatively implicated as the source of the outbreak.
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In this supplement are given the characters of 40 new Salmonella serotypes recognized in 1978 by WHO collaborating Centre for reference and research on Salmonella: 29 belong to the sub-genus I, 3 to the sub-genus II and 8 to the sub-genus III. Biochemical and antigenic variants of already known serotypes are described. A new H factor (Z63) is recognized.
Strains of S. typhimurium biotype 6 possess neither tetrathionate reductase nor arginine dihydrolase; they use trehalose, but not inositol and glycerol. Most are multi-resistant to antibiotics and are responsible for numerous outbreaks of salmonellosis. They have been divided into four groups. Groups I includes strains of phage type 207, and was predominant in Belgium from 1969 to 1976. Group II includes strains of a classical variety belonging to phage types 49, 193 and 204. Group III includes strains of the copenhagen variety belonging to the same phage types. Strains of groups II and III are generally resistant to trimethoprim. They have predominated in Belgium since 1978 (mainly phage type 193). Group IV contains a few strains of various phage types, generally non-resistant, which have caused no epidemics.