PubMed Health⌕ Search

Biomedical subjects

B Rutkowski

Publications and source records attributed to B Rutkowski.

At least 109 records · Page 6Linked to original sources
PubMed1994

[P1 blood group, secretion status and susceptibility to asymptomatic bacteriuria in diabetes].

Blood-group antigens found on uroepithelial cells and in the secretions may affect bacterial adherence and thereby the predisposition to urinary tract infection. We determined P1, Lewis-blood-group phenotype and secretor status in patients with diabetes mellitus: 12 with asymptomatic bacteriuria and 7 without its presence. There was no difference between the two groups in the distribution of the P1 phenotype. There was also no statistical difference in the distribution of the Lewis phenotype and secretor status, although there appeared to be general trend of higher number of Le (a+b-) phenotype and non-secretors present in the asymptomatic bacteriuria group. Further studies are necessary to determine the role of blood groups and secretor status in the pathogenesis and susceptibility to urinary tract infection.

Adult↗
PubMed1994

[Dynamics of changes in lipid metabolism during the first year after kidney transplantation].

Dyslipidemia is one of the first metabolic dysfunction observed among patients with end stage renal disease. It can also induce acceleration of renal tissue damage. Kidney transplantation may cause recovery of some dysfunction in lipid metabolism while influencing deterioration of others. The aim of this study was to monitor dynamics of basic lipid parameters in the first year after kidney transplantation. The sample included 25 patients (9W, 16M), aged 18-59, avg. 36. We have measured concentration of the following parameters in blood serum: triglycerides (TG), total cholesterol (CH-C) and apolipoprotein B (Apo B). Simultaneously, functions of transplanted kidney were tested with use of routine methods. The immunosuppressive treatment of patients followed the scheme: cyclosporine + prednisolone + azathioprine. The treatment influence on lipid disorders was measured by relevant correlation coefficients. The obtained results point to the observation that in the first year after kidney transplantation the TG concentration gradually decreases, with simultaneous continuous increase of CH-C concentration, mainly due to LDL concentration increase. No influence of immunosuppressive treatment on lipid parameters was observed. However, lipid dysfunction, especially TG, correlated with kidney function.

Adolescent↗
PubMed1994

[Development of dialysis therapy in Poland during the decade 1984-1993].

Data concerning status of dialysis therapy in Poland during decade 1984-1993 were analysed. It was found that: 1. number of dialysis units increased two times (54-105), 2. number of dialysis stations raised 2.5 times (294-812), 3. number of patients treated with maintenance dialysis was increased 3.5 times (962-3783). These data showed dynamic development of this method of renal replacement therapy in Poland. However, in Poland acceptance rate dto dialysis therapy is still not satisfactory (30-35%). The Programme of the Country Committee for the Promotion of Nephrology based on the central founding system for the renal replacement therapy provides that by the end of 1995 it will be possible to treat 50% of patients with chronic uraemia. Continuous development of different methods of renal replacement therapy (hemodialysis, continuous ambulatory peritoneal dialysis, renal transplantation) is necessary for achieving possibilities compared with developed countries.

Health Promotion↗
PubMed1994

[Acquired cysts of the kidney in patients treated with long-term dialysis].

There are many reports about development of AC in patients on dialysis therapy (DT) and about their pathophysiological consequences. The aim of our studies was to determine the prevalence of AC in patients treated with hemodialysis in dialysis centre in Gdańsk. We also tried to asses relationship between the presence of AC, age and sex of the patients, the duration of DT and level of haemoglobin (Hb), hematocrit (Ht), red blood cells (RBC) and the prevalence of hypertension (H). Renal ultrasound scan was performed in 54 patients, among them 26 (48.5%) had acquired cysts. No correlation was found between presence of cysts and age, sex and nature of the underlying renal disease. There was a positive correlation between the prevalence of AC and the duration of DT (DT < 1 year--36.8/, DT < 3 years--42.8%, DT > 3 years--59%), it did not, however, reach statistical significance. Haematological parameters did not differ significantly between both groups, AC--patients, however, received more blood transfusions (2983 ml/year vs. 2485 ml/year). Similarly, there were no differences in systolic and diastolic blood pressures (mean yearly values before and after HD) between both groups, but in AC+ group more patients needed intensive treatment with hypotensive drugs. Our results indicate that the prevalence of AC increases with the duration of DT. The possibility that the presence of AC may influence severity of anaemia and hypertension is suggested.

Adolescent↗
PubMed1994

[Tuberculosis--an increasing risk for patients treated with long-term hemodialysis].

UNLABELLED: In the recent years an increase in the incidence of tuberculosis (TB) has been observed world-wide, including Poland. In the Department of Nephrology of Gdańsk School of Medicine, an increase in the incidence of TB has been observed among patients undergoing maintenance hemodialysis (HD). The aim of this work was to analyse the natural history of TB infection in this group of patients. Over the last seven years TB was diagnosed in 9 patients (5 female, 4 male) out of 171 patients on HD (5.2%). Seven of those were diagnosed in the last three years. The average age of patients with TB was 47.2 years. In three patients the clinical symptoms of TB has appeared during the first year of hemodialysis treatment (average 5.6 months), in the rest the mean period of dialysis before the TB diagnosis was 60 months. The TB was extrapulmonary (lymph nodes, pericardium and bones) in 5 patients. In most cases the clinical symptoms of TB were present, however, one patient was asymptomatic. Four cases were confirmed microbiologically and/or histopathologically. All patients treated with antituberculous drugs showed clinical recovery or cure, however in six patients the anti TB treatment was complicated by adverse drug reactions. One patient died and TB was diagnosed post mortem. In two patients who had had lymph nodal TB 2 and 6 years earlier, we now observed pulmonary TB. There were no cases of TB among hemodialysis unit staff. CONCLUSIONS: There is a increasing incidence of TB in population of HD patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1994

[The role of the adrenergic nervous system in control of extrarenal potassium disposal in acute renal failure--unclear pathophysiological and clinical problem].

The effect of catecholamines on the regulation of extra-renal potassium homeostasis is well known in some pathological conditions such eg. chronic renal failure. However, the role of catecholamines on potassium homeostasis in acute renal failure has not been established yet. There are only scarce amount literature on this issue showing that both clinical and experimental acute renal failure plasma catecholamines are elevated. Presumably, acute renal failure associated hyperkalemia is ameliorated by raised plasma catecholamine concentration.

Acute Kidney Injury↗
PubMed1994

[Bone tuberculosis in a hemodialyzed patient--a difficult diagnostic problem].

Recent observations indicate quite high incidence of tuberculosis (tbc) in haemodialysis population. But there are really only few reports of arthritis the infection. Mycobacterial process in this location may imitate many other pathological states. Our report refers to 45-year-old man with right knee the infection and the peri-arthritic tissue, which developed after 8 years of renal replacement treatment. No evidence of the was noted before. Chronic pain, swelling and instability of the knee led finally to surgical extraction of diagnostic material, which contributed to final diagnosis. We consider this report to be important because of only few reported cases of the arthritis. Additionally unnecessary delay in commencement of treatment may lead to bone destruction.

Humans↗
PubMed1994

Effect of epinephrine infusion on plasma potassium and its urinary excretion in rats subjected to subtotal nephrectomy.

Extrarenal potassium handling plays pivotal role in potassium homeostasis and is regulated by several hormones including epinephrine. The aim of this study was to look how epinephrine affects both extrarenal and renal potassium handling in rats with chronic renal failure. In subtotally nephrectomized rats, epinephrine (0.05 micrograms/kg per h) plus KCl (0.5 mmol/kg per h) were infused i.v. Plasma potassium and its fractional urinary excretion were measured simultaneously in five clearance periods. Each clearance period lasted 20 min and glomerular filtration rate was estimated as inulin clearance. Regardless of epinephrine infusion plasma potassium as well as fractional potassium excretion were higher in rats with chronic renal failure than in controls (shame--operated). It was concluded that the effect of epinephrine on both extrarenal and renal potassium handling was ameliorated in rats with chronic renal failure.

Animals↗
PubMed1994

Importance of iron status monitoring during erythropoietin treatment in uremic predialysis patients.

Since recombinant human erythropoietin (r-Hu EPO) has been introduced to the treatment of anemia in uremic patients the issue of optimal therapy appeared. For proper erythropoiesis not only erythropoietin but also iron, folic acid and B12 vitamin are needed. Iron deficiency is one of the most common factors causing resistance to r-Hu EPO in uremic patients, so its recognition and eventual supplementation is required for optimal hemopoietic response. The aim of presented study, besides monitoring hematological changes, was to measure iron status parameters such as iron, transferrin, ferritin and percentage of hypochromic erythrocytes and estimation of their usefulness in monitoring iron deficiency during r-Hu EPO treatment.

Adult↗
PubMed1991

A model for the role of HLA-DQ molecules in the pathogenesis of juvenile chronic arthritis.

Restriction fragment length polymorphism (RFLP) typing of MHC-class II loci DRB, DQA1, DQB1, DQA2 and DPB1 was performed in 94 patients with seronegative juvenile chronic arthritis (JCA) and 184 random controls. Analysis of allele frequencies and MHC-class II 4-loci haplotypes indicate: (1) Susceptibility to JCA is more strongly associated with the HLA-DQ subregion than with the HLA-DR subregion, especially in early onset pauciarticular JCA (EOPA-JCA). (2) Haplotype and sequence analysis show two independent MHC-class II associations for susceptibility to EOPA-JCA, one located in DQA1, the other in DPB1. (3) Two RFLP defined patterns of the DQA1 locus, DQA1.5 (DQA1*0501) and DQA1.8 (DQA1*0401, *0601) are strongly associated with the disease. (4) Analysis of amino-acid (AA) sequences coded in exon 2 of DQA1 reveals an AA sequence of six AAs common to all three associated DQA1 alleles. This suggests a model that includes a functional role for HLA-DQ molecules in the pathogenesis of JCA.

Alleles↗
PubMed1991

[Subcutaneous administration of recombinant human erythropoietin (R-EPO) in the treatment of anemia in predialysis patients with chronic renal failure].

10 anemic (HB less than 9.0 g/dl) predialysis patients with chronic renal failure were treated for three months with s.c. administration of r-Epo. Blood morphological parameters were estimated using hematological autoanalyser Technicon H1. An increase of the mean hemoglobin (Hb) level from 8.39 to 10.57 g/dl was observed. In 8 patients Hb concentration after 3 months therapy ranged from 9.4 to 12.7 g/dl, but in the remaining two of them Hb was lower than 9.0 g/dl. Appearance of a high percentage of hypochromic erythrocytes is probably the most characteristic response to r-Epo treatment. This phenomenon was caused by iron deficiency. A significant increase of serum creatinine and BUN levels were observed in treated patients, without the concomitant decrease of endogenous creatinine clearance. No clinical symptoms suggesting deterioration of the renal function were observed. Subcutaneous therapy with r-Epo appeared an effective and convenient method of treatment of anemia in predialysis patients.

Adult↗
PubMed1991

[Evaluation of erythropoiesis under the influence of recombinant human erythropoietin (R-EPO) in dialyzed patients].

5 deeply anemic (Hb less than 8 g/dl, Ht less than 25%) dialyzed patients with chronic renal failure were treated during four months with r-Epo. Blood cells morphological parameters were estimated using hematological autoanalyser Technicon H1. Satisfactory increase of the Hb levels and RBC counts were observed in 4 patients, in one the improvement was insignificant. We observed three types of response to r-Epo treatment: 1) macrocytic type, 2) hypochromic type, and 3) non-hypochromic type, without lasting macrocytosis. Our results suggest that type of erythropoiesis depends on other active biological substances (iron, folic acid, vit. B12) necessary for correcting erythropoiesis. r-Epo administration appeared to be a safe and effective method of anaemia treatment in dialyzed patients. Its administration eliminated blood transfusion for six months.

Adult↗
PubMed1990

Renal actions of atriopeptin III in genetic and renovascular models of hypertension in the rat.

The renal actions of atriopeptin III were compared in sham control, spontaneous and Goldblatt (2-K 1-C) hypertensive rats. Atriopeptin III, administered at 125. 250 and 500 ng/kg or 1.0, 1.5 and 2.0 micrograms/kg, into sham control rats had no effect on blood pressure or renal haemodynamics but caused dose related increases in urine flow, absolute and fractional sodium excretions, from 44 to 248%. Similar excretory responses to this dose range of atriopeptin III were obtained in spontaneously hypertensive rats. Atriopeptin III given at 125, 250 and 500 ng/kg into 2-K 1-C Goldblatt hypertensive rats increased reversibly left kidney urine flow, absolute and fractional sodium excretion by between 55 and 74% which were similar responses to those of sham control left kidneys. By contrast, atriopeptin III had much smaller effects on water and sodium excretions of the right clipped kidneys. These results suggest that atrial natriuretic peptides may be useful in mobilising fluid in genetic hypertension but their usefulness may be restricted in renovascular forms of hypertension.

Animals↗
PubMed1990

The action of atriopeptin III on renal function in two models of chronic renal failure in the rat.

1. The natriuretic and diuretic effects of atriopeptin III (125, 250 and 500 ng kg-1, i.v.) were studied in groups of rats anaesthetized with pentobarbitone which were either sham controls, unilaterally nephrectomized controls, adenine-fed or subtotal nephrectomy chronic renal failure models. 2. Atriopeptin III given at these doses to the sham control animals had no effect on blood pressure, renal blood flow or glomerular filtration rate but reversibly increased urine flow, between 46% to 54%, absolute sodium excretion, between 52% to 61%, and fractional sodium excretion, between 48% to 54% (all P values less than 0.05) from the lowest to the highest dose. The adenine-fed chronic renal failure group of rats had a reduced renal blood flow of between 30 and 75%, and glomerular filtration rate of approximately 20%, compared to the sham controls. Administration of atriopeptin at 125, 250 and 500 ng kg-1 to the animals with renal failure increased water and sodium excretion to the same degree as observed in the sham group of rats. 3. In the group of unilaterally nephrectomized rats, atriopeptin III, at 125, 250 and 500 ng kg-1 increased urine flow by 36%, 47% and 72%, respectively, absolute sodium excretion by 37%, 57% and 106%, respectively, and fractional sodium excretion by 46%, 45% and 102%, respectively. A similar pattern of responses was observed in the subtotal nephrectomy, chronic renal failure group in which filtration rate was approximately 4 times less than the controls. 4. These results show that in two different models of chronic renal failure, atriopeptin III still caused a natriuresis and diuresis. This suggests that the nephrons retain sensitivity to the atrial natriuretic peptides in diseases such as chronic renal failure and that these compounds may be useful in mobilizing body fluids in this situation.

Adenine↗